Results 121 to 130 of about 11,832,408 (324)

Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung

Respiratory Research, 2018
BackgroundAccumulation mode particles (AMP) are formed from engine combustion and make up the inhalable vapour cloud of ambient particulate matter pollution.
A. Fonceca, G. Zosky, E. M. Bozanich, E. Sutanto, A. Kicic, P. McNamara, D. Knight, P. Sly, D. Turner, S. Stick   +9 more
semanticscholar   +1 more source

The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes [PDF]

, 2007
Context: Obesity-associated inflammation is a contributory factor in the pathogenesis of type 2 diabetes mellitus (T2DM); the mechanisms underlying the progression to T2DM are unclear.
Adam R. Baker, Alison L. Harte, Aranda, Asensio, Baan, Banerjee, Bokarewa, Borst, Bradford, Christine M. Kusminski, Creely, Curat, Einstein, Ffolliott M. Fisher, Fu, Graveleau, Hirosumi, Hotamisligil, Kusminski, Lehrke, Li, Lin, McTernan, McTernan, Nancy F. da Silva, Pagano, Patel, Philip G. McTernan, Rae, Rajala, Rajala, Rangwala, Reilly, Ridker, Roeder, Sato, Savage, Shetty, Silswal, Steppan, Steppan, Steven J. Creely, Sudhesh Kumar, Tzou, Weisberg, Xu   +45 more
core   +1 more source

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Peculiarities of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly) polymorphism prevalence in patients with acute brucellosis with cardiovascular lesions

Journal of Education, Health and Sport, 2018
Currently, there are single data on the relationship between TLR-2 polymorphisms (Arg753Gln) and TLR-4 (Asp299Gly) polymorphisms and susceptibility to brucellosis.
Elchin Huseynov Mammad oglu
doaj   +3 more sources

DHA induces apoptosis of human malignant breast cancer tissues by the TLR-4/PPAR-α pathways

Oncology Letters, 2017
Docosahexaenoic acid (DHA) oil is an important polyunsaturated fatty acid for the human body. Evidence has demonstrated that DHA is beneficial for inhibiting mammary carcinogenesis.
Lijing Geng, Wei Zhou, Bing-Fen Liu, Xinyun Wang, Bo Chen   +4 more
semanticscholar   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

TLR-4/Wnt modulation as new therapeutic strategy in the treatment of glioblastomas

OncoTarget, 2018
Purpose Glioblastomas are highly aggressive brain tumors. Various pathways are involved in gliomagenesis, among which the Wingless (Wnt) signaling. Dickkopf protein-related protein 3 (Dkk-3) interacts with proteins of Wnt pathwayas inhibitor.
Giovanna Casili, M. Caffo, M. Campolo, V. Barresi, G. Caruso, S. Cardali, M. Lanza, R. Mallamace, A. Filippone, A. Conti, A. Germanò, S. Cuzzocrea, E. Esposito   +12 more
semanticscholar   +1 more source

Utility of serological markers in inflammatory bowel diseases: Gadget or magic? [PDF]

, 2007
The panel of serologic markers for inflammatory bowel diseases (IBD) is rapidly expanding. Although anti-Saccharomyces cerevisiae antibodies (ASCA) and atypical perinuclear antineutrophil cytoplasmic antibodies (P-ANCA) remain the most widely ...
Altorjay, István, Lakatos, Péter László, Norman, G. L., Papp, Mária   +3 more
core   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources