Results 251 to 260 of about 11,832,408 (324)

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

Modified citrus pectin ameliorates methotrexate-induced hepatic and pulmonary toxicity: role of Nrf2, galectin-3/TLR-4/NF-κB/TNF-α and TGF-β signaling pathways. [PDF]

Front Pharmacol
Ismail R, Habib HA, Anter AF, Amin A, Heeba GH.   +4 more
europepmc   +1 more source

Proteome‐Wide Analysis of Palmitoylated Proteins in Macrophages Reveals Novel Insights Into Early Immune Signaling

PROTEOMICS, EarlyView.
ABSTRACT Protein S‐palmitoylation, a reversible lipid modification, plays critical roles in regulating protein function and localization. However, its comprehensive role in the rapid reprogramming of macrophages during early immune responses remains incompletely understood.
Hyojung Kim, Jiraphorn Issara‐Amphorn, Sung Hwan Yoon, Anirban Banerjee, Aleksandra Nita‐Lazar   +4 more
wiley   +1 more source

Physcion Mitigates LPS-Induced Neuroinflammation, Oxidative Stress, and Memory Impairments via TLR-4/NF-кB Signaling in Adult Mice. [PDF]

Pharmaceuticals (Basel)
Ahmad S, Choe K, Badshah H, Ahmad R, Ali W, Rehman IU, Park TJ, Park JS, Kim MO.   +8 more
europepmc   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Unique pathways downstream of TLR-4 and TLR-7 activation: sex-dependent behavioural, cytokine, and metabolic consequences. [PDF]

Front Cell Neurosci
Dunstan IK, McLeod R, Radford-Smith DE, Xiong W, Pate T, Probert F, Anthony DC.   +6 more
europepmc   +1 more source

Perioperative treatment with the new synthetic TLR‐4 agonist GLA‐SE reduces cancer metastasis without adverse effects

International Journal of Cancer, 2016
P. Matzner, L. Sorski, L. Shaashua, E. Elbaz, H. Lavon, R. Melamed, E. Rosenne, N. Gotlieb, A. Benbenishty, S. Reed, S. Ben-Eliyahu   +10 more
semanticscholar   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Insights into geriatric health: primary sarcopenia and innate immunity dynamics, examining SARC-F, serum TLR 4, TLR 9, and resolvin levels. [PDF]

Intern Emerg Med
Bilgin S, Suzan V, Avci S, Yavuzer H, Bolayirli IM, Doventas A, Erdincler DS.   +6 more
europepmc   +1 more source

Anti-inflammatory effects of Bifidobacterium longum subsp infantis secretions on fetal human enterocytes are mediated by TLR-4 receptors.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2016
Di Meng, Weishu Zhu, K. Ganguli, H. Shi, W. Walker   +4 more
semanticscholar   +1 more source