Results 41 to 50 of about 300,160 (284)
Human Plasmacytoid Dendritic Cells and Cutaneous Melanoma
Cells, 2020 The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Matilde Monti +4 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2021 Outer membrane vesicles (OMV) are exosomes naturally released from the surface of Gram-negative bacteria. Since the ’80s, OMVs have been proposed as powerful vaccine platforms due to their intrinsic self-adjuvanticity and ability to present multiple ...
Omar Rossi +2 more
doaj +1 more source
Dynamical friction and the evolution of satellites in virialized halos: the theory of linear response [PDF]
, 1999 The evolution of a small satellite inside a more massive truncated isothermal spherical halo is studied using both the Theory of Linear Response for dynamical friction and N-Body simulations.
Bontekoe Tj. R. +14 more
core +3 more sources
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Basophil activation through TLR2 and TLR4 signaling pathways
AIMS Allergy and Immunology, 2018 Basophils are effector cells that respond to protease allergens and parasites, thus contributing to allergic inflammation and Th2 differentiation. However, the molecular interactions through which pathogens promote activation as well as recruitment of ...
Manal Alkan +6 more
doaj +1 more source
Human Vaccines & Immunotherapeutics, 2020 Traditional non-living vaccines are often least effective in the populations that need them most, such as neonates and elderly adults. Vaccine adjuvants are one approach to boost the immunogenicity of antigens in populations with reduced immunity ...
Orli Even-Or +3 more
doaj +1 more source
Cells, 2020 Human Toll-like receptor (TLR) signaling plays a vital role in intestinal inflammation by activating the NF-κB pathway. By querying GENT2 datasets, we identified the gene expression level of TLR2 and TLR4 as being substantially increased in ...
Hsiang-Chi Huang +6 more
doaj +1 more source
Биопрепараты: Профилактика, диагностика, лечение, 2021 Kagocel® is used in Russia for the treatment of viral infections. In terms of its chemical structure, Kagocel® active ingredient is a copolymer of gossypol polyphenol and carboxymethylcellulose.
T. M. Sokolova, V. V. Poloskov
doaj +1 more source
Chicken Toll-like Receptor 3 Recognizes Its Cognate Ligand When Ectopically Expressed in Human Cells [PDF]
, 2007 Recognition of pathogens by toll-like receptors (TLRs) causes activation of signaling cascades that trigger cytokine secretion and, ultimately, innate immunity.
Bauer, Stefan +7 more
core +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source