Results 51 to 60 of about 138,799 (244)

A KIR-TLR connection

Blood, 2010
Killer immunoglobulin-like receptors (KIRs) are well-known for binding human leukocyte antigen (HLA) and allowing natural killer (NK) cells to monitor HLA levels on host cells. Unexpectedly, Sivori and colleagues have found that certain KIRs can also bind microbial nucleic acid and deliver it ...
openaire   +3 more sources

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

RNF213 Is an Interferon‐Stimulated Gene That Targets Influenza A Virus NP and Activates MDA5 to Restrict Infection

Advanced Science, EarlyView.
RNF213 is characterized as a dual‐functional antiviral effector. It directly mediates the degradation of the influenza A virus nucleoprotein (NP) while simultaneously activating the MDA5‐mediated innate immune signaling pathway. This coordinated response establishes a powerful host defense system against viral infection. ABSTRACT Influenza A virus (IAV)
Haoning Li, Yuying Zhang, Jingjing Wang, Qianqian Zhang, Hailiang Sun, Fanhua Wei   +5 more
wiley   +1 more source

Association between polymorphisms of IL33 and IL37 and atopic dermatitis

Медицинская иммунология
Atopic dermatitis (AD) is a chronic recurrent inflammatory disease accompanied by severe itching. One of the leading mechanisms underlying the development of AD is an imbalance of the Th1/Th2 cells immune response, which leads to an increased production ...
O. A. Svitich, O. Yu. Olisova, M. B. Potapova, E. A. Meremianina, N. D. Rasskazova, E. A. Belokopytova, A. A. Solodkova, A. A. Murzina, I. B. Semenova, A. G. Upatova   +9 more
doaj   +1 more source

Effects of Separate and Concomitant TLR-2 and TLR-4 Activation in Peripheral Blood Mononuclear Cells of Newborn and Adult Horses. [PDF]

PLoS ONE, 2013
Deficient innate and adaptive immune responses cause newborn mammals to be more susceptible to bacterial infections than adult individuals. Toll-like receptors (TLRs) are known to play a pivotal role in bacterial recognition and subsequent immune ...
Johannes Cornelis Vendrig, Luc Edgar Coffeng, Johanna Fink-Gremmels   +2 more
doaj   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Effect of the organoselenium compound 974zh on the TLR2 and TLR4 gene expression in blood and spleen cells of experimental animals when co-administered with Yersinia pestis EV

Acta Biomedica Scientifica
One of the important directions for increasing the immunogenic properties of vaccine strains against highly dangerous infections is the search for adjuvants that not only stimulate the immunological effectiveness of vaccination, but can also provide a ...
A. B. Pyatidesyatnikova, V. I. Dubrovina, O. V. Yurieva, K. M. Korytov, T. I. Ivanova, V. A. Potapov, M. V. Musalov, S. V. Balakhonov   +7 more
doaj   +1 more source

Çeşitli Hastalıklarda Toll Benzeri Reseptörlerin Rolü

Sakarya Tıp Dergisi, 2012
Toll benzeri reseptörler, patojenlerin tanınmasından sorumlu doğal immün reseptörlerdir. İnsanlarda on farklı toll benzeri reseptör tanımlanmıştır. Toll benzeri reseptörler çeşitli hastalıklarda ekzojen ligandlar (bakteriyel, viral ve fungal patojenler ...
Berrak Güven, Murat Can
doaj   +1 more source

A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors. [PDF]

PLoS ONE, 2013
Toll-like Receptors (TLR) are phylogenetically conserved transmembrane proteins responsible for detection of pathogens and activation of immune responses in diverse animal species.
Marylene Y Peroval, Amy C Boyd, John R Young, Adrian L Smith   +3 more
doaj   +1 more source

CD44 Suppresses TLR-Mediated Inflammation [PDF]

The Journal of Immunology, 2008
Abstract The cell adhesion molecule CD44, which is the major hyaluronan receptor, has been implicated in the binding, endocytosis, and metabolism of hyaluronan. Previous studies have revealed that CD44 plays crucial roles in a variety of inflammatory diseases.
Hidetada, Kawana, Hirokazu, Karaki, Morihiro, Higashi, Masaru, Miyazaki, Frank, Hilberg, Motoo, Kitagawa, Kenichi, Harigaya   +6 more
openaire   +2 more sources