Results 271 to 275 of about 101,572 (275)

TLR2 Arg677Trp polymorphism in leprosy: revisited

Human Genetics, 2005
We investigated the Toll-like receptor 2 (TLR2) Arg677Trp polymorphism, associated with lepromatous leprosy in the Korean population and shown to abrogate TLR2-mediated signalling in response to mycobacterial ligands, in 286 Indian leprosy patients and 183 ethnically matched controls.
Dheeraj Malhotra, Vineet Relhan, Belum Siva Nagi Reddy, Ramesh Bamezai   +3 more
openaire   +3 more sources

β3 Integrin as a Coreceptor for TLR2

Science Signaling, 2008
Toll-like receptor 2 (TLR2) is one of a family of TLRs involved in recognition of pathogenic molecular motifs. TLR2 signaling is specifically activated by bacterial lipoproteins, such as LTA (lipoteichoic acid) and zymosan, and can be activated by synthetic bacterial lipopeptides (BLPs) consisting of tri- or di-palmitoyl- S
openaire   +2 more sources

Fungal Recognition by TLR2 and Dectin-1

2008
The innate immune system utilizes multiple receptors to recognize fungal pathogens, and the net inflammatory response is controlled by interactions between these receptors. Many fungi are recognized, at least in part, by Toll-like receptor 2 (TLR2) and Dectin-1.
David M. Underhill, Helen S. Goodridge
openaire   +3 more sources

Does TLR2 regulate intestinal inflammation?

European Journal of Immunology, 2010
AbstractThere is almost no aspect of the immune response that is not regulated by TLR. Initially described as drivers of the innate immune response to pathogens, it is now clear that the TLR family can also influence most aspects of adaptive immunity, as well as determine how tissue cells interact with microbes in their environment.
openaire   +3 more sources

Current Perspectives of TLR2 Signalling in the Retina

Toll-like receptor 2 (TLR2) signalling is crucial in initiating the innate immune response. Under normal conditions, TLR2 can recognise and respond to danger signals in the body and protect against damaging pathogens and molecules. However, dysregulation of this tightly controlled cascade has been implicated in various retinal disorders. There are many
Rachel, Dalton, Sarah, Doyle
openaire   +2 more sources