Results 91 to 100 of about 63,490 (224)

The ectodomain of TLR3 receptor is required for its plasma membrane translocation. [PDF]

PLoS ONE, 2014
Toll-like receptor 3 (TLR3) is a dsRNA sensing receptor that is localized in the cellular compartments but also at the plasma membrane. Overexpression of UNC93B1 promoted localization of TLR3, but not other nucleic acid sensing TLRs, to the plasma ...
Jelka Pohar, Nina Pirher, Mojca Benčina, Mateja Manček-Keber, Roman Jerala   +4 more
doaj   +1 more source

Dual effect of Thymosin α 1 on human monocyte-derived dendritic cellin vitrostimulated with viral and bacterial toll-like receptor agonists [PDF]

, 2015
OBJECTIVES: Thymosin α 1 (Tα1) recently gained interest as immune adjuvant for vaccines because of its ability to modulate the T-cell/dendritic cell (DC) axis and to improve antibody production.
Coccia, Eliana Marina, Cruciani, Melania, Etna, Marilena Paola, Garaci, Enrico, Giacomini, Elena, Pardini, Manuela, Rizzo, Fabiana, SCAGNOLARI, CAROLINA, Severa, Martina   +8 more
core   +1 more source

Small-Molecule Inhibitors of the TLR3/dsRNA Complex [PDF]

Journal of the American Chemical Society, 2011
The protein-RNA interface has been regarded as "undruggable" despite its importance in many biological processes. The toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex provides an exciting target for a number of infectious diseases and cancers.
Kui, Cheng, Xiaohui, Wang, Hang, Yin
openaire   +2 more sources

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Differences in gene regulation by TLR3 and IPS-1 signaling in murine corneal epithelial cells

Scientific Reports, 2023
Toll-like receptor 3 (TLR3) and interferon-beta promoter stimulator-1 (IPS-1) are associated with antiviral responses to double-stranded RNA viruses and contribute to innate immunity.
Seitaro Komai, Mayumi Ueta, Hiromi Nishigaki, Katsura Mizushima, Yuji Naito, Shigeru Kinoshita, Chie Sotozono   +6 more
doaj   +1 more source

Drift, not selection, shapes toll-like receptor variation among oceanic island populations [PDF]

, 2015
Understanding the relative role of different evolutionary forces in shaping the level and distribution of functional genetic diversity among natural populations is a key issue in evolutionary and conservation biology.
Acevedo-Whitehouse, Aguilar, Akira, Alcaide, Areal, Basu, Belvin, Betrán, Bollmer, Cabe, Chen, Cramp, Downing, Ekblom, England, Excoffier, Fornůsková, Frankham, Frankham, Garza, Gautschi, Girard, Goslee, Grueber, Grueber, Grueber, Grueber, Hall, Hartl, Hartmann, Hedrick, Hudson, Hughes, Illera, Jensen, Jiggins, Kalinowski, Keestra, Klein, Kryazhimskiy, Librado, Manly, Mikami, Miller, Misch, Murrell, Murrell, Nakajima, Ohta, Oliver, Outlaw, Piertney, Poltorak, Pond, Pond, Quéméré, R Development Core Team, Raymond, Richardson, Roach, Schröder, Sommer, Spurgin, Spurgin, Spurgin, Spurgin, Stephens, Sutton, Takeuchi, Tamura, Teacher, Trowsdale, Tschirren, Tschirren, Turner, Voelker, Winternitz, Wlasiuk, Yoneyama   +78 more
core   +2 more sources

Are we hallucinating or can psychedelic drugs modulate the immune system to control inflammation?

British Journal of Pharmacology, EarlyView.
Psychedelic drugs that activate 5‐HT2A receptors have been long used for cultural, medicinal and recreational purposes. Interest in psychedelics for treating psychiatric disorders has resurged recently and is well documented; less well recognised are their anti‐inflammatory properties. Growing evidence now demonstrates that psychedelics modulate immune
Omar Qureshi, Jamie Cowley, Ashley Pegg, Alison J. Cooper, John Gordon, Catherine A. Brady, Antonio Belli, Sam Butterworth, Rachel Upthegrove, Nick Andrews, Nicholas M. Barnes   +10 more
wiley   +1 more source

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells [PDF]

, 2012
In the course of primary infection with herpes simplex virus 1 (HSV-1), children with inborn errors of TLR3 immunity are prone to HSV-1 encephalitis (HSE) 1–3.
Abel, Laurent, Abhyankar, Avinash, Al-Muhsen, Saleh, Casanova, Jean-Laurent, Ciancanelli, Michael J., Daley, George Quentin, Elkabetz, Yechiel, Goldstein, Peter A., Herman, Melina, Jouanguy, Emmanuelle, Keros, Sotirios, Lafaille, Fabien G, Mostoslavsky, Gustavo, Notarangelo, Luigi D., Ordovas-Montanes, Jose Manuel, Pessach, Itai M., Plancoulaine, Sabine, Schlaeger, Thorsten M., Studer, Lorenz, Tardieu, Marc, Tu, Edmund, Ying, Shui-Wang, Zhang, Shen-Ying   +22 more
core   +1 more source

MDA5 complements TLR3 in suppression of neuroblastoma

Oncotarget, 2015
Toll-like receptor3 (TLR3) has been confirmed to be differentially expressed in neuroblastoma (NB), and predicts a favorable prognosis with a high expression in tumor tissues. Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral ...
Wen-Ming, Hsu, Chao-Cheng, Huang, Hsin-Yu, Lee, Pei-Yi, Wu, Min-Tsui, Wu, Hui-Ching, Chuang, Li-Ling, Lin, Jiin-Haur, Chuang   +7 more
openaire   +3 more sources

Fatal spinal cord compression in a horse with chronic actinobacterial cranial nuchal bursitis

Equine Veterinary Education, EarlyView.
Summary A 14‐year‐old warmblood gelding was managed for waxing and waning cranial nuchal bursitis for 2 years. Intensive medical and surgical management was not curative, and the patient was subjected to euthanasia after becoming acutely recumbent. Ante‐mortem and post‐mortem next generation sequencing of bursal tissue and post‐mortem conventional PCR ...
H. Mesch, C. Frank, J. B. Daniels, E. Acutt, E. Contino   +4 more
wiley   +1 more source