Results 101 to 110 of about 272,563 (343)

The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCs) - Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2 [PDF]

, 2001
Toll-like receptors (TLRs) have been found to be key elements in pathogen recognition by the host immune system. Dendritic cells (DCs) are crucial for both innate immune responses and initiation of acquired immunity.
Aicher, A, Dimmeler, S, Hartung, T, Kirschning, CJ, Michelsen, KS, Mohaupt, M, Schumann, RR   +6 more
core   +1 more source

Role of TLR4 in the gut-brain axis in Parkinson’s disease: a translational study from men to mice

Gut, 2018
Objective Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases.
P. Perez‐Pardo, H. Dodiya, P. Engen, C. Forsyth, Andrea M Huschens, M. Shaikh, Robin M. Voigt, A. Naqib, S. Green, J. Kordower, K. Shannon, J. Garssen, A. Kraneveld, A. Keshavarzian   +13 more
semanticscholar   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Analysis of haplotypes of CAT, TLR4, and IL10 genes in bronchial asthma patients comorbid with arterial hypertension

Сибирский научный медицинский журнал, 2020
Co-occurrence of cardiovascular diseases is significantly common among patients with bronchial asthma. Genetic factors can have a significant effect on the development of hypertension in patients with asthma. Objective of the study was to investigate the
E. Y. Bragina, I. A. Goncharova, M. B. Freidin, I. Zh. Zhalsanova, D. E. Gomboeva, E. V. Nemerov, V. P. Puzyrev   +6 more
doaj   +1 more source

Neutrophil Extracellular Traps Promote Inflammatory Responses in Psoriasis via Activating Epidermal TLR4/IL-36R Crosstalk

Frontiers in Immunology, 2019
Epidermal infiltration of neutrophils is a hallmark of psoriasis, where their activation leads to release of neutrophil extracellular traps (NETs). The contribution of NETs to psoriasis pathogenesis has been unclear, but here we demonstrate that NETs ...
S. Shao, H. Fang, E. Dang, K. Xue, Jieyu Zhang, Bing Li, Hongjiang Qiao, T. Cao, Y. Zhuang, S. Shen, Tongmei Zhang, Pei Qiao, Caixia Li, J. Gudjonsson, Gang Wang   +14 more
semanticscholar   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Platelet TLR4 [PDF]

Circulation Research, 2014
Platelets are small, disc-shaped cell fragments that circulate in the blood and play an important role in hemostasis. The lifespan of a platelet is ≈5 to 9 days. Emerging evidence indicates that platelets may be involved in the pathogenesis of pulmonary arterial hypertension (PAH).
openaire   +2 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Fecal Microbiota Transplantation Alleviated Paclitaxel-Induced Peripheral Neuropathy by Interfering with Astrocytes and TLR4/p38MAPK Pathway in Rats

Journal of Pain Research, 2023
Haibin Shi,1 Minmin Chen,2 Caihong Zheng,2 Bian Yinglin,2 Bin Zhu2 1Department of Anesthesiology, the Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Department of ...
Shi H, Chen M, Zheng C, Yinglin B, Zhu B
doaj  

The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway

International Journal of Molecular Sciences, 2018
Toll-like receptors (TLRs) are a well-known family of pattern recognition receptors that play an important role in a host immune system. TLR triggering leads to the induction of pro-inflammatory cytokines and chemokines, driving the activation of both ...
Chung-Yi Chen, C. Kao, Chi-Ming Liu
semanticscholar   +1 more source