Results 121 to 130 of about 272,563 (343)

Impact of Human Toll-Like Receptor 4 Gene Polymorphism on Infection with Trichomonas vaginalis

Medical Journal of Babylon
Background: Trichomonas vaginalis (T. vaginalis) is an anaerobic protozoan characterized by functional diagnostic flagella which are important motility tools.
Zainab Waddah Kermasha, Hayam Khalis Al-Masoudi, Suhaila Fadhil Mohammed   +2 more
doaj   +1 more source

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model

, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
core   +2 more sources

Lipopolysaccharide and toll-like receptor 4 in dogs with congenital portosystemic shunts [PDF]

, 2015
Surgical attenuation of a congenital portosystemic shunt (CPSS) results in increased portal vein perfusion, liver growth and clinical improvement. Portal lipopolysaccharide (LPS) is implicated in liver regeneration via toll-like receptor (TLR) 4 mediated
House, A K, Lipscomb, V J, Smith, K C, Tivers, M S, Wheeler-Jones, C P D   +4 more
core   +4 more sources

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Probiotics Alleviate Chemotherapy-Associated Intestinal Mucosal Injury via the TLR4–NFκB Signaling Pathway

Drug Design, Development and Therapy, 2023
Xiaochong Li,1,* Bowen Hu,1,* Jiachen Zheng,2,3 Zhiyong Pan,1 Yuxiang Cai,4 Mingjuan Zhao,1 Xiaoqing Jin,2 Zhi-Qiang Li1 1Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, People’s Republic of China ...
Li X, Hu B, Zheng J, Pan Z, Cai Y, Zhao M, Jin X, Li ZQ   +7 more
doaj  

A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1-polarizing activity [PDF]

, 2017
Fasciolosis is a trematode zoonosis of interest in public health and cattle production. We report here the immunostimulatory effect of a 66 mer mucin-like peptide from Fasciola hepatica (Fhmuc), which synergizes with lipopolysaccharide (LPS) to promote ...
Brossard, Natalie, Carmona, Carlos, Dergan Dylon, Leonardo Sebastian, Freire, Teresa, Noya, Verónica, Rabinovich, Gabriel Adrián, Rodríguez, Ernesto   +6 more
core   +1 more source

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)

Journal of Experimental Medicine, 1999
Bacterial lipopolysaccharide (LPS) provokes a vigorous, generalized proinflammatory state in the infected host. Genetic regulation of this response has been localized to the Lps locus on mouse chromosome 4, through study of the C3H/HeJ and C57BL/10ScCr ...
S. Qureshi, L. Larivière, G. Leveque, S. Clermont, K. J. Moore, P. Gros, D. Malo   +6 more
semanticscholar   +1 more source

Epithelial TRIM27 Inhibits Intestinal Inflammation in Ulcerative Colitis by the USP7/TRIM27‐IKK Double Negative‐Feedback

Advanced Science, EarlyView.
ABSTRACT The E3 ubiquitin ligase tripartite motif 27 (TRIM27) is a negative regulator of NF‐κB activation and the innate immune response, and TRIM27 deficiency significantly impairs dextran sulfate sodium (DSS)‐induced colitis. The function of TRIM27 in intestinal epithelial cells (IECs), the mechanism by which TRIM27 inhibits the NF‐κB pathway and its
Weimin Xu, Zhebin Hua, Zhujiang Dai, Shasha Zhang, Yihan Jiang, Wensong Ge, YingWei Chen, Zhongchuan Wang, Bing Zhang, Chen‐Ying Liu, Peng Du   +10 more
wiley   +1 more source

Heat shock protein 90 mediates the protective effects of vericiguat on myocardial ischemia/reperfusion injury by inhibiting toll-like receptor 4 and c-Jun N-terminal kinases [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): This study aimed to investigate whether vericiguat exerts a protective effect against myocardial ischemia-reperfusion injury (MIRI) by inhibiting toll-like receptor 4 (TLR4) and c-Jun N-terminal kinases (JNK) activation and whether heat ...
Sijie Pan, Junyan Chen, Dongxiao Wang, Jianjun Meng, Min Wang, Guoqiang Zhong, Zhi-Yu Zeng, Ronghui Tu   +7 more
doaj   +1 more source

Drift, not selection, shapes toll-like receptor variation among oceanic island populations [PDF]

, 2015
Understanding the relative role of different evolutionary forces in shaping the level and distribution of functional genetic diversity among natural populations is a key issue in evolutionary and conservation biology.
Acevedo-Whitehouse, Aguilar, Akira, Alcaide, Areal, Basu, Belvin, Betrán, Bollmer, Cabe, Chen, Cramp, Downing, Ekblom, England, Excoffier, Fornůsková, Frankham, Frankham, Garza, Gautschi, Girard, Goslee, Grueber, Grueber, Grueber, Grueber, Hall, Hartl, Hartmann, Hedrick, Hudson, Hughes, Illera, Jensen, Jiggins, Kalinowski, Keestra, Klein, Kryazhimskiy, Librado, Manly, Mikami, Miller, Misch, Murrell, Murrell, Nakajima, Ohta, Oliver, Outlaw, Piertney, Poltorak, Pond, Pond, Quéméré, R Development Core Team, Raymond, Richardson, Roach, Schröder, Sommer, Spurgin, Spurgin, Spurgin, Spurgin, Stephens, Sutton, Takeuchi, Tamura, Teacher, Trowsdale, Tschirren, Tschirren, Turner, Voelker, Winternitz, Wlasiuk, Yoneyama   +78 more
core   +2 more sources