Results 131 to 140 of about 274,305 (384)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Electronegative LDL Promotes Inflammation and Triglyceride Accumulation in Macrophages

Cells, 2020
Electronegative low-density lipoprotein (LDL) (LDL(−)), a modified LDL that is present in blood and exerts atherogenic effects on endothelial cells and monocytes.
Núria Puig, Lara Montolio, Pol Camps-Renom, Laia Navarra, Francesc Jiménez-Altayó, Elena Jiménez-Xarrié, Jose Luis Sánchez-Quesada, Sonia Benitez   +7 more
doaj   +1 more source

LPS-induced Pellino3 degradation is mediated by p62-dependent autophagy [PDF]

, 2012
Background: In macrophages Toll-like receptor 4 (TLR4) is activated in response to lipopolysaccharide (LPS) and induces proinflammatory cytokine expression. Therefore, mechanisms terminating proinflammatory gene expression are important.
Brüne, Bernhard, Eifler, Lisa, Heeg, Annika, Heide, Hermann, Knape, Tilo, Knethen, Andreas von, Kuchler, Laura   +6 more
core   +1 more source

Effects of the TLR4/Myd88/NF-κB Signaling Pathway on NLRP3 Inflammasome in Coronary Microembolization-Induced Myocardial Injury

Cellular Physiology and Biochemistry, 2018
Background/Aims: Coronary microembolization (CME) is a common complication of acute coronary syndrome (ACS) and percutaneous coronary intervention (PCI); Myocardial inflammation, caused by CME, is the main cause of cardiac injury.
Q. Su, Lang Li, Yu-han Sun, Huafeng Yang, Ziliang Ye, Jinmin Zhao   +5 more
semanticscholar   +1 more source

Platelet TLR4 [PDF]

Circulation Research, 2014
Platelets are small, disc-shaped cell fragments that circulate in the blood and play an important role in hemostasis. The lifespan of a platelet is ≈5 to 9 days. Emerging evidence indicates that platelets may be involved in the pathogenesis of pulmonary arterial hypertension (PAH).
openaire   +2 more sources

In Situ Engineering of Tumor Cells as Self‐Sustaining cDC1 Programming Factories for Effective Cancer Immunotherapy

Advanced Science, EarlyView.
The fused EV platform AS16‐EL@MPLA/p‐FX reprograms tumor cells into cytokine‐producing factories that continuously secrete XCL1 and FLT3L to recruit and differentiate cDC1s, while embedded MPLA activates them through TLR4 signaling and AS16 prevents their exhaustion, thereby enhancing antitumor immunity and establishing durable immune memory against ...
Shuiling Jin, Xiaoxi Wang, Bingyu Li, Xueqin Zhu, Zimai Liu, Jiao Lu, Yuanyuan Wei, Zixian Wu, Kai Li, Tiantian Zhang, Zonghong He, Pingping Zhu, Yuanming Qi, Benyu Liu, Hui Liu, Yongchao Wang, Zhenzhen Chen   +16 more
wiley   +1 more source

TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway

Open Life Sciences
Diabetic cardiomyopathy (DCM) is identified as a progressive disease that may lead to irreparable heart failure. Toll-like receptor (TLR) signaling is believed to be implicated in the pathogenesis of DCM.
Zhao Xiaolong, Zhang Jing, Xu Feng, Shang Longqi, Liu Qingquan, Shen Chunjian   +5 more
doaj   +1 more source

Flavanomarein Protects HT22 Cells by Inhibiting LPS-induced Inflammatory Activation of BV2 Cells

Shipin gongye ke-ji
Objective: To investigate the protective effects of flavonomaside on HT22 mouse hippocampal neuronal cells by inhibiting the inflammatory response induced by lipopolysaccharide (LPS) in mouse microglia (BV2) and elucidate the underlying mechanisms ...
Dongmei YANG, Xiaojun YANG, Mengying HU, Hasmul Hamulati, Lei JING, Dexiu ZHAO, Qinlan LIANG   +6 more
doaj   +1 more source

Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease: Phenotype-genotype correlations [PDF]

, 2005
AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD. METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included.
Altorjay, István, Ferenci, Péter, Gasztonyi, Beáta, Lakatos, László, Lakatos, Péter László, Molnár, Tamás, Mózsik, Gyula, Oesterreicher, Christoph, Papp, János, Reinisch, Walter, Szalay, Ferenc, Tulassay, Zsolt, Willheim-Polli, Claudia   +12 more
core   +1 more source

Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis

Acta Neuropathologica, 2018
Despite the wealth of genomic and transcriptomic data in Parkinson’s disease (PD), the initial molecular events are unknown. Using LD score regression analysis, we show significant enrichment in PD heritability within regulatory sites for LPS-activated ...
Craig D. Hughes, Minee L. Choi, Mina Ryten, L. Hopkins, A. Drews, J. Botía, Maria Iljina, M. Rodrigues, Sarah A Gagliano, S. Gandhi, C. Bryant, D. Klenerman   +11 more
semanticscholar   +1 more source