Results 141 to 150 of about 237,895 (332)

Novel mutations in the toll like receptor genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection [PDF]

, 2008
Toll like receptors play a central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in TLR1, TLR2 and TLR4 genes may change the PAMP reorganization ability which causes altered responsiveness to the bacterial pathogens.
Ivan Mikula Jr., Ivan Mikula Sr., Lucia Kisova, Mangesh Bhide, Michal Novak, Rastislav Mucha, Rostislav Skrabana   +6 more
core   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

Polymorphisms in TLR4 gene associated with risks of bovine mastitis development

Ветеринария сегодня
Introduction. Inflammatory mammary diseases in cows remain the most common challenge in dairy industry, notwithstanding the improved preventive measures and treatment schemes.
M. V. Bytov, Yu. A. Osipova, Ch. R. Yusupova, V. D. Zubareva   +3 more
doaj   +1 more source

The role of acetylation in TLR4‐mediated innate immune responses [PDF]

, 2013
Xiaolan Hu, Yingnian Yu, Y. Eugene Chin, Qiang Xia   +3 more
openalex   +1 more source

Cascade‐Responsive MXene@Cu‐MOF Heterostructure Integrates Antioxidant Activity, Infection Control, and Vascularization for Tracheal Repair

Advanced Science, EarlyView.
A cascade‐responsive MXene@Cu‐MOF/GelMA hydrogel is engineered as a “skeleton–backpack” platform for extensive tracheal repair. The MXene framework scavenges postoperative ROS and converts NIR light into mild hyperthermia, while the Cu‐MOF component provides pH/NIR‐responsive Cu2+ dosing for infection control, angiogenesis, and chondrogenesis.
Liang Guo, Yingran Shen, Jiaoyu Yi, Juanjuan Li, Ziming Wang, Erji Gao, Siqiang Zheng, Zhe‐Sheng Chen, Bo Tao   +8 more
wiley   +1 more source

Differentiation of Porcine TLR4 Gene Expression in Piglets of Different Ages [PDF]

, 2011
ZX Pan, Z. Chen, L. Liu, Yueping Cao, Kaihui Xie, Jie Yang, Xing Huang, Shuqing Wu, W.B. Bao   +8 more
openalex   +1 more source

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali, Nabiha Sbeih, Rachel Rignault‐Bricard, Johanna Bruce, Morgane Le Gall, Claire Heilbronner, Noemie de Cacqueray, Sofia Angyalosy, Melissa Taylor, Joséphine Brice, Mariane de Montalembert, Martina Bevacqua, Emilie‐Fleur Gautier, Olivier Hermine, Thiago Trovati Maciel   +14 more
wiley   +1 more source

OR6-001 - S100A12 as pro-inflammatory TLR4 ligand [PDF]

, 2013
Christoph Kessel, Helmut Wittkowski, Aloys Lüken, Toni Weinhage, Georg Varga, Thomas Vogl, Timo Wirth, Dorothee Viemann, P. Björk, MAD van Zoelen, Faekah Gohar, Geetha Srikrishna, Jonas Roth, Dirk Foell   +13 more
openalex   +1 more source

Aberrant Expression of TLR2, TLR7, TLR9, Splicing Variants of TLR4 and MYD88 in Chronic Lymphocytic Leukemia Patients [PDF]

, 2021
Katarzyna Skórka, Paulina Własiuk, Agnieszka Karczmarczyk, Krzysztof Giannopoulos   +3 more
openalex   +1 more source

Maintenance of homeostasis by TLR4 ligands

Frontiers in Immunology
Immunotherapy is renowned for its capacity to elicit anti-infective and anti-cancer effects by harnessing immune responses to microbial components and bolstering innate healing mechanisms through a cascade of immunological reactions. Specifically, mammalian Toll-like receptors (TLRs) have been identified as key receptors responsible for detecting ...
Masataka Oda, Hirofumi Yamamoto, Takashige Kawakami   +2 more
openaire   +3 more sources