Results 191 to 200 of about 175,490 (344)

Deciphering the catalytic and pharmacological mechanisms of Coptis chinensis herbzymes to renovate intestinal microenvironment for colitis alleviation

BMEMat, EarlyView.
The synthesized CCzymes possess both antioxidant enzyme activity and pharmacological properties inherent to Coptis chinensis. By their antioxidant enzyme activity, CCzymes can attenuate oxidative stress within the inflammatory region of ulcerative colitis (UC), while their pharmacological activity acts on macrophage polarization and the intestinal ...
Zhichao Deng, Can Li, Yujie Zhang, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Mingxin Zhang, Martina H. Stenzel, Kelong Fan, Mingzhen Zhang, Yanyan Jiang   +10 more
wiley   +1 more source

Harnessing chimeric antigen receptor macrophages against solid tumors

Cancer Communications, EarlyView.
Abstract Macrophages are prevalent in multiple tumors and exhibit diverse and potent functional activities. Therapeutic reprogramming of macrophage phenotypes represents a promising strategy for cancer immunotherapy. Engineering chimeric antigen receptors (CARs) to endow macrophages with anti‐tumor capacities demonstrated encouraging efficacy ...
Mengru Wang, Zhen Qin, Xiu‐Wu Bian, Yu Shi   +3 more
wiley   +1 more source

The EZH2 Inhibitor GSK126 Alleviates Thromboinflammation in Deep Vein Thrombosis by Suppressing TLR4 Signaling via H3K27me3 Modulation. [PDF]

J Inflamm Res
Zhou R, Luo J, Zheng H.
europepmc   +1 more source

A Lipopolysaccharide‐Deficient Mutant ofNeisseria meningitidisElicits Attenuated Cytokine Release by Human Macrophages and Signals via Toll‐like Receptor (TLR) 2 but Not via TLR4/MD2

, 2001
Alison C. Pridmore, David Wyllie, Fatumo Abdi Abdillahi, Liana Steeghs, Peter van der Ley, Steven Dower, Robert C. Read   +6 more
openalex   +1 more source

LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF [PDF]

, 2003
Katherine A. Fitzgerald, Daniel C. Rowe, Betsy Barnes, Daniel R. Caffrey, Alberto Visintin, Eicke Latz, Brian G. Monks, Paula M. Pitha, Douglas T. Golenbock   +8 more
openalex   +1 more source

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, EarlyView.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source

Toxoplasma gondii-induced adverse pregnancy outcomes: insight into the inhibitory role of Trem2 on TLR4/TRAF6/JNK signaling pathway. [PDF]

Parasit Vectors
Cao Y, Fu F, Ju F, Wu C, Yao T, Yang M, Sun B, Chen J.   +7 more
europepmc   +1 more source

Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages [PDF]

, 2003
Angela Meier, Carsten J. Kirschning, Thomas Nikolaus, Hermann Wagner, J Heesemann, Frank Ebel   +5 more
openalex   +1 more source

Oxidative Stress Modulation and Antileishmanial Activity of Salvinia auriculata

Chemistry &Biodiversity, EarlyView.
Ethanolic extract of Salvinia auriculata showed significant antioxidant and antileishmanial activities. Salviniside II, the major metabolite, was isolated, structurally characterized, and evaluated, but exhibited weaker antiparasitic effects when compared to the whole extract.
Augusto César Rodrigues, Emilha Uzum Papaya, Fernanda da Silva, Carla Cardozo Pinto de Arruda, Edson Lucas dos Santos, Kely de Picoli Souza, Carlos Alexandre Carollo   +6 more
wiley   +1 more source

ALKBH5 exacerbates early cardiac damage after radiotherapy for breast cancer via m6A demethylation of TLR4. [PDF]

Open Life Sci
Yasen X, Maihesumu Y, Wusiman D, Aihemaiti A, Aishan X, Mushajiang M.   +5 more
europepmc   +1 more source