Adjuvant activity of a small molecule TLR4 agonist discovered via structure-based virtual screening. [PDF]
Kadivella M +5 more
europepmc +1 more source
Overexpression of CD14, TLR4, and MD-2 in HEK 293T cells does not prevent induction of in vitro endotoxin tolerance [PDF]
Andrei E. Medvedev, Stefanie N. Vogel
openalex +1 more source
Otitis media (OM) is a middle ear infection driven by chronic inflammation, leading to tissue damage and complications such as cholesteatoma. Flavonoids, a class of polyphenols with anti‐inflammatory properties, suppress key inflammatory mediators, reducing neutrophilic infiltration and mucosal thickening. These findings suggest flavonoids as potential
Madiha Ajaz +3 more
wiley +1 more source
HMGB1 regulates autophagy via TLR4/NF-κB signaling pathway in myocardial injury induced by coronary microembolization. [PDF]
Yang T, Wu X, Wang X.
europepmc +1 more source
TLR4-dependent Lipopolysaccharide-induced Shedding of Tumor Necrosis Factor Receptors in Mouse Bone Marrow Granulocytes [PDF]
Thierry Pédron +2 more
openalex +1 more source
Polysaccharides derived from medicine‐food plants restore intestinal barrier integrity and microbiota balance while modulating short‐chain fatty acid levels. These modifications significantly alleviate diabetes and its complications, including nephropathy, retinopathy, cardiovascular disease, and neuropathy.
Yi Long +13 more
wiley +1 more source
Interaction between toll-like receptor 4 polymorphism and abdominal obesity on ovarian cancer risk in Chinese women. [PDF]
Zhu J +5 more
europepmc +1 more source
Tea and Blood–Brain Barrier Homeostasis: Potential Mechanisms and Improvement Strategies
Abstract The blood–brain barrier (BBB), a selective interface regulating cerebral substance exchange, plays a crucial role in maintaining cognitive function and metabolic balance. While tea consumption has been traditionally associated with health benefits, its specific effects on BBB integrity warrant systematic investigation. This review demonstrates
Rongbosen Yue +5 more
wiley +1 more source
Real-time monitoring with iTLR4 assay identifies ligand-dependent TLR4-TLR4 conformational dynamics. [PDF]
Mustafa S, Evans SG, Hutchinson MR.
europepmc +1 more source

