Results 221 to 230 of about 135,891 (264)

Regulators of TLR4 Signaling by Endotoxins

2010
The stimulation of TLR4 by LPS activates two distinct signaling pathways leading to the expression of diverse inflammatory genes. Intensive studies over the past decade have revealed the components involved in these signaling pathways, however, more recently the focus has shifted somewhat towards the components that regulate these pathways.
Anne F, McGettrick, Luke A J, O'Neill
openaire   +2 more sources

TLR4 and LPS hyporesponsiveness in humans

International Journal of Hygiene and Environmental Health, 2002
Asthma is a complex genetic disorder that is caused by a number of unique gene-gene and gene-environment interactions. The search for asthma susceptibility genes has been complicated by the broad clinical phenotype of asthma, the polygenic inheritance pattern of this disease, and the substantial role of environmental exposures in the development and ...
openaire   +2 more sources

TLR4 as the Mammalian Endotoxin Sensor

2002
For more than a century, the ability to sense endotoxin (later known also as lipopolysaccharide; LPS) stood as the archetypal innate immune response: even before the phrase 'innate immunity' became popular. Yet the mechanism by which LPS initiated a signal remained unknown.
openaire   +2 more sources

Cigarette Smoke Upregulates TLR4 Expression and Enhances TLR4 Mediated Responses

2006
A key component of the innate defence mecbanisms against infections is represented by the tolllike receptor (TLR) family. We explored the role played by TLR4 in the pathogenesis of chronic obstructive pulmonary disease (COPD). We first assessed TLR4 expression by immunohystochemistry in surgical specimens from current and former smoker COPDs, from ...
PACE E, FERRARO M, MINERVINI MI, CHIAPPARA G, SIENA L, PIPITONE L, MELIS MR, MONTALBANO AM, BONSIGNORE MR, BELLIA V, BONSIGNORE G, GJOMARKAJ M   +11 more
openaire   +3 more sources

Move Over, TLR4

Science, 2013
Cytoplasmic lipopolysaccharide from Gram-negative bacteria can activate the innate immune system directly.
openaire   +2 more sources

Intracellular TLR4 Signaling

2020
Intracellular part of TLR4 signaling starts on the inner side of the cytoplasm and consists of two branches, namely, TLR4/TRIF/IRF3 and TLR4/MyD88/NF-κB. Through complex interactions including phosphorylation and ubiquitination, they lead to the activation of various transcription factors and are intrinsically regulated.
openaire   +1 more source

?????????????????????? 896A/G ???????? TLR4, ?? ???? 1196C/T ???????? TLR4 ???? 2258G/A ???????? TLR2 ???????????????? ???????????? ???? ?????????????????????? ?????????????? ???????????????????? ?????????????????? ?? ??????????

2017
1196C/T ???????? TLR4 ?????????? ?????????? ?????????????? ?????????????????????? ???????????????????? (????) ???? ?????????????????? ?? ?????????????? ????????????????. ?? ???????????????????? ?????????????? ?????????????????????????? ?????????????????? ?? ?????????????? ?????????? TLR2 ?? TLR4 ??????????????????????, ?????? ?????????????????? ????????
openaire   +2 more sources

Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis

Acta Pharmacologica Sinica, 2021
Jun Ren, Ying Tan
exaly  

Intestinal TLR4 deletion exacerbates acute pancreatitis through gut microbiota dysbiosis and Paneth cells deficiency

Gut Microbes, 2022
Zeng Yue
exaly  

Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2

Proceedings of the National Academy of Sciences of the United States of America, 2023
Judy Lieberman, , Mei Shenglin
exaly