Results 251 to 260 of about 222,436 (284)

Atractylenolide I alleviates the experimental allergic response in mice by suppressing TLR4/NF-kB/NLRP3 signalling

Open Life Sciences
Cai Weiran, Zhang Zhijun, Shi Chenyan, Sun Ru, Ju Han, Dong Xuelin, Teng Lei   +6 more
doaj   +1 more source

Integrative in vitro and in silico evaluation of HSP60-derived peptides as immunomodulators of the TLR4/MD-2 complex. [PDF]

Sci Rep
Vila-Casahonda RG, Lozano-Aponte J, Fragoso-Medina JA, Zúñiga-Ramos JA, García N, Guerrero-Beltrán CE.   +5 more
europepmc   +1 more source

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TLR4 biased small molecule modulators

Pharmacology & Therapeutics, 2021
Biased pharmacological modulators provide potential therapeutic benefits, including greater pharmacodynamic specificity, increased efficiency and reduced adverse effects. Therefore, the identification of such modulators as drug candidates is highly desirable.
Lin, C., Wang, H., Zhang, M., Mustafa, S., Wang, Y., Li, H., Yin, H., Hutchinson, M.R., Wang, X.   +8 more
openaire   +3 more sources

Circ-TLR4 promotes cardiac hypertrophy through recruiting FUS to stabilize TLR4 mRNA

Journal of Interventional Cardiac Electrophysiology, 2022
Cardiac hypertrophy is an adaptive and compensatory mechanism preserving cardiac output during detrimental stimuli. Circular RNAs (circRNAs) have been illustrated to exert important implications in the pathogenesis of multiple cardiovascular diseases (CVD) including demonstrated cardiac hypertrophy.
Chao Li, Jingwen Wang, Jun Feng, Jiangrong Zhou, Linlin Hou, Yu Gao, Ziping Cheng   +6 more
openaire   +2 more sources

Move Over, TLR4

Science, 2013
Cytoplasmic lipopolysaccharide from Gram-negative bacteria can activate the innate immune system directly.
openaire   +2 more sources

TLR4 polymorphisms and disease susceptibility

Inflammation Research, 2012
Toll-like receptors (TLRs) play a central role in the regulation of the host immune system. Each TLR recognizes specific pathogen-associated molecular patterns (PAMPs). TLR4 is one of the well characterized pathogen recognition receptors (PRRs) that recognizes the lipopolysaccharide (LPS) of Gram-negative bacteria, some conserved structures from fungal
Mamoona, Noreen, Muhammad Ali A, Shah, Sheeba Murad, Mall, Shazia, Choudhary, Tahir, Hussain, Iltaf, Ahmed, Syed Fazal, Jalil, Muhammad Imran, Raza   +7 more
openaire   +2 more sources