Results 291 to 300 of about 175,490 (344)

Passivation‐Engineered Zinc Peroxide Nanoparticles as Th1‐Biased Adjuvant for Antitumor Immunity

Small, EarlyView.
This study demonstrates passivated zinc peroxide nanoparticles (p‐ZPNs) as a novel class of Th1‐biased adjuvants to boost the efficacy of cancer vaccines. The p‐ZPNs exhibit excellent cellular uptake, low cytotoxicity, efficient endosome escape and intrinsic capability for triggering TLR/MyD88/NF‐κB axis, leading to robust T cell immunity.
Jiangqi Luo, Yue Wang, Zan Dai, Yiru Shi, Weixi Wu, Jingjing Qu, Yuening Zhong, Jianqiao Xian, Chengzhong Yu, Yannan Yang   +9 more
wiley   +1 more source

RETRACTION: TLR4 Modulates Senescence and Paracrine Action in Placental Mesenchymal Stem Cells via Inhibiting Hedgehog Signaling Pathway in Preeclampsia. [PDF]

Oxid Med Cell Longev
Cellular Longevity OMA.
europepmc   +1 more source

Bioengineered Extracellular Vesicles in Emerging Cancer Vaccine Platforms

Small Science, EarlyView.
This review highlights recent advances in engineering extracellular vesicles (EVs) as next‐generation cancer vaccines. It outlines their biological roles and antigen‐presenting capacity, explores key strategies for antigen loading and delivery optimization, and summarizes preclinical and clinical applications using EVs from diverse immune and tumor ...
Wonkyung Ahn, Yeram Lee, Gi‐Hoon Nam, Jae Bem You, Eun Jung Lee   +4 more
wiley   +1 more source

Gut Microbiota Mediator Level and Its Relation to Disease Activity in Ankylosing Spondylitis. [PDF]

Arch Rheumatol
Nasrallah H, Altındağ Ö, Akaltun MS, Bozdayı MA, Örkmez M, Balbal E, Gür A.   +6 more
europepmc   +1 more source

Brain‐Targeted Multifunctional Liposomes Reprogram Microglia via Anti‐Inflammatory Signaling and Reactive Oxygen Species Scavenging to Treat Post‐Traumatic Neuroinflammation

Small Structures, EarlyView.
Excessive inflammatory microglial cells in traumatic brain injury (TBI) site is a major driver of postinjury chronic neuroinflammation. A nanointegrative strategy is reported that enables efficient remodeling of TBI‐residing microglial cell fate specification through cooperative inhibition of NF‐κB/MAPK/TLR4 signaling and reactive oxygen species ...
Xuan Wang, Zhiqi Hu, Youbo Zhao, Yang Fei, Menghuan Li, Min Su, Zhong Luo, Rong Hu   +7 more
wiley   +1 more source

Decoding the relationship between oxidative stress and antiseizure medications using network pharmacology and molecular docking. [PDF]

Sci Rep
Desai M, Singh SD, Nagamani S, Malik S, Singh A, Kukreti R, Kukreti S, Grewal GK.   +7 more
europepmc   +1 more source

Nanotechnology and cell death: Revolutionizing disease treatment with nanoparticle strategies

VIEW, EarlyView.
Traditional disease treatments often face issues such as poor drug targeting and significant side effects, with many complex diseases lacking effective therapies. Our research utilizes tiny nanomaterials to treat diseases by regulating natural cell death processes, improving the immune environment, etc., enabling drugs to act more precisely.
Yiwen Wan, Wangzheqi Zhang, Yan Liao, Chenglong Zhu, Xiaojing Guo, Zui Zou, Mi Li   +6 more
wiley   +1 more source

Dual role of TLR4 in bacterial meningitis through regulating endothelial pyroptosis and inflammatory response during extraintestinal pathogenic <i>Escherichia coli</i> infection. [PDF]

Front Immunol
Jia K, Du Y, Lin W, Cao X, Zhang J, Peng L, Li Z, Fang R.   +7 more
europepmc   +1 more source

Current Insights Into Individualized Diagnosis and Treatment of Allergic Rhinitis Based on Phenotype and Endotype

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa characterized by allergen sensitization and the involvement of multiple inflammatory mediators. Currently, the treatment of AR mainly includes symptomatic relief, anti‐inflammatory therapy, and nerve desensitization. However, these treatments have limitations in fully
Yue Gu, Long‐Lan Shu, Tao Lu, Da‐Yu Guan, Bo‐Wen Zheng, Pan‐Hui Xiong, Yang Shen, Yu‐Cheng Yang   +7 more
wiley   +1 more source

Altered microRNA expression correlates with reduced TLR2/4-dependent periodontal inflammation and bone resorption induced by polymicrobial infection. [PDF]

Microbiol Spectr
Jeepipalli S, Gurusamy P, Martins ARL, Colella E, Nadakuditi SR, Desaraju T, Yada A, Onime J, William JT, Bhattacharyya I, Chan EKL, Kesavalu L.   +11 more
europepmc   +1 more source