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BGN Secreted by Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression via Activation of TLR4-Mediated Erk and NF-κB Signaling Pathways. [PDF]

open access: yesInt J Mol Sci
Yokoo H   +11 more
europepmc   +1 more source
Some of the next articles are maybe not open access.

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TLR4 biased small molecule modulators

Pharmacology & Therapeutics, 2021
Biased pharmacological modulators provide potential therapeutic benefits, including greater pharmacodynamic specificity, increased efficiency and reduced adverse effects. Therefore, the identification of such modulators as drug candidates is highly desirable.
Lin, C.   +8 more
openaire   +3 more sources

Circ-TLR4 promotes cardiac hypertrophy through recruiting FUS to stabilize TLR4 mRNA

Journal of Interventional Cardiac Electrophysiology, 2022
Cardiac hypertrophy is an adaptive and compensatory mechanism preserving cardiac output during detrimental stimuli. Circular RNAs (circRNAs) have been illustrated to exert important implications in the pathogenesis of multiple cardiovascular diseases (CVD) including demonstrated cardiac hypertrophy.
Chao Li   +6 more
openaire   +2 more sources

Move Over, TLR4

Science, 2013
Cytoplasmic lipopolysaccharide from Gram-negative bacteria can activate the innate immune system directly.
openaire   +2 more sources

TLR4 polymorphisms and disease susceptibility

Inflammation Research, 2012
Toll-like receptors (TLRs) play a central role in the regulation of the host immune system. Each TLR recognizes specific pathogen-associated molecular patterns (PAMPs). TLR4 is one of the well characterized pathogen recognition receptors (PRRs) that recognizes the lipopolysaccharide (LPS) of Gram-negative bacteria, some conserved structures from fungal
Mamoona, Noreen   +7 more
openaire   +2 more sources

LPS/TLR4 signal transduction pathway

Cytokine, 2008
The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years.
Yong-Chen, Lu   +2 more
openaire   +2 more sources

Can MMTV exploit TLR4?

Trends in Microbiology, 2002
The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response.
Susan R Ross, John C Rassa
openaire   +3 more sources

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