The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li +4 more
wiley +1 more source
The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Environmental pollution and climate change seriously affect human health, leading to the onset and exacerbation of chronic respiratory diseases, such as allergic rhinitis and lung diseases. Over the past several decades, increasing air pollution and environmental exposure owing to global urbanization, industrialization, and rapid economic ...
Xin‐Yan Liu +4 more
wiley +1 more source
Donkey Milk Improves Dextran Sulfate Sodium-Induced Ulcerative Colitis by Protecting Gut Barrier Function, Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway, and Modulating Gut Microbiota. [PDF]
Food Sci NutrYang L +7 more
europepmc +1 more source
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective To assess foetal circulating free foetal haemoglobin (fHbF) levels and heme defences, correlated to foetal circulatory biometry and foetal sex in severe early‐onset foetal growth restriction (FGR). Design, Setting and Population A prospective study severe early‐onset foetal growth restriction pregnancies with close clinical ...
Adam Brook +17 more
wiley +1 more source
Modulating Receptor Activity, Immune Response, and Kinetic Solubility: The Impact of Linker Chemistry in Conjugated NOD2/TLR4 Agonists. [PDF]
ACS OmegaParadiso E, Janež Š, Jakopin Ž.
europepmc +1 more source
Aging Cell, EarlyView.We aimed to uncover the molecular mechanisms linking age‐related pain susceptibility with cognitive decline in Alzheimer's disease (AD). By integrating transcriptomic, human AD brain, genomic, and Mendelian randomization analyses, we identified the lipid‐modifying enzyme LPCAT2 as a sex‐ and APOE genotype–dependent causal mediator of both heightened ...
Rai‐Hua Lai +6 more
wiley +1 more source
Endotoxin's Impact on Organism: From Immune Activation to Tolerance and Beyond. [PDF]
J Clin MedRoszak K +5 more
europepmc +1 more source
Bone Loss and TLR4 Signals Contribute Independently to B Lineage Aging
Aging Cell, EarlyView.The prevailing view is that the age‐related decline of B lymphopoiesis is due to increased inhibitory signals in the marrow environment. Our data show that the loss of salutary ones, such as those from bone, primarily drives the loss of B cell progenitors with age.
Erin Baker +6 more
wiley +1 more source
Lithocholic acid ameliorates ulcerative colitis via the PXR/TLR4/NF-κB/NLRP3 signaling pathway and gut microbiota modulation. [PDF]
Cell Mol Life SciLiu Y +6 more
europepmc +1 more source
A chronic Acinetobacter baumannii pneumonia model to study long-term virulence factors, antibiotic treatments, and polymicrobial infections. [PDF]
Nat CommunJackson-Litteken CD +8 more
europepmc +1 more source