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BGN Secreted by Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression via Activation of TLR4-Mediated Erk and NF-κB Signaling Pathways. [PDF]
Yokoo H +11 more
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Retraction: Paper "MiR-590 Inhibits Endothelial Cell Apoptosis by Inactivating the TLR4/NF-κB Pathway in Atherosclerosis" by Lei Yang and Chuanyu Gao [Yonsei Med J 2019;60(3):298-307]. [PDF]
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TLR4 biased small molecule modulators
Pharmacology & Therapeutics, 2021Biased pharmacological modulators provide potential therapeutic benefits, including greater pharmacodynamic specificity, increased efficiency and reduced adverse effects. Therefore, the identification of such modulators as drug candidates is highly desirable.
Lin, C. +8 more
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Circ-TLR4 promotes cardiac hypertrophy through recruiting FUS to stabilize TLR4 mRNA
Journal of Interventional Cardiac Electrophysiology, 2022Cardiac hypertrophy is an adaptive and compensatory mechanism preserving cardiac output during detrimental stimuli. Circular RNAs (circRNAs) have been illustrated to exert important implications in the pathogenesis of multiple cardiovascular diseases (CVD) including demonstrated cardiac hypertrophy.
Chao Li +6 more
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Science, 2013
Cytoplasmic lipopolysaccharide from Gram-negative bacteria can activate the innate immune system directly.
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Cytoplasmic lipopolysaccharide from Gram-negative bacteria can activate the innate immune system directly.
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TLR4 polymorphisms and disease susceptibility
Inflammation Research, 2012Toll-like receptors (TLRs) play a central role in the regulation of the host immune system. Each TLR recognizes specific pathogen-associated molecular patterns (PAMPs). TLR4 is one of the well characterized pathogen recognition receptors (PRRs) that recognizes the lipopolysaccharide (LPS) of Gram-negative bacteria, some conserved structures from fungal
Mamoona, Noreen +7 more
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LPS/TLR4 signal transduction pathway
Cytokine, 2008The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years.
Yong-Chen, Lu +2 more
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Trends in Microbiology, 2002
The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response.
Susan R Ross, John C Rassa
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The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response.
Susan R Ross, John C Rassa
openaire +3 more sources

