Results 301 to 310 of about 262,724 (386)

TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy. [PDF]

Genes Dis
Luo R, Miao Y, Hu R, Lin F, Yan J, Yang T, Xiao L, Sun Z, Wang Y, Chen J.   +9 more
europepmc   +1 more source

Akkermansia muciniphila‐derived hypoacylated rough‐type lipopolysaccharides alleviate diet‐induced obesity via activation of TLR4−IL‐23−IL‐22 immune axis

iMeta, EarlyView.
This study demonstrates that hypoacylated, rough‐type lipopolysaccharides (LPS) derived from Akkermansia muciniphila strain HW07 (ALPS) alleviates diet‐induced obesity. ALPS acts as a weak TLR4 agonist and significantly reduces weight gain, improves metabolic parameters, and restores gut barrier integrity in obese mice.
Li Sun, Yuting Zhang, Wang Dong, Jingzu Sun, Tao Wang, Fei Shao, Huanqin Dai, Junjie Han, Wenzhao Wang, Shuo Wang, Tong Zhao, Liangliang Wang, Chang Liu, Shuangjiang Liu, Hongwei Liu   +14 more
wiley   +1 more source

Bromodomain-containing protein 4 contributes to chronic postsurgical pain via activating TLR4/NF-kappaB-dependent neuroinflammation. [PDF]

BMC Anesthesiol
Shu R, Li Y, Zhang Z, Zhang X, Guan S, Wang K, Yin Y.   +6 more
europepmc   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

Interdisciplinary Medicine, EarlyView.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang, Yufei Yang, Bingxu Chen, Yanmeng Zhao, Haitao Sun   +4 more
wiley   +1 more source

Do NGF and LPS Interact Synergistically to Modulate Inflammation in Sheep Endometrial Epithelial Cells? [PDF]

Int J Mol Sci
Guelfi G, Capaccia C, Ratto VF, Dall'Aglio C, Mercati F, Maranesi M.   +5 more
europepmc   +1 more source

TOLL-LIKE RECEPTOR 4 (TLR4) COUPLED GI PROTEIN SIGNALING PATHWAYS ACTIVATE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK1/2) PHOSPHORYLATION INDEPENDENT OF NFκB ACTIVATION

, 2003
Hongmei Fan, Octavia M. Peck, S. Sprunger, G Tempel, Perry V. Halushka, James A. Cook   +5 more
openalex   +1 more source

GATA1 Transcriptionally Upregulates LMCD1, Promoting Ferroptosis in Sepsis‐Associated Acute Kidney Injury Through the Hippo/YAP Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) is associated with morbidity and mortality. Ferroptosis is associated with the pathophysiology of SA‐AKI. Here, we investigated the role of LIM and cysteine‐rich domain 1 (LMCD1) in the regulation of ferroptosis during SA‐AKI progression.
You‐Qi Zhang, Wei‐Xia Peng, You‐Fu Li, Peng Lu, Hui Liu, Wen‐Guang Liu   +5 more
wiley   +1 more source

Hederasaponin C ameliorates chronic obstructive pulmonary disease pathogenesis by targeting TLR4 to inhibit NF-κB/MAPK signaling pathways. [PDF]

Chin Med
Ning Y, Huang L, Wang QQ, Liu L, Ni X, Xie X, Liu J, Su Q, Yang S, Yuan R, Gao H.   +10 more
europepmc   +1 more source

Faculty Opinions recommendation of LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.

, 2003
David M. Underhill
openalex   +2 more sources