Results 161 to 170 of about 74,934 (299)
International Journal of Molecular Sciences, 2019 Myelodysplastic Syndromes (MDSs) are bone marrow (BM) failure malignancies characterized by constitutive innate immune activation, including NLRP3 inflammasome driven pyroptotic cell death.
G. Ward +17 more
semanticscholar +1 more source
Advancements in Inorganic Chiral Nanomaterials for Anti‐Tumor Immunotherapy
Cancer Science, EarlyView.Schematic illustration of how inorganic chiral nanomaterials enhance immune activation to promote tumor cell elimination through targeted delivery, immunogenic cell death, and immune microenvironment modulation. ABSTRACT While the past decade has witnessed unprecedented technological advancements, cancer remains a major health threat, with conventional
Siyu Chen +9 more
wiley +1 more source
Nature Communications, 2018 Inflammation is a characteristic feature of Parkinson’s disease (PD). We examined the role of TLR9 and its regulation by glucocorticoid receptors (GRs) in degeneration of substantia nigra dopamine neurons (DNs).
L. Maatouk +14 more
semanticscholar +1 more source
The FEBS Journal, EarlyView.The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs +7 more
wiley +1 more source
Mediators of Inflammation, 2015 To investigate the correlation between TLR9 and cytokine secretion in SLE diagnosis and treatment. A total of 66 cases (39 SLE and 27 healthy donors) were enrolled in this study. The CD20+ labeled B cells were isolated from SLE patients.
Hui Rao +5 more
doaj +1 more source
TLR9 Turns the Tide on Treg Cells [PDF]
Immunity, 2008 In this issue of Immunity, Hall et al. (2008) demonstrate that commensal bacterial DNA can suppress Treg cell conversion via TLR9-mediated activation of lamina propria dendritic cells and thus potentially disrupt intestinal homeostasis.
openaire +4 more sources
Immunology, EarlyView.During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu +24 more
wiley +1 more source
Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines. [PDF]
, 2019 BACKGROUND:Astrocytes contribute to the crosstalk that generates chronic neuro-inflammation in neurological diseases; however, compared with microglia, astrocytes respond to a more limited continuum of innate immune system stimulants.
Azmoon, Pardis +8 more
core +1 more source
Phage Therapy: Targeting the Gut Microbiota for the Treatment of Acute Pancreatitis
Journal of Gastroenterology and Hepatology, EarlyView.ABSTRACT Acute pancreatitis (AP) is a common clinical inflammatory condition whose severity is closely associated with both local pancreatic injury and systemic complications. Research indicates that gut microbiota dysbiosis and subsequent bacterial translocation can exacerbate disease progression via the gut–pancreas axis, representing a critical ...
Jiawei Chen +4 more
wiley +1 more source
In Vivo TLR9 Inhibition Attenuates CpG-Induced Myocardial Dysfunction
Mediators of Inflammation, 2013 The involvement of toll-like receptor 9 (TLR9), a receptor for bacterial DNA, in septic cardiac depression has not been clarified in vivo. Thus, the aim of the study was to test possible TLR9 inhibitors (H154-thioate, IRS954-thioate, and chloroquine) for
O. Boehm +9 more
doaj +1 more source