Results 171 to 180 of about 46,527 (261)

Scaffold‐free three‐dimensional culture of chronic lymphocytic leukaemia preserves B–T‐cell cross‐talk and enables drug response profiling

British Journal of Haematology, Volume 209, Issue 3, Page 953-963, September 2026.
Summary Chronic lymphocytic leukaemia (CLL) presents a complex biological and clinical landscape, strongly influenced by the tumour microenvironment (TME). To better capture this heterogeneity, we have developed patient‐derived lymphoma spheroids from CLL samples (CLL‐PDLS), which recapitulate the cross‐talk between malignant cells and the autologous ...
Heribert Playa‐Albinyana, Ariadna Giró, Juan A. Piñeyroa, Ferran Araujo‐Ayala, Cèlia Dobaño‐López, Sara Otín‐Sánchez, Elías Campo, Christine Bezombes, Patricia Pérez‐Galán, Dolors Colomer   +9 more
wiley   +1 more source

Altered expression of Toll-like receptor 9 in the lung tissue of adult mice generated by in vitro embryo culture and embryo transfer. [PDF]

Histochem Cell Biol
Öztürk M, Doğan G, Karagenç L.
europepmc   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, Volume 59, Issue 9, September 2026.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Cancer immunotherapy targeting murine myeloid cells requires endosomal pattern recognition. [PDF]

Nat Commun
Pan Y, Pei S, Liang H, Westberg K, Nitschke L, Chen X, Yu Y, He N, Lin Q, Lei L, Gisterå A, Hartman J, Ravetch JV, Mak TW, McGaha TL, Karlsson MCI.   +15 more
europepmc   +1 more source

Activation of Anergic B Cells During Development of Autoimmunity

Immunological Reviews, Volume 342, Issue 1, September 2026.
ABSTRACT In healthy individuals, autoreactive B cells are normally silenced via central and peripheral tolerance mechanisms. In the periphery, when autoreactive B cells recognize self‐antigen via their B cell receptor (BCR) (signal 1) but do not receive T cell help (signal 2), they undergo the tolerance mechanism called anergy.
Mohammad Mansoor, Brandon K. Hilliard, Mia J. Smith   +2 more
wiley   +1 more source

Glycolysis Drives TLR Ligand-Induced Maturation and Immune Activation of Liver Sinusoidal Endothelial Cells. [PDF]

Liver Int
Shu Y, Yan H, Sun H, Gu X, Littwitz-Salomon E, Liu J, Wu J, Yang D, Zheng X, Lu M, Du Y.   +10 more
europepmc   +1 more source

Toll-like receptor 9 arginine methylation promotes ferroptosis in prostate cancer through the NRF2/GPX4 signaling pathway. [PDF]

Transl Androl Urol
Hua H, Tian Z, Zhou J, Wang F, Nong A, Yu N, Zhu Y, Wang H.   +7 more
europepmc   +1 more source

TLR7/9-mediated mucosal innate immune dysregulation in IgA nephropathy. [PDF]

Front Immunol
Lee M, Suzuki H, Makita Y, Suzuki Y.
europepmc   +1 more source

DNA oligonucleotides block viral entry of SARS-CoV-2 Omicron variants. [PDF]

PLoS Pathog
Acuña JA, Gabriel B, Ayyanathan K, Miller J, Li Y, Whig K, Zhu Y, McGrath M, Hewins P, Jurado KA, Frieman MB, Schultz DC, Cherry S.   +12 more
europepmc   +1 more source

Therapeutic Potential of Ginkgolic Acid C17:1 in Modulating PTEN/mtDNA/TLR9 Axis for Alleviating Chronic Pseudomonas Aeruginosa Infection in Bronchiectasis. [PDF]

Iran J Biotechnol
Rao S, Jiang H, Huang J, Li H, Yuan W, Chen L, Xie J, Xie C.   +7 more
europepmc   +1 more source