Results 51 to 60 of about 74,934 (299)

Toll-like receptor 9 suppresses lupus disease in Fas-sufficient MRL Mice. [PDF]

PLoS ONE, 2017
Genetic deficiency in TLR9 accelerates pathogenesis in the spontaneous polygenic MRL.Faslpr murine model of systemic lupus erythematosus, despite the absence of anti-nucleosome autoantibodies. However, it could be argued that this result was dependent on
Kevin M Nickerson, Yujuan Wang, Sheldon Bastacky, Mark J Shlomchik   +3 more
doaj   +1 more source

TLR9^−/− and TLR9^+/+ mice display similar immune responses to a DNA vaccine [PDF]

Immunology, 2004
SummaryPlasmid DNA continues to attract interest as a potential vaccine‐delivery vehicle. However, the mechanisms whereby immune responses are elicited by plasmids are not fully understood. Although there have been suggestions regarding the importance of CpG motifs in plasmid immunogenicity, the molecular mechanisms by which CpG motifs enhance immune ...
Shawn, Babiuk, Neeloffer, Mookherjee, Reno, Pontarollo, Phillip, Griebel, Sylvia, van Drunen Littel-van den Hurk, Rolf, Hecker, Lorne, Babiuk   +6 more
openaire   +2 more sources

DNA of neutrophil extracellular traps promote NF-κB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease

Signal Transduction and Targeted Therapy
Chronic obstructive pulmonary disease (COPD) is characterised by persistent airway inflammation even after cigarette smoking cessation. Neutrophil extracellular traps (NETs) have been implicated in COPD severity and acute airway inflammation induced by ...
Jun Chen, Tao Wang, Xiao-ou Li, Lijuan Gao, Ke Wang, Mengxin Cheng, Zijian Zeng, Lei Chen, Yongchun Shen, Fuqiang Wen   +9 more
semanticscholar   +1 more source

Hepatoma cell-intrinsic TLR9 activation induces immune escape through PD-L1 upregulation in hepatocellular carcinoma

Theranostics, 2020
A TLR9 agonist in combination with a PD-1 inhibitor produced powerful antitumor responses in a clinical trial despite TLR9 agonists as monotherapies failing to generate systemic antitumor immune responses due to immunosuppressive effects.
Binghai Zhou, Jiuliang Yan, Lei Guo, Bo Zhang, Shuang-Hu Liu, Mincheng Yu, Zheng Chen, Kewei Zhang, Wentao Zhang, Xiaoqiang Li, Yong-feng Xu, Yongsheng Xiao, Jian Zhou, Jia Fan, M. Hung, Hui Li, Q. Ye   +16 more
semanticscholar   +1 more source

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman, Erik Hrabovszky, Imre Kalló, István Likó, Miklós Sárvári, Nicole Berchtold, Norbert Solymosi, Sárvári, Miklós, Zsolt Liposits   +8 more
core   +2 more sources

Mitochondrial DNA Stimulates TLR9-Dependent NET Formation in Primary Graft Dysfunction.

American Journal of Respiratory Cell and Molecular Biology, 2020
The immune system is designed to robustly respond to pathogenic stimuli but to be tolerant to endogenous ligands to not trigger autoimmunity. Here, we studied an endogenous damage-associated molecular pattern, mitochondrial DNA (mtDNA), during primary ...
B. Mallavia, Fengchun Liu, Emma Lefrançais, S. Cleary, N. Kwaan, Jennifer J. Tian, M. Magnen, D. Sayah, A. Soong, Joy Chen, Rajan, Saggar, M. Shino, David J. Ross, A. Derhovanessian, Joseph P. Lynch, A. Ardehali, S. Weigt, J. Belperio, S. Hays, Jeffrey A. Golden, L. Leard, Rupal J. Shah, M. Kleinhenz, A. Venado, Jasleen, Kukreja, J. Singer, M. Looney   +28 more
semanticscholar   +1 more source

Toll-like receptor 9 is required for opioid-induced microglia apoptosis. [PDF]

PLoS ONE, 2011
Opioids have been widely applied in clinics as one of the most potent pain relievers for centuries, but their abuse has deleterious physiological effects beyond addiction.
Lei He, Hui Li, Lin Chen, Junying Miao, Yulin Jiang, Yi Zhang, Zuoxiang Xiao, Gregory Hanley, Yi Li, Xiumei Zhang, Gene LeSage, Ying Peng, Deling Yin   +12 more
doaj   +1 more source

Distinct immune signatures in directly treated and distant tumors result from TLR adjuvants and focal ablation. [PDF]

, 2018
Both adjuvants and focal ablation can alter the local innate immune system and trigger a highly effective systemic response. Our goal is to determine the impact of these treatments on directly treated and distant disease and the mechanisms for the ...
Borowsky, Alexander D, Chavez, Michael, Davis, Ryan R, Ferrara, Katherine W, Fite, Brett Z, Hubbard, Neil E, Ilovitsh, Asaf, Ingham, Elizabeth S, Mahakian, Lisa M, Monjazeb, Arta M, Murphy, William J, Silvestrini, Matthew T, Tam, Sarah M, Tepper, Clifford G   +13 more
core   +1 more source

Emerging role of endosomal toll-like receptors in rheumatoid arthritis [PDF]

, 2014
Toll-like receptors (TLRs) and their downstream signaling pathways have been comprehensively characterized in innate immunity. In addition to this function, these receptors have also been suggested to be involved in the pathogenesis of many autoimmune ...
Chamberlain, Giselle, Sacre, Sandra, Thwaites, Ryan   +2 more
core   +5 more sources

Cleavage of Toll-Like Receptor 9 Ectodomain Is Required for In Vivo Responses to Single Strand DNA

Frontiers in Immunology, 2018
Mouse toll-like receptor 9 (TLR9) is an endosomal sensor for single-stranded DNA. TLR9 is transported from the endoplasmic reticulum to endolysosomes by a multiple transmembrane protein Unc93 homolog B1, and proteolytically cleaved at its ectodomain. The
Ryutaro Fukui, Chikako Yamamoto, Fumi Matsumoto, Masahiro Onji, Masahiro Onji, Takuma Shibata, Yusuke Murakami, Yusuke Murakami, Atsuo Kanno, Takuto Hayashi, Natsuko Tanimura, Nobuaki Yoshida, Kensuke Miyake, Kensuke Miyake   +13 more
doaj   +1 more source