Results 81 to 90 of about 74,934 (299)

Toll-like Receptor 9 in Breast Cancer

Frontiers in Immunology, 2014
Toll-like receptor 9 (TLR9) is a cellular DNA receptor of the innate immune system. DNA recognition via TLR9 results in an inflammatory reaction, which eventually also activates a Th1-biased adaptive immune attack.
Katri eSelander, Katri eSelander, Jouko eSandholm   +2 more
doaj   +1 more source

TLR-9 Expression in Human Bronchial Epithelial Cells induced with Lipopolysaccharide [PDF]

, 2010
The study conducted here was to investigate the gene and protein expression of Toll like receptor 9 when human bronchial epithelial cells were induced by lipopolysaccharide.
Sangeetha Dharmalingam, Shanmuga Saravanabhavan   +1 more
core   +1 more source

DOCK8 Functions as an Adaptor that Links TLR–MyD88 Signaling to B Cell Activation [PDF]

, 2012
DOCK8 and MyD88 have been implicated in serologic memory. Here we report antibody responses were impaired and \(CD27^+\) memory B cells were severely reduced in DOCK8-deficient patients.
Al-Herz, Waleed, Baris, Safa, Barlan, Isil, Baxi, Sachin, Benson, Halli Louise, Borzutzky, Arturo, Ceja, Reuben, Chatila, Talal Amine, Dasouki, Majed, Dbaibo, Ghassan, Fitzgerald, Katerine, Geha, Raif Salim, Golenbock, Douglas, Jabara, Haifa Halim, Janssen, Erin Margaret, Kanariou, Maria, Keles, Sevgi, Kutukculer, Necil, Lefranc, Gerard, Manis, John P., Massaad, Michel, McDonald, Douglas Ray, Notarangelo, Luigi D., Ochs, Hans, Plebani, Alessandro, Ramesh, Narayanaswamy, Rauter, Ingrid, Recher, Mike, Reisli, Ismail, Schneider, Lynda C., Wakim, Rima   +30 more
core   +1 more source

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, EarlyView.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source

Absent Toll-like receptor-9 expression predicts poor prognosis in renal cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2011
Background Toll-like receptor 9 (TLR9) is a cellular DNA-receptor whose activation with cognate ligands triggers an immune reaction, with increased production of inflammatory cytokines. The aim of this study was to examine the expression of TLR9 in renal
Paavonen Timo K, Vuopala Katri S, Kauppila Saila, Hirvikoski Pasi, Ronkainen Hanna, Selander Katri S, Vaarala Markku H   +6 more
doaj   +1 more source

Safe and Localized Lentiviral Gene Delivery via Injectable Mesoporous Scaffolds for Potent Antitumor Immunity

Advanced Materials, EarlyView.
This work introduces an injectable mesoporous silica rod scaffold that confines lentiviral vectors to the injection site, enabling localized dendritic cell recruitment and transduction. The platform sustains antigen expression, promotes robust T‐cell activation, and enhances antitumor immunity.
Thanh Loc Nguyen, Yeon‐ju Kim, Jihye Im, Dong Kwang Min, Hyunsu Shin, Thuy An Trinh, Ngoc Man Phan, Min‐jeong Son, Ji‐yeon Shim, Ye‐lim Lee, Yujeong Ha, Kwang‐il Lim, Jaeyun Kim   +12 more
wiley   +1 more source

TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients

BMC Cancer, 2010
Background Our study aims to evaluate the expression of TLR9 in glioma tissues, examine the association between TLR9 expression, clinicopathological variables, and glioma patient outcome, we further characterized the direct effects of TLR9 agonist CpG ...
Jiang Tao, Ying Qiao, Yan Ying, Cao Shouqiang, Wang Chao, Xu Ke, Wu Anhua   +6 more
doaj   +1 more source

The role of TLR9 on Leishmania amazonensis infection and its influence on intranasal LaAg vaccine efficacy. [PDF]

PLoS Neglected Tropical Diseases, 2019
Leishmania (L.) amazonensis is one of the etiological agents of cutaneous leishmaniasis (CL) in Brazil. Currently, there is no vaccine approved for human use against leishmaniasis, although several vaccine preparations are in experimental stages.
Juliana Elena Silveira Pratti, Alessandra Marcia da Fonseca Martins, Juliana Paiva da Silva, Tadeu Diniz Ramos, Joyce Carvalho Pereira, Luan Firmino-Cruz, Diogo Oliveira-Maciel, Thiago Soares de Souza Vieira, Leandra Linhares Lacerda, Andre Macedo Vale, Celio G Freire-de-Lima, Daniel C Oliveira Gomes, Elvira M Saraiva, Bartira Rossi-Bergmann, Herbert Leonel de Matos Guedes   +14 more
doaj   +1 more source

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Natural killer cells as an initial defense against pathogens. [PDF]

, 2006
Natural killer (NK) cells serve as a crucial first line of defense against tumors and a diverse range of pathogens. Recognition of infection by NK cells is accomplished by the activation of receptors on the NK cell surface, which initiate NK cell ...
Lanier, Lewis L, Lodoen, Melissa B
core