Results 71 to 80 of about 148,110 (341)
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Exosomes: Potential Therapies for Disease via Regulating TLRs [PDF]
, 2020 Exosomes are small membrane vesicles that retain various substances such as proteins, nucleic acids, and small RNAs. Exosomes play crucial roles in many physiological and pathological processes, including innate immunity.
Hong-Yan Guo +4 more
core +1 more source
Infection of Human Macrophage-Like Cells by African Swine Fever Virus
Frontiers in Bioscience-LandmarkBackground: The African swine fever (ASF) virus (ASFV) and ASF-like viral sequences were identified in human samples and sewage as well as in different water environments. Pigs regularly experience infections by the ASFV.
Zaven A. Karalyan +9 more
doaj +1 more source
Journal of Leukocyte Biology, 2019 Abstract Discussion on TLR3 triggering in CD4 T cells induces IFN beta and IL10-producing iTregs that suppress food allergy.
openaire +3 more sources
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Autoimmunity, 2018 Therapeutic efficacy of P277 against type 1 diabetes was extensively investigated and clinically evidenced. Clinical trials Phases I and II concluded promising results, while the data of P277 immunogenicity in Phase III trials represented weak responses ...
Murad Alahdal +8 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
TLRs-triggered immune response was enhanced in Gpr108-null cells. [PDF]
, 2018 (A) Primary macrophage cells derived from litter mated Gp108+/+ and Gpr108-/- mice were treated with LPS (1 μg/ml, TLR4), Poly (I:C) (5 μg/ml, TLR3), immiquimod (50 μg/ml, TLR7) and R484 (10 μg/ml, TLR7).
Brian Seed (206836) +7 more
core +1 more source
A Cell Specific Effect of MBOAT7 MAFLD-risk Variant on Immune Cells
Frontiers in Bioscience-LandmarkBackground: Disease risk variants are likely to affect gene expression in a context- and cell-type specific manner. The membrane bound O-acyltransferase domain containing 7 (MBOAT7) rs8736 metabolic-dysfunction-associated fatty liver disease (MAFLD)-risk
Ziyan Pan +4 more
doaj +1 more source
Eicosanoids in the Innate Immune Response: TLR and Non-TLR Routes
Mediators of Inflammation, 2010 The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-derived dendritic cells since it ...
Yolanda Alvarez +8 more
openaire +4 more sources