Results 71 to 80 of about 97,388 (162)

Exosomes: Potential Therapies for Disease via Regulating TLRs

, 2020
Exosomes are small membrane vesicles that retain various substances such as proteins, nucleic acids, and small RNAs. Exosomes play crucial roles in many physiological and pathological processes, including innate immunity.
Hong-Yan Guo, Ming-Shu Wang, An-Chun Cheng, Ren-Yong Jia, Zhong-Qiong Yin   +4 more
core   +1 more source

Toll-like receptors and integrins crosstalk

Frontiers in Immunology
Immune system recognizes invading microbes at both pathogen and antigen levels. Toll-like receptors (TLRs) play a key role in the first-line defense against pathogens. Major functions of TLRs include cytokine and chemokine production.
Fahd Alhamdan, Fahd Alhamdan, Fahd Alhamdan, Ganchimeg Bayarsaikhan, Ganchimeg Bayarsaikhan, Ganchimeg Bayarsaikhan, Koichi Yuki, Koichi Yuki, Koichi Yuki   +8 more
doaj   +1 more source

Prophylactic Use of Chloroquine May Impair Innate Immune System Response against SARS-Cov-2 [PDF]

Pharmaceutical Sciences, 2020
Hamid Soraya
doaj   +1 more source

Toll-like receptors of deuterostome invertebrates

Frontiers in Immunology, 2012
Defensive systems against pathogens are responsible not only for survival or lifetime of an individual but also for the evolution of a species. Innate immunity is expected to be more important for invertebrates than mammals, given that adaptive immunity ...
Honoo eSatake, Toshio eSekiguchi
doaj   +1 more source

Human TLRs and IL-1Rs in Host Defense: Natural Insights from Evolutionary, Epidemiological, and Clinical Genetics

, 2011
Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) have TIR intracellular domains that engage two main signaling pathways, via the TIR-containing adaptors MyD88 (which is not used by TLR3) and TRIF (which is used only by TLR3 and TLR4 ...
Jean-Laurent Casanova, Lluis Quintana-Murci, Laurent Abel   +2 more
core   +1 more source

Release from UNC93B1 reinforces the compartmentalized activation of select TLRs [PDF]

, 2019
Nucleic acid-sensing Toll-like receptors (TLRs) are subject to complex regulation to facilitate the recognition of microbial DNA and RNA while limiting the recognition of an organism’s own nucleic acids1.
Van Dis, Erik, Majer, O., Gregory M. Barton, Woo, Brian J, Brian J. Woo, Kreuk, L., Bo Liu, Woo, B., Lieselotte S. M. Kreuk, Olivia Majer, Majer, Olivia, Liu, Bo, Liu, B., Barton, Gregory M, Erik Van Dis, Dis, E., Barton, G., Kreuk, Lieselotte SM   +17 more
core   +1 more source

TLRs Go Linear – On the Ubiquitin Edge [PDF]

, 2017
Toll-like receptors (TLRs) are crucial in protecting the host from pathogens. However, their exact role in disease remains incompletely understood.
Walczak, H, Zinngrebe, J
core   +1 more source

Expression and distribution of Toll-like receptors 11–13 in the brain during murine neurocysticercosis

Journal of Neuroinflammation, 2008
The functions of Toll-like receptors (TLRs) 11–13 in central nervous system (CNS) infections are currently unknown. Using a murine model of neurocysticercosis, we investigated the expression and distribution of TLRs 11–13 by using both gene specific real-
Teale Judy M, Gundra Uma, Mishra Bibhuti B   +2 more
doaj   +1 more source

mRNA and protein expression levels of TLRs (TLR1–10) in human liver cancer cell line BEL-7402.

, 2012
Semi-quantitative RT-PCR result of TLRs in BEL-7402. GAPDH mRNA was used as the control(A). Real-time RT-PCR of TLRs in BEL-7402. The expression of TLR7 was normalized to 1.0 as its level was lowest among all TLRs(B). TLR protein expression levels in BEL-
Ming Xu (151206), Yonghua Zhou (151227), Bing Cai (151199), Zhiqin Qiu (151213), Xiaofeng Han (151229), Yuzheng Huang (151191), Yonghui Tao (151217), Jie Wang (16762), Qi Gao (133189), Jing Yang (13969), Yongliang Xu (151223), Ying Zhang (40767)   +11 more
core   +1 more source

Toll-like receptors in breast cancer immunity and immunotherapy

Frontiers in Immunology
Toll-like receptors (TLRs) are a key family of pattern recognition receptors (PRRs) in the innate immune system. The activation of TLRs will not only prevent pathogen infection but also respond to damage-induced danger signaling.
Joseph Zhou, Lin Zhang, Siyao Liu, David DeRubeis, Dekai Zhang   +4 more
doaj   +1 more source