Results 61 to 70 of about 148,110 (341)

Messenger RNA expression of toll-like receptors (TLR2, TLR4, and TLR9) in HIV-1 infected patients with and without tuberculosis co-infection

International Journal of Mycobacteriology, 2022
Background: Gene expression levels of TLRs (TLR2, TLR4 and TLR9) are directly involved in the virus recognition and initiation of innate immune responses, therefore, the effect of HIV infection on TLRs gene expression was investigated in functional ...
Gaurav Kaushik, Richa Vashishtha
doaj   +1 more source

TLRs alignments and trees [PDF]

, 2017
Raw sequence alignments and trees used to perform selection analyses in TLRs (Table 1, Table 2 and Figure ...
Edson Ishengoma (3755254), Morris Agaba (373418)   +1 more
core   +1 more source

Toll-Like Receptors Serve as Biomarkers for Early Diagnosis and Prognosis Assessment of Kidney Renal Clear Cell Carcinoma by Influencing the Immune Microenvironment: Comprehensive Bioinformatics Analysis Combined With Experimental Validation

Frontiers in Molecular Biosciences, 2022
Background: Toll-like receptors (TLRs) are important initiators of innate and acquired immune responses. However, its role in kidney renal clear cell carcinoma (KIRC) remains unclear.Methods: TLRs and their relationships with KIRC were studied in detail ...
Xiong Zou, Xiong Zou, Xiong Zou, Xiong Zou, Bingqian Guo, Bingqian Guo, Bingqian Guo, Bingqian Guo, Qiang Ling, Qiang Ling, Qiang Ling, Qiang Ling, Zengnan Mo, Zengnan Mo, Zengnan Mo, Zengnan Mo, Zengnan Mo   +16 more
doaj   +1 more source

Crosstalk between Peroxisome Proliferator-Activated Receptors andToll-Like Receptors: A Systematic Review [PDF]

Advanced Pharmaceutical Bulletin, 2019
As one of the four major families of pattern recognition receptors (PRRs), toll like receptors (TLRs)are crucial and important components of the innate immune system. Peroxisome proliferatoractivatedreceptors (PPARs) with three isoforms are transcription
Nasim Dana, Golnaz Vaseghi, Shaghayegh Haghjooy-Javanmard   +2 more
doaj   +1 more source

TLRs as miRNA Receptors [PDF]

Cancer Research, 2012
Abstract MicroRNAs (miRNA) are small noncoding RNAs with gene regulatory functions. Their expression is frequently dysregulated in almost all human tumors and they can be found circulating within exosomes secreted by cancer cells. In addition to being promising cancer biomarkers with diagnostic, prognostic, and theranostic implications ...
openaire   +2 more sources

Two Modes of Ligand Recognition by TLRs [PDF]

, 2007
Toll-like receptors (TLRs) are membrane-bound sensors that detect and respond to microbial infection. Two studies in Cell, one in this issue, reveal how TLRs recognize their ligands. Kim et al.
Brodsky, Igor, Medzhitov, Ruslan
core   +1 more source

Toll-Like Receptors in Malaria: Gatekeepers of Innate Immunity and Pathogenesis

Journal of Pure and Applied Microbiology
Plasmodium parasites, transmitted to human blood via the bite of the Anopheles mosquito, cause malaria, an acute and severe disease that can potentially be fatal.
Khalid Abosalif, Muhammad Atif, Hasnain Farooq, Abualgasim Elgaili Abdalla, Albadawi Talha, Marwa Abdalla, Nada Amien, Bi Bi Zainab Mazhari, Hasan Ejaz   +8 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Selection test at nine koala TLRs. [PDF]

, 2015
*Significant purifying selection p ≤0.05Selection test at nine koala TLRs.
Katherine Belov (14402), Greta J. Frankham (709518), Adam Polkinghorne (81145), Rebecca N. Johnson (709519), Peter Timms (206543), Yuanyuan Cheng (159805), Denis O’Meally (709520), Jian Cui (182110)   +7 more
core   +1 more source

Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective

Diabetes, Metabolic Syndrome and Obesity, 2020
Zhaoping Wang,1 Xiaolin Ni,1,2 Li Zhang,1 Liang Sun,1 Xiaoquan Zhu,1 Qi Zhou,1 Ze Yang,1 Huiping Yuan1 1The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Graduate School of
Wang Z, Ni X, Zhang L, Sun L, Zhu X, Zhou Q, Yang Z, Yuan H   +7 more
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