Results 1 to 10 of about 21,015 (212)

Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention [PDF]

Animal Models and Experimental Medicine
Background This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous ...
Zhongping Xie, Hong Zou, Lijing Gong, Minghui Lin, Caihua Huang   +4 more
doaj   +2 more sources

Lactobacilli and Bifidobacterium as anti- atherosclerotic agents [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Atherosclerosis is the thickening or hardening of the arteries which is caused by a buildup of atheromatous plaque in the inner lining of an artery. Hypercholesterolemia, inflammation, oxidative stress, and trimethylamine N-oxide (TMAO) are important ...
Milad Abdi, Hadi Esmaeili Gouvarchin Ghaleh, Reza Ranjbar   +2 more
doaj   +1 more source

Sex-specific differences in trimethylamine N-oxide (TMAO) concentrations before and after cardiac rehabilitation in acute myocardial infarction patients

EXCLI Journal : Experimental and Clinical Sciences, 2022
Trimethylamine N-oxide (TMAO) is a biomarker of cardiovascular risk and may enhance the progression of atherosclerosis. The aim of the study was to determine whether there are sex-specific differences in TMAO concentrations before and after cardiac ...
Andreas Baranyi, Andreas Meinitzer, Dirk von Lewinski, Hans-Bernd Rothenhäusler, Omid Amouzadeh-Ghadikolai, Hanns Harpf, Leonhard Harpf, Heimo Traninger, Ronald Hödl, Birgit M. Harb, Barbara Obermayer-Pietsch, Melanie Schweinzer, Celine K. Braun, Dietmar Enko   +13 more
doaj   +1 more source

Hawthorn fruit extract reduced trimethylamine-N-oxide (TMAO)-exacerbated atherogenesis in mice via anti-inflammation and anti-oxidation

Nutrition & Metabolism, 2021
Background Trimethylamine-N-oxide (TMAO) is an independent risk factor for atherosclerosis. Consumption of hawthorn fruit is believed to be cardio-protective, yet whether it is able to suppress the TMAO-induced atherosclerosis remains unexplored.
Zouyan He, Erika Kwek, Wangjun Hao, Hanyue Zhu, Jianhui Liu, Ka Ying Ma, Zhen-Yu Chen   +6 more
doaj   +1 more source

TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats

eLife, 2020
Trimethylamine-oxide (TMAO) is present in seafood which is considered to be beneficial for health. Deep-water animals accumulate TMAO to protect proteins, such as lactate dehydrogenase (LDH), against hydrostatic pressure stress (HPS).
Marta Gawrys-Kopczynska, Marek Konop, Klaudia Maksymiuk, Katarzyna Kraszewska, Ladislav Derzsi, Krzysztof Sozanski, Robert Holyst, Marta Pilz, Emilia Samborowska, Leszek Dobrowolski, Kinga Jaworska, Izabella Mogilnicka, Marcin Ufnal   +12 more
doaj   +1 more source

Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways

JCI Insight, 2023
We determined whether gut microbiota-produced trimethylamine (TMA) is oxidized into trimethylamine N-oxide (TMAO) in nonliver tissues and whether TMAO promotes inflammation via trained immunity (TI).
Fatma Saaoud, Lu Liu, Keman Xu, Ramon Cueto, Ying Shao, Yifan Lu, Yu Sun, Nathaniel W. Snyder, Sheng Wu, Ling Yang, Yan Zhou, David L. Williams, Chuanfu Li, Laisel Martinez, Roberto I. Vazquez-Padron, Huaqing Zhao, Xiaohua Jiang, Hong Wang, Xiaofeng Yang   +18 more
doaj   +1 more source

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Redox Biology, 2021
Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity and atherosclerosis.
Shan Jiang, Yongjie Shui, Yu Cui, Chun Tang, Xiaohua Wang, Xingyu Qiu, Weipeng Hu, Lingyan Fei, Yun Li, Suping Zhang, Liang Zhao, Nan Xu, Fang Dong, Xiaoqiu Ren, Ruisheng Liu, Pontus B. Persson, Andreas Patzak, En Yin Lai, Qichun Wei, Zhihua Zheng   +19 more
doaj   +1 more source

Nonlethal Inhibition of Gut Microbial Trimethylamine N‐oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N‐oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine.
Chelsea L. Organ, Zhen Li, Thomas E. Sharp, David J. Polhemus, Nilaksh Gupta, Traci T. Goodchild, W. H. Wilson Tang, Stanley L. Hazen, David J. Lefer   +8 more
doaj   +1 more source

Finding small molecular compounds to decrease trimethylamine oxide levels in atherosclerosis by virtual screening

Open Chemistry, 2023
The intestinal microbial metabolite trimethylamine oxide (TMAO) affects the formation and development of atherosclerosis (AS). The design and development of an effective targeted drug to reduce serum TMAO levels may provide new avenues for inhibiting AS ...
Luo Jiaxin, Zhang Aoqi, Yao Yuan, Yuan Jun   +3 more
doaj   +1 more source

Trimethylamine N-Oxide (TMAO) Inducing Endothelial Injury: UPLC-MS/MS-Based Quantification and the Activation of Cathepsin B-Mediated NLRP3 Inflammasome

Molecules, 2023
TMAO is a new risk biomarker for cardiovascular disease. With trimethylammonium as its main chemical skeleton, TMAO is structurally similar to many endogenous metabolites, such as acetylcholine, carnitine, phosphorylcholine, etc. The mechanism of TMAO on
Dongyu Lei, Wenbo Yu, Yi Liu, Yujie Jiang, Xiaohui Li, Jing Lv, Ying Li   +6 more
doaj   +1 more source