Results 121 to 130 of about 25,778 (287)

Measuring the stability of partly folded proteins using TMAO [PDF]

Protein Science, 2003
AbstractStandard methods for measuring free energy of protein unfolding by chemical denaturation require complete folding at low concentrations of denaturant so that a native baseline can be observed. Alternatively, proteins that are completely unfolded in the absence of denaturant can be folded by addition of the osmolyte trimethylamine N‐oxide (TMAO),
Cecilia C, Mello, Doug, Barrick
openaire   +2 more sources

Satellite remote sensing data can be used to model marine microbial metabolite turnover [PDF]

, 2014
Sampling ecosystems, even at a local scale, at the temporal and spatial resolution necessary to capture natural variability in microbial communities are prohibitively expensive.
A Ditchfield, A Toseland, A-B Martin-Cuadrado, AJ Southward, Anton F Post, B Pfeil, BB Jørgensen, Dawn Field, EL Barrett, FO Glöckner, J Ladau, J Yu, JA Fuhrman, JA Gilbert, JA Gilbert, JA Gilbert, JA Gilbert, Jack A Gilbert, JG Caporaso, KA Kilpatrick, KJ Popendorf, KL Carder, M Hügler, M Schmidt, MGI Langille, MJ Follows, N Fierer, N Fierer, NA Kamennaya, NA Kamennaya, Nicole Scott, NM Scott, OU Mason, PE Larsen, PE Larsen, Peter E Larsen, RD Graetz, RJW Brewin, RK Thauer, Rob Knight, S Archer, SC Doney, SM Gibbons, TJ Smyth, VA Smith, W Paul Bissett, X Wang, Yuki Hamada   +47 more
core   +3 more sources

TMAO Destabilizes RNA Secondary Structure via Direct Hydrogen Bond Interactions [PDF]

, 2022
Samuel S. Cho, Adam T. Green, Changbong Hyeon, D. Thirumalai   +3 more
openalex   +1 more source

Trimethylamine N‐oxide is elevated in postmenopausal women relative to age‐matched men and premenopausal women among individuals with obesity

Experimental Physiology, EarlyView.
Abstract Trimethylamine N‐oxide (TMAO) is linked to arterial stiffness and atherosclerosis. Cardiovascular disease (CVD) risk increases following menopause in women. Whether menopause influences plasma TMAO metabolism to mediate CVD risk is unknown.
Daniel J. Battillo, Steven K. Malin
wiley   +1 more source

Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications

MedComm, Volume 7, Issue 2, February 2026.
The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin, Minying Xiong, Aimin Jiang, Li Chen, Lihaoyun Huang, Kailai Li, Hank Z. H. Wong, Jian Zhang, Zaoqu Liu, Quan Cheng, Bufu Tang, Pengpeng Zhang, Peng Luo   +12 more
wiley   +1 more source

Gut Microbiota-Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target

Frontiers in Pharmacology, 2019
Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in developed countries, and atherosclerosis (AS) is the common pathological basis of many cardiovascular diseases (CVDs) such as coronary heart disease (CHD).
Shengjie Yang, Xinye Li, Fan Yang, Ran Zhao, Xiandu Pan, Jiaqi Liang, Li Tian, Xiaoya Li, Longtao Liu, Yanwei Xing, Min Wu   +10 more
semanticscholar   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Identification of YdhV as the first molybdoenzyme binding a Bis-Mo-MPT cofactor in escherichia coli [PDF]

, 2019
The oxidoreductase YdhV in Escherichia coli has been predicted to belong to the family of molybdenum/tungsten cofactor (Moco/Wco)-containing enzymes. In this study, we characterized the YdhV protein in detail, which shares amino acid sequence homology ...
Dau, Holger, Duffus, Benjamin R., Haumann, Michael, Leimkühler, Silke, Mebs, Stefan, Reschke, Stefan, Schrapers, Peer, Teutloff, Christian   +7 more
core   +1 more source

Syntheses and Structures of Water‐Soluble Model Complexes Related to the Active Site of Molybdenum and Tungsten‐Dependent Oxidoreductases

Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 1, January 6, 2026.
Complex salts with potassium counter cations and bisdithiolene oxido molybdate or tungstate anions are water tolerant and soluble in purely aqueous medium. Four different synthetic routes to water‐soluble complexes of the type K2[MOx(dt)2] (M = Mo, W; dt = ene‐1,2‐dithiolate, x = 1, 2) applicable to different ligand precursors are presented.
Sebastian Pätsch, Anna‐Lena Land, Caroline Hannah Paul, Benedict Josua Elvers, Marlen Redies, Christian Fischer, Carola Schulzke   +6 more
wiley   +1 more source

Role of gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health [PDF]

, 2018
Purpose of this Review: This review assesses the latest evidence linking short-chain fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and presents the latest evidence on possible biological mechanisms.
Chambers, Edward S., Frost, Gary, Morrison, Douglas J., Preston, Tom   +3 more
core   +1 more source