Results 131 to 140 of about 16,933 (236)

Network and Experimental Pharmacology on Mechanism of Yixintai Regulates the TMAO/PKC/NF-κB Signaling Pathway in Treating Heart Failure

Drug Design, Development and Therapy
Ziyan Wang,1,2,* Chengxin Liu,1,2,* Jiaming Wei,2,3 Hui Yuan,1,2 Min Shi,2,3 Fei Zhang,2,3 Qinghua Zeng,2,3 Aisi Huang,2,3 Lixin Du,4 Ya Li,4 Zhihua Guo2,3 1First Clinical College of Chinese Medicine, Hunan University of Chinese Medicine ...
Wang Z, Liu C, Wei J, Yuan H, Shi M, Zhang F, Zeng Q, Huang A, Du L, Li Y, Guo Z   +10 more
doaj  

Study on the Effect of Trimethylamine Oxide on Recurrent Cerebral Infarction of Minor Ischaemic Stroke Rats

Cerebrovascular Diseases Extra
Introduction: This study investigates the impact of trimethylamine oxide (TMAO) on recurrent cerebral infarction in minor ischaemic stroke (MIS). Methods: A rat model was used, with dietary choline levels adjusted to vary TMAO levels. TMAO was
Chen Chen, Ziwei Hou, Hong Liu, Jintao Wang, Jianyong Guo, Ting Yang, Min Wang, Ling Ding   +7 more
doaj   +1 more source

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1717-1737, October 2026.
ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman, Claudio Pedrick, Cara A. Kreck, Ricardo L. Mancera   +3 more
wiley   +1 more source

Comparison of Different TMAO Force Fields and Their Impact on the Folding Equilibrium of a Hydrophobic Polymer

, 2016
Trimethylamine N-oxide (TMAO) is a protective osmolyte able to preserve protein folded states in the presence of denaturants like urea and under extreme thermodynamic conditions of high pressure and temperature. The current understanding posits that TMAO
Philipp Rötzscher (2939235), Francisco Rodríguez-Ropero (1784269), Roetzscher, Philipp, Rodriguez-Ropero, Francisco, Vegt, Nico F. A. van der, Nico F. A. van der Vegt (1235007)   +5 more
core   +1 more source

Identification of trimethylamine N-oxide (TMAO)-producer phenotype is interesting, but is it helpful?

, 2020
We read with great interest the paper by Wu et al 1 reporting on the development of a carnitine challenge test to facilitate the identification of trimethylamine N-oxide (TMAO)-producer phenotype and host-diet-gut dysbiosis.
Arduini, Arduino, Bonomini, Mario, Zammit, Victor A.   +2 more
core   +1 more source

Potential Roles of Escherichia coli in IgA Nephropathy: Evidence, Mechanistic Hypotheses and Microbiota‐Targeted Strategies

Microbial Biotechnology, Volume 19, Issue 10, October 2026.
Schematic diagram of the core pathogenic pathway by which E. coli drives IgAN.E. coli expansion in IgAN is driven by host, environmental and ecological factors, and promotes disease progression via two core pathways: LPS‐induced immune activation and pyroptosis, and metabolite‐mediated remote regulation, leading to Gd‐IgA1 overproduction, mesangial ...
Yuxin Liu, Xiaoxuan Ning, Yichen Liu, Zixian Yu, Jie Liu, Xiaoqin Xu, Jin Zhao, Shiren Sun   +7 more
wiley   +1 more source

The Role of torS and torT Transcription in Driving a Bet‐Hedging Strategy for Trimethylamine N‐Oxide Reductase Expression in Escherichia coli

Molecular Microbiology, Volume 126, Issue 4, Page 379-395, October 2026.
Low basal activity of divergent promoters driving transcription of the trimethylamine N‐oxide (TMAO) sensor TorT and kinase TorS is integral to an O2‐regulated bet‐hedging strategy for continued E. coli growth upon the onset of anaerobiosis. This, along with repression by IscR, promotes noise in the TorS to TorT ratio, which is critical for adaptation ...
Erin L. Mettert, Jeffrey N. Carey, Wilma Ross, Mark Goulian, Patricia J. Kiley   +4 more
wiley   +1 more source

Soolestiku mikroobide vahendusel moodustuv metaboliit trimetülamiin N-oksiid (TMAO) ja selle seosed tervisenäitajatega Soome populatsioonis [PDF]

, 2018
Viimastel aastatel on üha rohkem tähelepanu pälvinud bakterite vahendatud ainevahetuse käigus moodustuv metaboliit TMAO, mida peetakse võimalikuks biomarkeriks südameveresoonkonna, ainevahetus- ja neeruhaiguste tuvastamisel ning potenstiaalseks ...
Koppel, Johana
core  

TMAO and TMA in plasma and urine after PC loadings.

, 2017
TMAO and TMA in plasma and urine after PC loadings.
Gert Fricker (308126), Wolfgang Stremmel (46931), Sven F. Garbade (3700849), Jürgen G. Okun (3700846), Claus-Dieter Langhans (3700843), Vera Schuhmann (3700834), Frank Kratzer (3700837), Kathrin V. Schmidt (3700840)   +7 more
core   +1 more source

Research progress on the association between TMAO and vascular calcification in patients with chronic kidney disease

Vascular calcification (VC) is a common complication in patients with chronic kidney disease (CKD) and a major risk factor for increased cardiovascular mortality in patients with CKD.
Yuxin Zhang, Liangying Huang, Santao Ou
core   +1 more source