Results 141 to 150 of about 16,933 (236)

Characterization of E. coli apo-TMAO reductase reconstituted with FdsC or FdhD.

, 2018
For the reconstitution of enzyme activity, 50 μM of each FdhD, FdsC or their variants was incubated with apo-TMAO reductase (8 μM) in a total volume of 8 ml. After 7 hours, the samples were concentrated to 500 μl before size exclusion chromatography. The
Angelika Lehmann (5982788), Nadine Schwanhold (5982785), Chantal Iobbi-Nivol (4810782), Silke Leimkühler (126058)   +3 more
core   +1 more source

TMAO and diabetes: from the gut feeling to the heart of the problem

Nutrition & Diabetes
Abstract Elevated plasma levels of trimethylamine N-oxide (TMAO)—a compound derived from diet and the gut microbiome—have been widely studied for their association with diabetes risk and their potential role in disease pathophysiology and complications.
Kinga Jaworska, Monika Kuś, Marcin Ufnal   +2 more
openaire   +3 more sources

Role of Trimethylamine N‐Oxide in Assessing Plaque Instability of the Culprit Lesion in Chinese Patients With ST‐Elevation Myocardial Infarction: Insights From a 7‐Year Long‐Term Follow‐Up Study

Clinical and Translational Science
This study investigated the relationship between trimethylamine N‐oxide (TMAO) levels and plaque instability in Chinese patients with ST‐elevation myocardial infarction (STEMI) using optical coherence tomography (OCT), with a 7 ‐year follow‐up.
Lili Xiu, Peng Zhao, Xia Gu, Bo Yu
doaj   +1 more source

Chronic Treatment of TMAO Undermines Mouse Cardiac Structure and Function in a Sex-specific Manner

, 2023
Cardiovascular disease (CVD) is a major cause of mortality and morbidity worldwide, often with heart failure as the terminal stage. Clinical studies have associated elevated levels of trimethylamine N-oxide (TMAO), a gut-derived metabolite, with adverse ...
Ding, Hanzhang
core  

Role of Trimethylamine N-Oxide in Heart Failure

Reviews in Cardiovascular Medicine
Heart failure (HF) is a clinical syndrome characterizing by typical physical signs and symptomatology resulting from reduced cardiac output and/or intracardiac pressure at rest or under stress due to structural and/or functional abnormalities of the ...
Lele Jing, Honghong Zhang, Qiannan Xiang, Huilin Hu, Changlin Zhai, Suining Xu, Hongen Tian   +6 more
doaj   +1 more source

Urea and TMAO on Lipid Bilayers [PDF]

Biophysical Journal, 2018
Sergio S. Funari, Bernstorff Sigrid, Joana Valerio   +2 more
openaire   +1 more source

Trimethylamine-N-oxide and 5-year mortality: the role of gut microbiota-generated metabolite from the CORE-Thailand cohort

Scientific Reports
The gut microbiota metabolite trimethylamine-N-oxide (TMAO)—derived from dietary phosphatidylcholine—is mechanistically linked to cardiovascular disease (CVD) and increased cardiovascular risk.
Vichai Senthong, Songsak Kiatchoosakun, Chaiyasith Wongvipaporn, Jutarop Phetcharaburanin, Piyamitr Sritara, Arintaya Phrommintikul, CORE Investigators   +6 more
doaj   +1 more source

Trimethylamine N-oxide, S-equol, and indoxyl sulfate inflammatory microbiota players in ocular Behçet’s disease

Türk Biyokimya Dergisi
The aims of the study were to assess the levels of serum TMAO, S-equol, and indoxyl sulfate in subjects with ocular active Behçet’s disease (OABD) and ocular inactive Behçet’s disease (OIBD).
Arslan Sermal, Kaya Mehmet Kaan, Aydin Suna, Aydin Suleyman   +3 more
doaj   +1 more source

Implication of Trimethylamine N-Oxide (TMAO) in disease: Potential biomarker or new therapeutic target [PDF]

, 2018
Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several factors including diet, gut microbial flora, drug administration and liver flavin
Martinez, J.A. (José Alfredo), Ramirez, M.J. (María Javier), Solas, M. (Maite), Janeiro-Arenas, M.H. (Manuel Humberto), Milagro-Yoldi, F.I. (Fermín Ignacio)   +4 more
core  

TMAO [PDF]

, 2019
openaire   +1 more source