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Time Exposure and Fat Mass Reduction Drive Trimethylamine N-Oxide Modulation During a Very-Low-Energy Ketogenic Therapy (VLEKT) in Women with Obesity. [PDF]
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Protein Stability in TMAO and Mixed Urea–TMAO Solutions
The Journal of Physical Chemistry B, 2020Osmolytes are essential for cellular function under ubiquitous osmotic stress. Trimethylamine N-oxide (TMAO) is one such osmolyte that has gained remarkable attention due to its protein-protective ability against urea. This Review aims at providing a detailed account of recent theoretical and experimental developments in characterizing the structural ...
Pritam Ganguly +4 more
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TMAO to the rescue of pathogenic protein variants
Biochimica et Biophysica Acta (BBA) - General Subjects, 2022Trimethylamine N-oxide (TMAO) is a chemical chaperone found in various organisms including humans. Various studies unveiled that it is an excellent protein-stabilizing agent, and induces folding of unstructured proteins. It is also well established that it can counteract the deleterious effects of urea, salt, and hydrostatic pressure on macromolecular ...
Kritika, Kumari +4 more
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Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2002
Trimethylamine oxide (TMAO) acts as an osmolyte in a wide variety of marine organisms, but little is known about the mechanisms by which it accumulates in certain tissues. To determine whether a TMAO-specific transporter occurs in Nature, we examined a bacterium Aminobacter aminovorans that is known to be able to subsist on methylamine as the sole ...
James A, Raymond, George E, Plopper
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Trimethylamine oxide (TMAO) acts as an osmolyte in a wide variety of marine organisms, but little is known about the mechanisms by which it accumulates in certain tissues. To determine whether a TMAO-specific transporter occurs in Nature, we examined a bacterium Aminobacter aminovorans that is known to be able to subsist on methylamine as the sole ...
James A, Raymond, George E, Plopper
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Influence of TMAO and Pressure on the Folding Equilibrium of TrpCage
The Journal of Physical Chemistry B, 2022Trimethylamine-N-oxide (TMAO) is an osmolyte known for its ability to counteract the pressure denaturation of proteins. Computational studies addressing the molecular mechanisms of TMAO's osmolyte action have however focused exclusively on its protein-stabilizing properties at ambient pressure, neglecting the changes that may occur under high-pressure ...
Angelina Folberth +1 more
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TMAO: A small molecule of great expectations
Nutrition, 2015Trimethylamine N-oxide (TMAO) is a small organic compound whose concentration in blood increases after ingesting dietary l-carnitine and phosphatidylcholine. Recent clinical studies show a positive correlation between elevated plasma levels of TMAO and an increased risk for major adverse cardiovascular events defined as death, myocardial infarction, or
Marcin Ufnal +2 more
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