Results 111 to 120 of about 16,933 (236)

Effects of Weight Loss Interventions on Gut Microbiota‐Derived Metabolites Linked to Cardiometabolic Health: A Systematic Review and Meta‐Analysis

Obesity Reviews, Volume 27, Issue 11, November 2026.
ABSTRACT Background Gut microbiota‐derived metabolites are emerging as potential mediators between obesity and cardiometabolic conditions. While weight loss interventions modify microbiota composition, their effects on systemic microbial metabolites remain unclear.
Fernando Q. Iorra, Leonardo André Swarowsky Loebens, Andrea Auler, Eduarda Caroline Tasso Nascimento, Beatriz D. Schaan, Patrícia Martins Bock   +5 more
wiley   +1 more source

Effects of osmolytes on protein-solvent interactions in crowded environment: Analyzing the effect of TMAO on proteins in crowded solutions

, 2015
We analyzed the effect of a natural osmolyte, trimethylamine N-oxide (TMAO), on structural properties and conformational stabilities of several proteins under macromolecular crowding conditions by a set of biophysical techniques. We also used the solvent
Leonid Breydo, Ferreira, Luisa, Sales, Amanda E., Olga Fedotoff, Kroeck, Kyle G., Vladimir N. Uversky, Permyakov, Sergei E., Zaslavsky, Boris Y., Sergei E. Permyakov, Uversky, Vladimir N., Kyle G. Kroeck, Breydo, Leonid, Fedotoff, Olga, Marina P. Shevelyova, Permyakov, Eugene A., Boris Y. Zaslavsky, Eugene A. Permyakov, Shevelyova, Marina P., Amanda E. Sales, Luisa Ferreira   +19 more
core   +1 more source

One Hundred Years of Sulfido Ligand in the Molybdenum Cofactor: New Perspectives

ChemBioChem, Volume 27, Issue 19, 14 October 2026.
The terminal sulfido ligand in mononuclear molybdoenzymes has been appreciated for almost 125 years, with the characterization of Schardinger's enzyme in cow's milk, now known to be xanthine oxidase, that was isolated in 1902 in Vienna, Austria. The ligand is found in molybdoenzymes identified across all kingdoms of life.
Silke Leimkühler, Benjamin R. Duffus, Carola Schulzke   +2 more
wiley   +1 more source

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, Volume 13, Issue 55, 5 October 2026.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 1964-1981, October 2026.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

The gut microbiota metabolite trimethylamine N-oxide promotes cardiac hypertrophy by activating the autophagic degradation of SERCA2a

Communications Biology
Trimethylamine oxide (TMAO) is a newly found intestinal microbiota metabolite. Here, we aimed to explore the effects of TMAO on calcium homeostasis and its implication in cardiac hypertrophy, especially focusing on the regulatory mechanism of TMAO on the
Dongyu Lei, Yi Liu, Yuan Liu, Yujie Jiang, Yuyan Lei, Feilong Zhao, Wenqun Li, Zhonghua Ouyang, Lulu Chen, Siyuan Tang, Dongsheng Ouyang, Xiaohui Li, Ying Li   +12 more
doaj   +1 more source

Mechanism of TMAO-mediated NLRP3 inflammasome in the pathogenesis of large artery atherosclerosis in the head and neck

徐州医科大学学报
Objective To screen for specific metabolites in patients with large artery atherosclerosis (LAA) in the head and neck and to verify whether these metabolic markers can upregulate the NLR family pyrin domain containing protein 3 (NLRP3) inflammasome to ...
CHEN Zhiren, HUANG Zehua, YANG Meifang, ZHOU Zixuan, CHEN Weiwei, WANG Peian   +5 more
doaj   +1 more source

Effect of Rifaximin and a Multi-Strain Probiotic on the Intestinal Microbiome and Cardiovascular Risk Indicators in Patients with Coronary Heart Disease

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2019
Aim. To assess the effect of rifaximin and a multi-strain probiotic on the intestinal microbiome and the indicators of cardiovascular risk in patients with coronary heart disease (CHD).Materials and methods.
E. A. Kashukh, E. A. Poluektova, A. V. Kudryavtseva, G. S. Krasnov, V. I. Kazey, P. D. Sobolev, P. V. Gremyakova, V. T. Ivashkin   +7 more
doaj   +1 more source

Axial Connectivity of the Lung Microbiome: A Review of Interorgan Crosstalk

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
The human microbiome mediates immune homeostasis and metabolic signaling across organs. Beyond the gut‐lung axis, crosstalk between the lung and other organ systems is less recognized. This review assesses the axial connectivity of the lung microbiome across the gut, brain, skin, heart, kidney, and liver.
Mathangi Palanivel, Jayanth Kumar Narayana, Sanjay H. Chotirmall   +2 more
wiley   +1 more source

Trimethylamine oxide supplementation differentially regulates fat deposition in liver, longissimus dorsi muscle and adipose tissue of growing-finishing pigs

Animal Nutrition
Trimethylamine oxide (TMAO) is a microbiota-derived metabolite, and numerous studies have shown that it could regulate fat metabolism in humans and mice. However, few studies have focused on the effects of TMAO on fat deposition in growing-finishing pigs.
Andong Zha, Wanquan Li, Jing Wang, Ping Bai, Ming Qi, Peng Liao, Bie Tan, Yulong Yin   +7 more
doaj   +1 more source