Results 101 to 110 of about 16,933 (236)

Interaction of Zwitterionic Osmolyte Trimethylamine Noxide (TMAO) with Molecular Hydrophobes: An Interplay of Hydrophobic and Electrostatic Interactions

, 2021
Interaction of trimethylamine N-oxide (TMAO) with charged/uncharged moieties of proteins and lipids is an important elementary step toward the multifaceted biofunctions of TMAO. Using minimum area Raman difference spectroscopy (MA-RDS) of aqueous TMAO (1.
Animesh Patra, Subhadip Roy (2920017), Dipak K. Palit (1484845), Jahur Alam Mondal (9338117), Animesh Patra (1852306), Dipak K. Palit, Subhadip Roy, Jahur Alam Mondal   +7 more
core   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Metabolic pattern across energy imbalance: An exploratory metabolomics study of female body weight extremes including anorexia nervosa and athletes

Experimental Physiology, EarlyView.
Abstract In anorexia nervosa (AN), prolonged metabolic adaptation to severe energy deficiency can impair treatment efficacy. Similarly, low energy availability poses a recognized risk to athletes, potentially compromising health and performance. This cross‐sectional study aimed to characterize the plasma metabolic pattern of females with varying ...
Sonja Lackner, Olli Kärkkäinen, Sabrina Mörkl, Wolfram Müller, Alfred Fürhapter‐Rieger, Kati Hanhineva, Sandra Johanna Holasek   +6 more
wiley   +1 more source

Stabilizing effect of TMAO on globular PNIPAM states: preferential attraction induces preferential hydration

, 2016
We study the effect of the organic co-solute trimethylamine N-oxide (TMAO) on the volume phase transition of microgel particles made from poly(N-isopropylacrylamide) (PNIPAM) using dynamic light scattering (DLS) and all-atom molecular dynamics (MD ...
Martin A. Schroer, Smiatek, Jens, Fischer, Birgit, Julian Michalowsky, Schroer, Martin, Jens Smiatek, Michalowsky, Julian, Gerhard Grübel, Gruebel, Gerhard, Birgit Fischer   +9 more
core   +1 more source

Establishment of a mouse model of TMAO‐induced cardiac injury and application of MICT intervention

Animal Models and Experimental Medicine
Background This study aims to explore the establishment of an animal model of cardiac injury induced by trimethylamine‐N‐oxide (TMAO), a metabolite secreted by gut microorganisms, and to investigate its application in moderate‐intensity continuous ...
Zhongping Xie, Hong Zou, Lijing Gong, Minghui Lin, Caihua Huang   +4 more
doaj   +1 more source

Trimethylamine-N-Oxide (TMAO)-Induced Impairment of Cardiomyocyte Function and the Protective Role of Urolithin B-Glucuronide [PDF]

, 2018
One of the most recently proposed candidates as a potential trigger for cardiovascular diseases is trimethylamine-N-oxide (TMAO). Possible direct effects of TMAO on myocardial tissue, independent of vascular damage, have been only partially explored so ...
Daniele Del Rio, Alan Crozier, Angela Falco, Federico Quaini, Donatella Stilli, Leonardo Bocchi, Monia Savi, Letizia Bresciani, Pedro Mena, Furio Brighenti   +9 more
core   +1 more source

Reconstitution of E. coli apo-TMAO reductase using FdsC or FdhD as bis-MGD source.

, 2018
50 μM of each purified chaperone variant was incubated with apo-TMAO reductase (8 μM) to reconstitute enzyme activity. After 2 hours TMAO reductase activity was measured under anaerobic conditions following the oxidation of reduced benzyl viologen at 600
Angelika Lehmann (5982788), Nadine Schwanhold (5982785), Chantal Iobbi-Nivol (4810782), Silke Leimkühler (126058)   +3 more
core   +1 more source

Mechanism of Prominent Trimethylamine Oxide (TMAO) Accumulation in Hemodialysis Patients. [PDF]

, 2015
Large size, protein binding and intracellular sequestration are well known to limit dialytic removal of compounds. In studying the normal renal and dialytic handling of trimethylamine oxide (TMAO), a molecule associated with cardiovascular disease in the
Timothy W Meyer, Xin Hai, Peter DeOreo, Veeda Landeras (835688), Mirela A Dobre, Thomas H. Hostetter (734396), Timothy W. Meyer (734395), Peter DeOreo (835690), Thomas H Hostetter, Xin Hai (835687), Veeda Landeras, Mirela A. Dobre (835689), Hostetter Thomas H., DeOreo Peter, Meyer Timothy W., Hai Xin, Landeras Veeda, Dobre Mirela A.   +17 more
core   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Dietary bioactive ingredients to modulate the gut microbiota-derived metabolite TMAO. New opportunities for functional food development

, 2020
There is a growing body of clinical evidence that supports a strong association between elevated circulating trimethylamine N-oxide (TMAO) levels with increased risk of developing adverse cardiovascular outcomes such as atherosclerosis and thrombosis ...
García-Cañas, Virginia, Simó, Carolina   +1 more
core   +1 more source