Results 91 to 100 of about 16,933 (236)

Involvement of trimethylamine N-oxide in major depressive disorder via astrocytic d-Serine dysregulation

Neurotherapeutics
Trimethylamine N-oxide (TMAO), a co-metabolite of the gut microbiota and host, has been implicated in the pathogenesis of various neuropsychiatric disorders. However, its role in major depressive disorder (MDD) remains poorly understood.
Liwang Lin, Longyu Li, Shiao Ren, Liping Liu, Ying Liu, Wenlei Zhang, Zengliang Gao, Xiaoting Ni, Haoxuan Li, Xinsheng Duan, Sijing Tao, Tianyu Zhao, Xin Hai   +12 more
doaj   +1 more source

Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress

Frontiers in Molecular Neuroscience, 2020
Dysbiosis of gut microbiota is strongly associated with metabolic diseases including diabetes mellitus, obesity, and cardiovascular disease. Recent studies indicate that Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite is implicated in ...
Manoj Govindarajulu, Manoj Govindarajulu, Priyanka D. Pinky, Priyanka D. Pinky, Ian Steinke, Jenna Bloemer, Jenna Bloemer, Sindhu Ramesh, Sindhu Ramesh, Thiruchelvan Kariharan, Robert T. Rella, Subhrajit Bhattacharya, Subhrajit Bhattacharya, Muralikrishnan Dhanasekaran, Muralikrishnan Dhanasekaran, Vishnu Suppiramaniam, Vishnu Suppiramaniam, Rajesh H. Amin, Rajesh H. Amin   +18 more
doaj   +1 more source

Association Characteristics and Potential Mechanisms of Aging, Gut Microbiota, and Hearing Loss

Integrative Zoology, EarlyView.
The study found that aging leads to unchanged gut microbiota alpha diversity but an increase in Bacteroidetes and a decrease in Firmicutes at the phylum level, with specific genera, species, and functional pathways co‐associated with aging and hearing loss. Through constructing a microbe‐metabolite network, it revealed the mechanism by which protective
Cheng Cheng, Lu Wang, Runhan Li, Wenkai Lai, Chongkui Sun, Jianguo Cui, Bicheng Zhu, Jiang Zhang   +7 more
wiley   +1 more source

Trimethylamine-N-oxide is an independent risk factor for hospitalization events in patients receiving maintenance hemodialysis

Renal Failure, 2020
Background Hospitalization is a significant outcome measurement for maintenance hemodialysis pantients. Trimethylamine-N-oxide (TMAO), created by gut microflora from dietary l-carnitine and choline, cleared by the kidney, has been implicated in the ...
Yin Zheng, Zihui Tang, Li You, Yuanhao Wu, Junfeng Liu, Jun Xue   +5 more
doaj   +1 more source

Alamandine/MrgD pathway modulates gut–bone marrow axis in ageing

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ageing is associated with colon epithelial barrier disruption and up‐regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut–
Kishore Chittimalli, Henryata E. Rozario, Victor Martinez, Zachary L. McAdams, Stephen A. Adkins, Aaron C. Ericsson, Yagna P. R. Jarajapu   +6 more
wiley   +1 more source

TMAO and Intermittent Exercise: Raw Data

Raw data for circulating TMAO and choline values analysed by LC-MS/MS following either an intermittent exercise or time-matched resting control period.Article abstract:Trimethylamine N-oxide (TMAO) is a gut bacteria-dependent metabolite associated with ...
Andrea Salzano (3663148), Marilyn Ong Li Yin (10878381), Christopher Green (1250637), Katie Rider (17945346), Samantha Rowland (4742598), Harry Sutcliffe (17945349), Liam Heaney (5153435)   +6 more
core   +1 more source

Adaptation to extreme environments: A review of Antarctic fish physiology

Journal of Fish Biology, EarlyView.
Abstract Having evolved in the chronically cold and thermally stable waters of the Southern Ocean (SO) for millions of years, Antarctic fish possess a suite of physiological specializations that enable them to survive at temperatures near the freezing point of seawater. Adaptations include the evolution of antifreeze proteins, modifications of membrane
Seungyeon Lee, Sachithra Amarin Hettiarachchi, Il‐Chan Kim, Jae‐Seong Lee, Thomas Desvignes, Julia M. York, Laura Ghigliotti, Jilda Alicia Caccavo, Jin‐Hyoung Kim   +8 more
wiley   +1 more source

Subjects specific dynamics of TMAO and creatine.

, 2014
Dynamics of TMAO (panel A) and creatine (panel B) concentrations (expressed in arbitrary units) for four different individuals. While creatine shows similar scattered dynamic for all subjects, TMAO dynamics can be rather different between individuals.
Jildau Bouwman (186744), Paul Verbruggen (517391), Leonardo Tenori (629909), Claudio Luchinat (629910), Edoardo Saccenti (217343), Marieke E. Timmerman (411298), Age K. Smilde (149094), Jan van der Greef (39107)   +7 more
core   +1 more source

Hydration in aqueous osmolyte solutions: the case of TMAO and urea

Physical Chemistry Chemical Physics, 2020
X-ray Raman scattering spectroscopy and first principles simulations reveal details of the hydration and hydrogen-bond topology of trimethylamine N-oxide (TMAO) and urea in aqueous solutions.
Christoph J. Sahle, Martin A. Schroer, Johannes Niskanen, Mirko Elbers, Cy M. Jeffries, Christian Sternemann   +5 more
openaire   +3 more sources

Four Haylages, One Metabonome: Defining Diet Driven Metabolic Shifts in Ponies

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Haylage is widely fed to all categories of stabled horses across Europe and New Zealand. Haylage can vary from high energy nutrient dense forage to low energy highly fibrous fodder, yet little is known about the impact different haylages have on metabolism in horses.
Meriel Moore‐Colyer, Pat Harris, Simon Daniels   +2 more
wiley   +1 more source