Results 11 to 20 of about 21,015 (212)
Background Diet Influences TMAO Concentrations Associated with Red Meat Intake without Influencing Apparent Hepatic TMAO-Related Activity in a Porcine Model [PDF]
Metabolites, 2020 Red meat has been associated with an increased cardiovascular disease (CVD) risk, possibly through gut microbial-derived trimethylamine-N-oxide (TMAO).
Rebekka Thøgersen +7 more
doaj +5 more sources
TMAO: a potential mediator of clopidogrel resistance [PDF]
Scientific Reports, 2021 Trimethylamine-N-oxide (TMAO) can activate platelets and increase thrombosis risk in clinical and experimental models. Meanwhile, the patients with coronary artery disease have higher serum TMAO level.
Ruisong Ma +5 more
doaj +3 more sources
Hydrophobic association and solvation of neopentane in urea, TMAO and urea–TMAO solutions [PDF]
Physical Chemistry Chemical Physics, 2021 Hydrophobic associations in pure water, urea solution, TMAO solution and urea-TMAO solution were studied using molecular dynamics simulations.
Timir Hajari +2 more
openaire +2 more sources
Blood, 2020 In this issue of Blood, Wu and colleagues report that trimethylamine N-oxide (TMAO), an intestinal microbiome-dependent metabolite, worsens graft-versus-host disease (GVHD). They further found that TMAO induces M1 polarization of bone marrow–derived macrophages via the nucleotide-binding oligomerization domain–like receptor protein 3 (NLRP3). TMAO is
Eiko, Hayase, Robert R, Jenq
openaire +2 more sources
TMAO-Protein Preferential Interaction Profile Determines TMAO’s Conditional In Vivo Compatibility [PDF]
Biophysical Journal, 2016 Trimethylamine N-oxide (TMAO) exemplifies how Nature uses the solute effect as a simple chemical strategy to cope with hydrodynamic pressure or urea stress to maintain proteostasis. It is a gut-microbe-generated metabolite that strongly promotes the development of atherosclerosis. It remains unclear how TMAO exerts its effects.
Jiang, Hong, Shangqin, Xiong
openaire +2 more sources
TMAO: Protecting proteins from feeling the heat [PDF]
Biophysical Journal, 2020 Osmolytes are ubiquitous in the cell and play an important role in controlling protein stability under stress. The natural osmolyte trimethylamine N-oxide (TMAO) is used by marine animals to counteract the effect of pressure denaturation at large depths.
Mayank Boob +3 more
openaire +2 more sources
TMAO: how gut microbiota contributes to heart failure [PDF]
Translational Research, 2021 An increasing amount of evidence reveals that the gut microbiota is involved in the pathogenesis and progression of various cardiovascular diseases. In patients with heart failure (HF), splanchnic hypoperfusion causes ischemia and intestinal edema, allowing bacterial translocation and bacterial metabolites to enter the blood circulation via an impaired
Yixin, Zhang +3 more
openaire +2 more sources
Trimethylamine N-oxide (TMAO) in human health
EXCLI journal, 2021 Due to numerous links between trimethylamine-N-oxide (TMAO) and various disorders and diseases, this topic is very popular and is often taken up by researchers. TMAO is a low molecular weight compound that belongs to the class of amine oxides. It is formed by the process of oxidation of trimethylamine (TMA) by the hepatic flavin monooxygenases (FMO1 ...
Gatarek, Paulina +1 more
openaire +2 more sources
Entropic Stabilization of Proteins by TMAO [PDF]
The Journal of Physical Chemistry B, 2011 To understand the mechanism of trimethylamine N-oxide (TMAO) induced stabilization of folded protein states, we systematically investigated the action of TMAO on several model dipeptides (Leucine, L2, Serine, S2, Glutamine, Q2, Lysine, K2, and Glycine, G2) in order to elucidate the effect of residue-specific TMAO interactions on small fragments of ...
Cho, Samuel S. +3 more
openaire +3 more sources
Aerobic TMAO respiration in Escherichia coli [PDF]
Molecular Microbiology, 2007 SummaryIn the absence of oxygen, Escherichia coli can use alternative exogenous electron acceptors, including trimethylamine oxide (TMAO), to generate energy. In this study, we showed that in contrast to the other anaerobic respiratory systems, the TMAO reductase (Tor) system was expressed during both aerobiosis and anaerobiosis.
Ansaldi, Mireille +4 more
openaire +3 more sources