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Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease?
International Journal of Molecular Sciences, 2023 Trimethylamine-N-oxide (TMAO) is the main diet-induced metabolite produced by the gut microbiota, and it is mainly eliminated through renal excretion. TMAO has been correlated with an increased risk of atherosclerotic cardiovascular disease (ASCVD) and ...
Marina Canyelles +5 more
semanticscholar +1 more source
Science immunology, 2022 The composition of the gut microbiome can control innate and adaptive immunity and has emerged as a key regulator of tumor growth, especially in the context of immune checkpoint blockade (ICB) therapy.
Gauri Mirji +13 more
semanticscholar +1 more source
Pharmaceuticals, 2023 Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely associated with diseases such as atherosclerosis and hypertension, and ...
Meyammai Shanmugham +2 more
semanticscholar +1 more source
TMAO-Protein Preferential Interaction Profile Determines TMAO’s Conditional In Vivo Compatibility [PDF]
Biophysical Journal, 2016 Trimethylamine N-oxide (TMAO) exemplifies how Nature uses the solute effect as a simple chemical strategy to cope with hydrodynamic pressure or urea stress to maintain proteostasis. It is a gut-microbe-generated metabolite that strongly promotes the development of atherosclerosis. It remains unclear how TMAO exerts its effects.
Jiang, Hong, Shangqin, Xiong
openaire +2 more sources
TMAO: Protecting Proteins from Feeling the Heat [PDF]
Biophysical Journal, 2020 Osmolytes are ubiquitous in the cell and play an important role in controlling protein stability under stress. The natural osmolyte trimethylamine N-oxide (TMAO) is used by marine animals to counteract the effect of pressure denaturation at large depths.
Mayank Boob +3 more
openalex +3 more sources
American Journal of Clinical Nutrition, 2022 Background Trimethylamine N-oxide (TMAO), a metabolite from red meat and fish consumption, plays a role in promoting cardiovascular events. However, data regarding TMAO and its impact on clinical outcomes are inconclusive, possibly due to its ...
Lu Dai +16 more
openalex +3 more sources
Signal Transduction and Targeted Therapy, 2022 Trimethylamine-N-oxide (TMAO) derived from the gut microbiota is an atherogenic metabolite. This study investigates whether or not berberine (BBR) could reduce TMAO production in the gut microbiota and treat atherosclerosis.
Shu-Rong Ma +15 more
semanticscholar +1 more source
Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite
International Journal of Molecular Sciences, 2023 Endothelial function is essential in the maintenance of systemic homeostasis, whose modulation strictly depends on the proper activity of tissue-specific angiocrine factors on the physiopathological mechanisms acting at both single and multi-organ levels.
G. Querio +4 more
semanticscholar +1 more source
Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases
Biomedicines, 2023 Trimethylamine N-oxide (TMAO) is a metabolite produced by the gut microbiota and has been mainly associated with an increased incidence of cardiovascular diseases (CVDs) in humans. There are factors that affect one’s TMAO level, such as diet, drugs, age,
semanticscholar +1 more source
Entropic Stabilization of Proteins by TMAO [PDF]
The Journal of Physical Chemistry B, 2011 To understand the mechanism of trimethylamine N-oxide (TMAO) induced stabilization of folded protein states, we systematically investigated the action of TMAO on several model dipeptides (Leucine, L2, Serine, S2, Glutamine, Q2, Lysine, K2, and Glycine, G2) in order to elucidate the effect of residue-specific TMAO interactions on small fragments of ...
Samuel S. Cho +3 more
openalex +5 more sources