Results 41 to 50 of about 25,778 (287)

Trimethylamine N-oxide in atrial fibrillation progression

International Journal of Cardiology: Heart & Vasculature, 2020
The human gut microbiome and its metabolite Trimethylamine N-oxide (TMAO) are sensitive to the human diet and are involved in the complex pathomechanisms that underpin diabetes, obesity, and cardiovascular diseases.
Petra Büttner, Jürgen G. Okun, Jana Hauke, Erik Holzwirth, Danilo Obradovic, Gerhard Hindricks, Holger Thiele, Jelena Kornej   +7 more
doaj   +1 more source

Finding small molecular compounds to decrease trimethylamine oxide levels in atherosclerosis by virtual screening

Open Chemistry, 2023
The intestinal microbial metabolite trimethylamine oxide (TMAO) affects the formation and development of atherosclerosis (AS). The design and development of an effective targeted drug to reduce serum TMAO levels may provide new avenues for inhibiting AS ...
Luo Jiaxin, Zhang Aoqi, Yao Yuan, Yuan Jun   +3 more
doaj   +1 more source

Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding [PDF]

, 2010
Transmissible spongiform encephalopathies, or prion diseases, are caused by misfolding and aggregation of the prion protein PrP. These diseases can be hereditary in humans and four of the many disease-associated missense mutants of PrP are in the ...
Daggett, Valerie, van der Kamp, Marc W
core   +2 more sources

The Gut Microbial-Derived Metabolite Trimethylamine N-Oxide and Atrial Fibrillation: Relationships, Mechanisms, and Therapeutic Strategies

Clinical Interventions in Aging, 2021
Rui Huang,1,* Li Yan,2,* Yuhua Lei1 1Cardiovascular Disease Center, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi Prefecture, 445000, Hubei Province, People’s Republic of China ...
Huang R, Yan L, Lei Y
doaj  

Relationship between Plasma Trimethylamine N-Oxide Levels and Renal Dysfunction in Patients with Hypertension

Kidney & Blood Pressure Research, 2021
Introduction: Trimethylamine N-oxide (TMAO) is a metabolite produced by gut bacteria. Although increased TMAO levels have been linked to hypertension (HTN) and chronic kidney disease (CKD) with poor prognosis, no clinical studies have directly addressed ...
Jia Zhou, Dingkun Wang, Bingong Li, Xuelian Li, Xingjun Lai, Shufang Lei, Na Li, Xuting Zhang   +7 more
doaj   +1 more source

Associations of trimethylamine N-oxide (TMAO) and its precursors with childhood obesity: a case-control study. [PDF]

BMC Endocr Disord
Li Y, Wang X, Chen M, Xiao M, Ma L, Zhou T, Wang M, Song Q.   +7 more
europepmc   +3 more sources

Gut-Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet [PDF]

, 2017
Gut microbiota is emerging as a novel risk factor for atherothrombosis, but the predictive role of gut-derived lipopolysaccharide (LPS) is unknown. We analyzed (1) the association between LPS and major adverse cardiovascular events (MACE) in atrial ...
Cammisotto, Vittoria, Carnevale, Roberto, Menichelli, Danilo, Nocella, Cristina, Novo, Marta, Pastori, Daniele, Pignatelli, Pasquale, Santulli, Maria, Violi, Francesco   +8 more
core   +1 more source

Trimethylamine N-Oxide and Related Metabolites in the Serum and Risk of Type 2 Diabetes in the Chinese Population: A Case-Control Study

Diabetes, Metabolic Syndrome and Obesity, 2023
Shenghong Qi,1,2 Lan Liu,1,2 Shulan He,1,2 Liqun Wang,1,2 Jiangping Li,1,2 Xian Sun1,2 1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2The Key Laboratory of Environmental Factors and ...
Qi S, Liu L, He S, Wang L, Li J, Sun X
doaj  

Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice

Scientific Reports, 2021
Patients with chronic kidney disease (CKD) have elevated circulating levels of trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes and associated with cardiovascular diseases.
Wenchao Zhang, Aika Miikeda, J. Zuckerman, Xun Jia, S. Charugundla, Zhiqiang Zhou, K. Kaczor‐Urbanowicz, C. Magyar, Fang Guo, Zeneng Wang, M. Pellegrini, S. Hazen, S. Nicholas, A. Lusis, D. Shih   +14 more
semanticscholar   +1 more source

Untargeted lipidomic features associated with colorectal cancer in a prospective cohort. [PDF]

, 2018
BackgroundEpidemiologists are beginning to employ metabolomics and lipidomics with archived blood from incident cases and controls to discover causes of cancer.
Cai, Xiaoming, Dudoit, Sandrine, Edmands, William MB, Grigoryan, Hasmik, Gunter, Marc J, Naccarati, Alessio, Perttula, Kelsi, Petrick, Lauren, Polidoro, Silvia, Rappaport, Stephen M, Schiffman, Courtney, Vineis, Paolo   +11 more
core   +3 more sources