Results 51 to 60 of about 21,015 (212)

TMAO-Activated Hepatocyte-Derived Exosomes Impair Angiogenesis via Repressing CXCR4

Frontiers in Cell and Developmental Biology, 2022
Objective: Trimethylamine-N-oxide (TMAO) was found to play crucial roles in vascular endothelial function. However, the exact molecular mechanisms are not yet entirely clear. Recently, we found that exosomes (Exos) isolated from TMAO-treated hepatocytes (
Xiang Liu, Xiang Liu, Xiang Liu, Yijia Shao, Yijia Shao, Jiazichao Tu, Jiazichao Tu, Jiazichao Tu, Jiapan Sun, Bing Dong, Bing Dong, Zhichao Wang, Zhichao Wang, Jianrong Zhou, Jianrong Zhou, Jianrong Zhou, Long Chen, Jun Tao, Jun Tao, Jimei Chen, Jimei Chen, Jimei Chen   +21 more
doaj   +1 more source

A Multi-Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice. [PDF]

Aging Cell
A gut‐derived metabolic signature drives systemic aging phenotypes. Integrated multi‐omics profiling of young versus aged mice identifies a conserved aging signature characterized by the depletion of protective lysophosphatidylcholines (LPC 22:0) and the concurrent accumulation of pro‐oxidative microbial catabolites (TMAO, IAA).
Sajid S, Huang J, Kong S, Lai C, Tan Z, Shao Y, Guo L.   +6 more
europepmc   +2 more sources

TMAO is Associated with Mortality: Impact of Modestly Impaired Renal Function [PDF]

Scientific Reports, 2017
AbstractTrimethylamine-N-Oxide (TMAO) is a microbiome-related metabolite that is cleared by the kidney and linked to renal function. We explored the relationship between TMAO and all-cause mortality, and determined whether this association was modified by renal function.
Eke G. Gruppen, Erwin Garcia, Margery A. Connelly, Elias J. Jeyarajah, James D. Otvos, Stephan J. L. Bakker, Robin P. F. Dullaart   +6 more
openaire   +3 more sources

Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N-Oxide [PDF]

Journal of Stroke, 2019
Trimethylamine N-oxide (TMAO) is produced when trimethylamine, a waste product of gut microbes, is converted via hepatic flavin monooxygenases. As TMAO is a potential causative factor in various cardiovascular diseases (CVDs) considerable research ...
Hyo Suk Nam
doaj   +1 more source

Adaptation of anaerobic cultures of Escherichia coliK-12 in response to environmental trimethylamine-N-oxide [PDF]

, 2015
Systematic analyses of transcriptional and metabolic changes occurring when Escherichia coliK-12 switches from fermentative growth to anaerobic respiratory growth with trimethylamine-N-oxide (TMAO) as the terminal electron acceptor revealed: (i) the ...
Alvarez, Ansaldi, Ansaldi, Asif, Baraquet, Barbieri, Barrett, Bekker, Bock, Datsenko, Evans, Fu, Futai, Gennis, Georgellis, Georgellis, Graef, Guest, Gutheil, Heldal, Hempfling, Herring, Hitchcock, Holm, Keseler, Koeth, McCrindle, Moore, Méjean, Nash, Neidhardt, Partridge, Partridge, Rodriguez, Rolfe, Rolfe, Sanguinetti, Simon, Simon, Thauer, Trotter, Volentini, Wang, Wissenbach   +43 more
core   +2 more sources

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Serum Intestinal Metabolites are Raised in Patients with Psoriasis and Metabolic Syndrome

Clinical, Cosmetic and Investigational Dermatology, 2022
Liyun Sun,1,* Xinwei Guo,2,* Yeping Qin,3 Ping Li,4 Chunxia Yu,2 Xuesong Gao,2 Xinran Xie,4 Xuying Xu5 1Dermatology Department, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, People’s Republic of ...
Sun L, Guo X, Qin Y, Li P, Yu C, Gao X, Xie X, Xu X   +7 more
doaj  

Elevation of Trimethylamine-N-Oxide in Chronic Kidney Disease: Contribution of Decreased Glomerular Filtration Rate

Toxins, 2019
Gut microbiota-dependent Trimethylamine-N-oxide (TMAO) has been reported to be strongly linked to renal function and to increased cardiovascular events in the general population and in Chronic Kidney Disease (CKD) patients.
Caroline C. Pelletier, Mikael Croyal, Lavinia Ene, Audrey Aguesse, Stephanie Billon-Crossouard, Michel Krempf, Sandrine Lemoine, Fitsum Guebre-Egziabher, Laurent Juillard, Christophe O. Soulage   +9 more
doaj   +1 more source

Relation between TMAOase activity and content of formaldehyde in fillet minces and bellyflap minces from gadoid fishes [PDF]

, 1997
Minced fish is a significant component of a number of frozen fishery products like fish fingers, cakes and patties. Predominately minced fish is produced from gadoid species (Alaska pollack, cod, saithe, hake and others) possessing the enzyme ...
Gonzales-Sotelo, C., Havemeister, W., Jessen, F., Jorgensen, B., Nielsen, M.K., Rehbein, Hartmut, Schubring, Reinhard   +6 more
core  

Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure (from BIOSTAT-CHF) [PDF]

, 2018
Aims: Association of elevated circulating levels of trimethylamine N-oxide (TMAO) with adverse outcomes in patients with heart failure (HF) has been described.
Anker, Stefan D., Chan, Daniel C. S., Cleland, John G. F., Dickstein, Kenneth, Filippatos, Gerasimos S., Hillege, Hans L., Jones, Donald J. l., Lang, Chim C., Metra, Marco, Ng, Leong Loke, Ponikowski, Peter, Samani, Nilesh J., Suzuki, Toru, van Veldhuisen, Dirk Jan, Voors, Adriaan A., Yazaki, Yoshiyuki, Zannad, Faiez, Zwinderman, Aeilko H.   +17 more
core   +4 more sources