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[Severe degenerative changes of the temporomandibular joint associated with diffuse sclerosing osteomyelitis]. [PDF]

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Dewenter I, Otto S, Hildebrandt T, Smolka W, Reichel CA, Obermeier KT.   +5 more
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Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA

Journal of Dental Research, 2023
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with the cessation of matrix anabolism and aggravation of inflammation, which results in severe pain and impaired joint function. However, the mechanisms are not well understood.
Xiao Cen
exaly   +3 more sources

Chronic Pain Causes Peripheral and Central Responses in MIA-Induced TMJOA Rats

Cellular and Molecular Neurobiology, 2021
Chronic pain is the predominant symptom that drives temporomandibular joint osteoarthritis (TMJOA) patients to seek medical care; however, currently used treatment modalities remain less effective. This study aimed to investigate chronic pain and the peripheral and central responses in monoiodoacetate (MIA)-induced TMJOA rats.
Jin Ke, Xing Long
exaly   +3 more sources

ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling

Journal of Dental Research, 2022
Temporomandibular joint osteoarthritis (TMJOA) is a common degenerative joint disease without effective intervention strategies. Previous research implied that alpha-kinase 1 (ALPK1) is involved in the inflammatory responses of gout, a chronic arthritis. Herein, we found the main distribution of ALPK1 in a proliferative layer of condylar cartilage and
Yping Feng
exaly   +3 more sources

Inhibiting Hh Signaling in Gli1⁺ Osteogenic Progenitors Alleviates TMJOA

Journal of Dental Research, 2022
The increased prevalence of temporomandibular joint osteoarthritis (TMJOA) in children and adolescents has drawn considerable attention as it may interfere with mandibular condyle growth, resulting in dento-maxillofacial deformities. However, treatments for osteoarthritis have been ineffective at restoring the damaged bone and cartilage structures due
J, Lei, S, Chen, J, Jing, T, Guo, J, Feng, T V, Ho, Y, Chai   +6 more
openaire   +2 more sources

Loss of RAP2A Aggravates Cartilage Degradation in TMJOA via YAP Signaling

Journal of Dental Research, 2022
Abnormal stress loading has been considered a major contributor to the initiation of temporomandibular joint osteoarthritis (TMJOA), but studies to date have not identified a functional molecule that transforms physical stress into biological or biochemical signaling in chondrocytes in response to excessive mechanical stress.
H. Qi, Y. Zhang, L. Xu, X. Zheng, Y. Li, Q. Wei, Y. Li, Z. Zhao, J. Fang   +8 more
openaire   +2 more sources

TLR4 contributes to the damage of cartilage and subchondral bone in discectomy‐induced TMJOA mice [PDF]

Journal of Cellular and Molecular Medicine, 2020
AbstractThe abundance of inflammatory mediators in injured joint indicates innate immune reactions activated during temporomandibular joint osteoarthritis (TMJOA) progression. Toll‐like receptor 4 (TLR4) can mediate innate immune reaction. Herein, we aimed to investigate the expression profile and effect of TLR4 in the cartilage and subchondral bone of
Xing Long
exaly   +3 more sources

Bafilomycin A1 mitigates subchondral bone degeneration and pain in TMJOA rats

International Immunopharmacology
Pain and disability are primary concerns for temporomandibular joint osteoarthritis (TMJOA) patients, and the efficacy of current treatments remains controversial. Overactive osteoclasts are associated with subchondral bone degeneration and pain in OA. The vacuolar H+-ATPase (V-ATPase) is crucial for differentiation and function in osteoclasts, but its
Xing Long
exaly   +3 more sources

Piezo1 mediates the degradation of cartilage extracellular matrix in malocclusion‐induced TMJOA

Oral Diseases, 2023
AbstractObjectivesTo evaluate the role of Piezo1 in the malocclusion‐induced osteoarthritic cartilage of the temporomandibular joint.MethodsA temporomandibular joint osteoarthritis model was established using a unilateral anterior crossbite in vivo, and cartilage degeneration and Piezo1 expression were observed by histological and immunohistochemical ...
Xu Feng, Siwen Li, Shuangshuang Wang, Yuan Meng, Shize Zheng, Cangwei Liu, Bei Chang, Ce Shi, Hongchen Sun   +8 more
openaire   +2 more sources

Inflammation Triggers Chondrocyte Ferroptosis in TMJOA via HIF-1α/TFRC

Journal of Dental Research
Inflammation and loss of articular cartilage are considered the major cause of temporomandibular joint osteoarthritis (TMJOA), a painful condition of the temporomandibular joint (TMJ). To determine the cause of TMJ osteoarthritis in these patients, synovial fluid of TMJOA patients was compared prior to and after hyaluronic lavage, revealing ...
Thomas G H Diekwisch, Chang Liu
exaly   +3 more sources