Results 151 to 160 of about 771 (176)

Peroxisome Functional Inhibition Alleviates TMJOA Cartilage Degradation

Journal of Dental Research
Temporomandibular joint osteoarthritis (TMJOA) is a progressive and debilitating degenerative joint disorder characterized by cartilage degradation. Its pathogenesis remains poorly understood, and current treatment strategies are insufficient to restore normal joint structure.
Hexu Qi, Li Xiao, Yu Li
exaly   +2 more sources

Combination of hyperlipidemia and 17β‐Estradiol induces TMJOA‐like pathological changes in rats

Oral Diseases, 2022
Abstract Objective We explored whether hyperlipidemia or combination of hyperlipidemia and E2 could induce TMJOA. Materials and Methods Four groups of female rats were treated with normal diet, normal diet with E2 ...
Yan Zhao, Ye‐Hua Gan
openaire   +2 more sources

Melatonin Abates TMJOA Chronic Pain by MT₂R in Trigeminal Ganglion Neurons

Journal of Dental Research, 2021
Temporomandibular joint osteoarthritis (TMJOA) is one of the most common diseases causing chronic pain in the oral and maxillofacial region. So far, there are few ways to relieve the pain of TMJOA. Melatonin (MT) has a good analgesic effect in many diseases, including fibromyalgia, neuropathic pain, chronic headache, and burn pain, with very low acute
W, Liu, H, Jiang, X, Liu, S, Hu, H, Li, Y, Feng, J, Ke, X, Long   +7 more
openaire   +2 more sources

Disturbed Glycometabolism‐Induced Chondrocyte Apoptosis Contributes to TMJOA

Oral Diseases
ABSTRACT Objective Elucidate the mechanism underlying chondrocyte apoptosis induced by abnormal glycometabolism in the early stages of temporomandibular joint osteoarthritis (TMJOA) and identify potential therapeutic targets. Design
Yidan Zhang, Luxuan Cai, Shengjie Cui, Yanning Guo, Ning Hu, Yuan Zhang, Yehua Gan, Jieni Zhang, Xuedong Wang   +8 more
openaire   +1 more source

Toll‐like receptor 2 mediates the degeneration of cartilage in experimental inflammatory TMJOA

Oral Diseases, 2020
Abstract Objective Synovial inflammation and intra‐articular excessive pressure were accepted as two predominant etiologies for temporomandibular joint osteoarthritis (TMJOA). Toll‐like receptor 2 (TLR2) exerts roles both in certain inflammation‐ and pressure‐induced diseases.
Xin Liu, Yaping Feng, Wen Liu, Huimin Li, Zhihui Hu, Shiyu Hu, Jin Ke, Xing Long   +7 more
openaire   +1 more source

Ectodysplasin-A deficiency exacerbates TMJOA by upregulating ATF4/Ihh signaling in mice

Osteoarthritis and Cartilage
Ectodysplasin-A (EDA) has been reported to be involved in mouse condylar development, but the specific functions of EDA in maintaining homeostasis of the temporomandibular joint (TMJ) remain unclear. This study aims to explore the underlying roles and related mechanisms of EDA in temporomandibular joint osteoarthritis (TMJOA).The TMJOA mouse model was ...
Ludan Xing, Beizhan Jiang
exaly   +3 more sources

β-catenin Orchestrates Gli1+ Cell Fate in Condylar Development and TMJOA

Journal of Dental Research
The fibrocartilage stem cells (FCSCs) on the surface of the condyle play an essential role in cartilage homeostasis and regeneration. However, few well-defined stem cell markers have been identified for the analysis of FCSCs’ cell fate and regulation mechanism.
J. Wang, X. Dong, J. Lei, Y. Zhang, S. Chen, Y. He   +5 more
openaire   +2 more sources

TREM2 Activation Relieves TMJOA by Stabilizing the Synovial Barrier via Siglec1

Journal of Dental Research
Triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor that plays a vital role in innate immune responses. This study aims to investigate the effect of TREM2 on synovial barrier homeostasis and synovitis during temporomandibular joint osteoarthritis (TMJOA).
X. Liu, X. Luo, M. Xiao, J. Zhao, W. Fang, J. Ke, X. Long   +6 more
openaire   +2 more sources

sj-pdf-1-jdr-10.1177_00220345231198448 – Supplemental material for Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA

2023
Supplemental material, sj-pdf-1-jdr-10.1177_00220345231198448 for Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA by X. Pan, Z. Zhao, X. Huang and X.
Pan, X., Zhao, Z., Huang, X., Cen, X.
openaire   +1 more source

DDIT3 aggravates TMJOA cartilage degradation via Nrf2/HO-1/NLRP3-mediated autophagy

Osteoarthritis and Cartilage
DNA damage-inducible transcript 3 (DDIT3), as a downstream transcription factor of endoplasmic reticulum stress, is reported to regulate chondrogenic differentiation under physiological and pathological state. However, the specific involvement of DDIT3 in the degradation of condylar cartilage of temporomandibular joint osteoarthritis (TMJOA) is ...
Chang, Yang, Wei, Dong, Yan, Wang, Xiaofei, Dong, Xiaoxiao, Xu, Xijie, Yu, Jiawei, Wang   +6 more
exaly   +3 more sources