Results 51 to 60 of about 771 (176)

MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1. [PDF]

Arthritis Research & Therapy, 2019
Abstract Background: Due to the lack of research on the pathological mechanism of temporomandibular joint osteoarthritis (TMJOA), there are few effective treatment measures in the clinic. In recent years, microRNAs (miRs) have been demonstrated to play an important role in the pathogenesis of osteoarthritis (OA) by regulating a variety of ...
Shixing Ma, Aobo Zhang, Xiaole Li, Shizhou Zhang, Shaopeng Liu, Haoming Zhao, Shichao Wu, Lei Chen, Chuan Ma, Huaqiang Zhao   +9 more
openaire   +5 more sources

The Effect Of Mangiferin On Temporomandibular Joint Osteoarthritis

International Dental Journal
Aim or purpose: To investigate the role of mangiferin (MG) in the treatment of temporomandibular joint osteoarthritis (TMJOA) and clarify whether autophagy and SIRT1/mTOR pathway participate in MG treating TMJOA.
Xingtong Mu, Zhang Juan, Li Ziqi
doaj   +1 more source

Therapeutic applications of stem cells from human exfoliated deciduous teeth: a review [PDF]

, 2020
Dental stem cells have been found to have the ability to differentiate into nerve cells, adipose cells, chondrocytes, osteoblasts, myocytes, hepatocytes, and odontoblasts. They can be derived from permanent teeth or deciduous teeth. Stem cells from human
Baweja, Mani
core   +2 more sources

BMSC-Derived Small Extracellular Vesicles Induce Cartilage Reconstruction of Temporomandibular Joint Osteoarthritis via Autotaxin–YAP Signaling Axis

Frontiers in Cell and Developmental Biology, 2021
Background: Temporomandibular joint osteoarthritis (TMJOA) seriously affects the health of patients, and the current treatments are invasive and only used for advanced cases.
Yingnan Wang, Miaomiao Zhao, Wen Li, Yuzhi Yang, Zhenliang Zhang, Ruijie Ma, Mengjie Wu   +6 more
doaj   +1 more source

A functional genomics approach reveals suggestive quantitative trait loci associated with combined TLR4 and BCP crystal-induced inflammation and osteoarthritis [PDF]

, 2023
Objective: Basic calcium phosphate (BCP) crystals can activate the NLRP3 inflammasome and are potentially involved in the pathogenesis of osteoarthritis (OA).
, Boahen, Collins K., Boer, Cindy G., Crişan, Tania O., Dijkstra, Helga, Dos Santos, Jéssica C., Joosten, Leo A.B., Kischkel, Brenda, Klück, Viola, Kumar, Vinod, Leask, Megan P., Lemmers, Heidi, Matzaraki, Vasiliki, McCarthy, Geraldine M., Merriman, Tony R., Schraa, Kiki, van Meurs, Joyce B.J.   +16 more
core   +3 more sources

Sel1l preserves condylar cartilage matrix homeostasis by regulating PERK signaling

Interdisciplinary Medicine, EarlyView.
Our study revealed that the expression of Sel1l was downregulated in OA cartilage and that Sel1l deficiency induced cartilage catabolism. Mechanistically, Sel1l depletion aberrantly activated PERK signaling and resulted in ER stress. PERK inhibition rescued the phenotype of Sel1l‐deficient chondrocytes and alleviated TMJOA pathogenesis.
Xinqi Huang, Zinan Cen, Zhihe Zhao, Xiao Cen   +3 more
wiley   +1 more source

Metabolic profiling of synovial fluid in human temporomandibular joint osteoarthritis

Frontiers in Immunology
IntroductionTemporomandibular joint (TMJ) osteoarthritis (OA) is a common TMJ degenerative disease with an unclear mechanism. Synovial fluid (SF), an important component of TMJ, contains various proteins and metabolites that may directly contribute to OA.
Dahe Zhang, Dahe Zhang, Dahe Zhang, Dahe Zhang, Dahe Zhang, Dahe Zhang, Dahe Zhang, Yuxin Zhang, Yuxin Zhang, Yuxin Zhang, Yuxin Zhang, Yuxin Zhang, Yuxin Zhang, Yuxin Zhang, Simo Xia, Simo Xia, Simo Xia, Simo Xia, Simo Xia, Simo Xia, Simo Xia, Pei Shen, Pei Shen, Pei Shen, Pei Shen, Pei Shen, Pei Shen, Pei Shen, Chi Yang, Chi Yang, Chi Yang, Chi Yang, Chi Yang, Chi Yang, Chi Yang   +34 more
doaj   +1 more source

Positive experience with treatment is associated with better surgical outcome in trapeziometacarpal osteoarthritis [PDF]

, 2019
The aim of this study was to investigate the association between patients’ experiences with trapeziometacarpal arthroplasty and treatment outcomes in terms of patient-reported outcome measures, grip and pinch strength.
Feitz, W.F.J. (Wout), Hovius, S.E.R. (Steven), Oest, M.J.W. (Mark) van der, Poelstra, R. (Ralph), Porsius, J.T. (Jarry), Selles, R.W. (Ruud), Slijper, H.P. (Harm), Tsehaie, J. (Jonathan)   +7 more
core   +2 more sources

Circular RNAs and inflammation: epigenetic regulators with diagnostic role [PDF]

, 2023
Circular RNAs (circRNAs) are a group of transcripts generally known to be non-coding transcripts, but occasionally producing short peptides. Circ_Ttc3/miR-148a, circ_TLK1/miR-106a-5p, circ_VMA21/miR-9-3p, circ_0068,888/miR-21-5p, circ_VMA21/miR-199a-5p ...
Ghafouri-Fard, Soudeh, Hussen, Bashdar Mahmud, Pourmoshtagh, Hasan, Sabernia, Toofan, Shoorei, Hamed, Taheri, Mohammad   +5 more
core   +1 more source

Comparing Traditional Versus AI‐Assisted TMJ Disorder Management Approaches: A Systematic Review and Meta‐Analysis

Clinical and Experimental Dental Research, Volume 12, Issue 2, April 2026.
ABSTRACT Objective This systematic review and meta‐analysis compared traditional diagnostic approaches with artificial intelligence (AI)‐based techniques for temporomandibular joint disorders (TMDs) and evaluated their diagnostic accuracy. Methods Literature searches across PubMed‐MEDLINE, Scopus, Embase, Cochrane, and Google Scholar identified studies
Vini Mehta, Annie Vathani, Praveen Kumar Gonuguntla Kamma, Saurabh Chaturvedi, Ankita Mathur, Toufiq Noor   +5 more
wiley   +1 more source