Results 61 to 70 of about 583,823 (157)

Enhanced Immune Response Against the Thomsen-Friedenreich Tumor Antigen Using a Bivalent Entirely Carbohydrate Conjugate

Molecules, 2020
The Thomsen-Friedenreich (TF) antigen is a key target for the development of anticancer vaccines, and this ongoing challenge remains relevant due to the poor immunogenicity of the TF antigen.
Kristopher A. Kleski, Kevin R. Trabbic, Mengchao Shi, Jean-Paul Bourgault, Peter R. Andreana   +4 more
doaj   +1 more source

Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing. [PDF]

PLoS ONE, 2013
Membrane bound mucins are up-regulated and aberrantly glycosylated during malignant transformation in many cancer cells. This results in a negatively charged glycoprotein coat which may protect cancer cells from immune surveillance. However, only limited
Caroline B Madsen, Kirstine Lavrsen, Catharina Steentoft, Malene B Vester-Christensen, Henrik Clausen, Hans H Wandall, Anders Elm Pedersen   +6 more
doaj   +1 more source

Structural basis for the specificity of basic winged bean lectin for the Tn-antigen: A crystallographic, thermodynamic and modelling study

, 2005
The crystal structure of winged bean basic agglutinin in complex with GalNAc-α-O-Ser (Tn-antigen) has been elucidated at 2.35Å resolution in order to characterize the mode of binding of Tn-antigen with the lectin.
Samiksha Katiyar, Kaza Suguna, Surolia, Avadhesha, Kulkarni, Kiran A, Vijayan, Mamannamana, Kiran A. Kulkarni, Mamannamana Vijayan, Katiyar, Samiksha, Sharmistha Sinha, Kulkarni, Kiran A., Avadhesha Surolia, Sinha, Sharmistha, Suguna, Kaza   +12 more
core   +1 more source

Immature O-glycans recognized by the macrophage glycoreceptor CLEC10A (MGL) are induced by 4-hydroxy-tamoxifen, oxidative stress and DNA-damage in breast cancer cells

Cell Communication and Signaling, 2019
Background Ligands of the C-type lectin CLEC10A such as Tn and sialyl-Tn representing early intermediates of O-glycosylation are hallmarks of many human malignancies.
Anna-Katharina Kurze, Sophia Buhs, Dennis Eggert, Leticia Oliveira-Ferrer, Volkmar Müller, Axel Niendorf, Christoph Wagener, Peter Nollau   +7 more
doaj   +1 more source

The characterisation of the peanut agglutinin an evolved plant lectin, with improved specificity to the Thompson Freidenriech antigen [PDF]

, 2013
Includes abstract.Includes bibliographical references.Peanut agglutinin (PNA), a carbohydrate binding protein, is able to recognise and bind a number of distinct carbohydrate structures that have been implicated in a number of disease pathologies in ...
Lagardien, Zaida
core   +1 more source

A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer

iScience, 2020
Summary: The Tn antigen is a well-known tumor-associated carbohydrate determinant, often incorporated in glycopeptides to develop cancer vaccines. Herein, four copies of a conformationally constrained mimetic of the antigen TnThr (GalNAc-Thr) were ...
Amedeo Amedei, Fatemeh Asadzadeh, Francesco Papi, Maria Giuliana Vannucchi, Veronica Ferrucci, Iris A. Bermejo, Marco Fragai, Carolina Vieira De Almeida, Linda Cerofolini, Stefano Giuntini, Mauro Bombaci, Elisa Pesce, Elena Niccolai, Francesca Natali, Eleonora Guarini, Frank Gabel, Chiara Traini, Stefano Catarinicchia, Federica Ricci, Lorenzo Orzalesi, Francesco Berti, Francisco Corzana, Massimo Zollo, Renata Grifantini, Cristina Nativi   +24 more
doaj   +1 more source

Solid-phase synthesis of a pentavalent GalNAc-containing glycopeptide (Tn antigen) representing the nephropathy-associated IgA hinge region

, 2010
Incomplete or aberrant glycosylation leading to Tn antigen (GalNAca1-Ser/Thr) expression on human glycoproteins is strongly associated with human pathological conditions, including tumors, certain autoimmune diseases, such as the idiopathic IgA ...
Cummings, R.D., Bolscher, J.G.M., Jan G.M. Bolscher, Veerman, E.C.I., Tongzhong Ju, Joanna A.E. van Wijk, Kamran Nazmi, Richard D. Cummings, Ju, T., Judith Brevoord, Brevoord, J., Nazmi, K., van Wijk, J.A.E., Irma van Die, Enno C.I. Veerman, van Die, I.   +15 more
core   +1 more source

Carbohydrate antigens in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy

BMC Cancer, 2010
Background The goal of this prospective study was to determine (a) concentrations of the carbohydrate biomarkers Thomsen Friedenreich (TF) antigen and its precursor, Tn antigen, in nipple discharge (ND) collected from women requiring biopsy because of a ...
Vogeltanz-Holm Nancy, Holm Jeffrey E, Newton Jessica, Gui Gerald, Dickerson Marie, Deutscher Susan L, Kliethermes Beth, Hewett John E, Kumar Senthil R, Quinn Thomas P, Sauter Edward R   +10 more
doaj   +1 more source

Overexpression of Tn antigen induces chronic pancreatitis in mice

Scientific Reports
Altered O-glycosylation is a key contributor to various pathophysiological processes. Notably, the expression of the Tn antigen is primarily attributed to dysfunction of the chaperone Cosmc, while the overexpression of polypeptide N ...
Baris Mercanoglu, Nina Schraps, Anastasios D. Giannou, Elena Neuburg, Jan Kempski, Christoph Wagener, Nathaniel Melling, Maximilian Bockhorn, Thilo Hackert, Gerrit Wolters-Eisfeld   +9 more
doaj   +1 more source

Mannosylated T/Tn with Freund’s adjuvant induces cellular immunity

International Journal of Immunopathology and Pharmacology, 2018
Inducing cancer-specific cellular immune responses has become an attractive strategy in cancer treatment. In this study, we investigated the role of several adjuvants in eliciting T/Tn-specific cellular immunity and protection against T/Tn expressing ...
Hye-Youn Son, Vasso Apostolopoulos, Chul-Woo Kim   +2 more
doaj   +1 more source