Results 51 to 60 of about 583,823 (157)

Nuclear volume and expression of T-antigen, sialosyl-Tn-antigen, and Tn-antigen in carcinoma of the human bladder. Relation to tumor recurrence and progression [PDF]

open access: yesCancer, 1992
The T-antigen system and the mean nuclear volume have been proposed as risk variables in bladder tumors. This study includes 34 patients with initially noninvasive (Ta) transitional cell carcinomas who experienced different courses of disease. Tissue specimens of primary tumors were analyzed for the expression of T-antigen, Tn-antigen, and sialosyl-Tn ...
N C, Langkilde   +4 more
openaire   +2 more sources

Molecular Cloning, Carbohydrate Specificity and the Crystal Structure of Two Sclerotium rolfsii Lectin Variants

open access: yesMolecules, 2015
SRL is a cell wall associated developmental-stage specific lectin secreted by Sclerotium rolfsii, a soil-born pathogenic fungus. SRL displays specificity for TF antigen (Galβ1→3GalNAc-α-Ser//Thr) expressed in all cancer types and has tumour suppressing ...
Vassiliki I. Peppa   +12 more
doaj   +1 more source

Tn-syndrome.

open access: yes, 1999
The idiopathic Tn-syndrome, formerly called ‘permanent mixed-field polyagglutinability’, is a rare hematological disorder characterized by the expression of the Tn-antigen on all blood cell lineages.
Berger EG
core   +1 more source

Natural anti-Tn-reactive IgM (cross-reactive anti-A isoagglutinin) is neutralized by blood group A phenotype- determining glycosylation, as evident in SARS-CoV-2 (COVID-19) infection 

open access: yes, 2023
   Exposure of a human host to SARS-CoV-2 results in activation of the host trans-membrane protease serine subtype 2 (TMPRSS2) and the ontogenetic polypeptide GalNAc transferase, resulting in a cross-species, mucin-type O-glycan bridge, the classical Tn ...
Peter Arend (560469)
core   +1 more source

Mucin associated Tn and sialosyl-Tn antigen expression in colorectal polyps. [PDF]

open access: yesGut, 1992
Sialosyl-Tn antigen and its immediate precursor, Tn antigen, are carbohydrate structures associated with the earliest steps of mucin O-linked glycosylation. Both antigens have been shown previously to be highly sensitive and specific markers of colorectal cancer.
S H, Itzkowitz   +3 more
openaire   +2 more sources

CD8+ T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2Kb-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection

open access: yesCell Reports, 2012
To study the CD8+ T cell response against a mouse γ-herpes virus, we generated Kb-MHV-68-ORF8604–612RAG−/− CD8+ T cell receptor transnuclear (TN) mice as a source of virus-specific CD8+ T cells.
Sharvan Sehrawat   +8 more
doaj   +1 more source

Identifizierung und funktionelle Charakterisierung von Glykomimetika für das Tn-Antigen [PDF]

open access: yes, 2012
Das Tn-Antigen (CD 175) ist ein mit Serin oder Threonin O-glykosidisch verbundener N-Acetylgalaktosamin-Rest und stellt den ersten Schritt in der Biosynthese der GalNac-O-Glykane dar.
Bruhn, Sandra
core  

Short synthetic glycopeptides successfully induce antibody responses to carcinoma-associated Tn antigen.

open access: yes, 2000
International audienceGlycopeptides containing a tumor-associated carbohydrate antigen (mono-, tri- or hexa-Tn antigen) as a B-cell epitope and a CD4+ T-cell epitope (PV: poliovirus or TT: tetanus toxin) were prepared for immunological studies.
Deriaud, E.   +14 more
core   +1 more source

Presence of the Tn antigen on hematopoietic progenitors from patients with the Tn syndrome. [PDF]

open access: yesJournal of Clinical Investigation, 1985
The Tn syndrome is an acquired clonal disorder characterized by the exposure of a normally hidden determinant, the Tn antigen, on the surface of human erythrocytes, platelets, granulocytes, and lymphocytes. Two distinct populations, Tn positive (Tn+) and Tn negative (Tn-), of mature hemopoietic cells are present in Tn patients. To determine whether the
W, Vainchenker   +7 more
openaire   +2 more sources

Cosmc Disruption-Mediated Aberrant O-glycosylation Suppresses Breast Cancer Cell Growth via Impairment of CD44

open access: yesCancer Management and Research, 2020
Tan Du, 1,* Xingyuan Jia, 2,* Xichen Dong, 2 Xiaoli Ru, 3 Lina Li, 2 Yakun Wang, 2 Jian Liu, 2 Guosheng Feng, 1 Tao Wen 2 1Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China;
Du T   +8 more
doaj  

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