Results 31 to 40 of about 583,823 (157)

Synthesis of cholera toxin B subunit glycoconjugates using site-specific orthogonal oxime and sortase ligation reactions

Frontiers in Chemistry, 2022
The chemoenzymatic synthesis of a series of dual N- and C-terminal–functionalized cholera toxin B subunit (CTB) glycoconjugates is described. Mucin 1 peptides bearing different levels of Tn antigen glycosylation [MUC1(Tn)] were prepared via solid-phase ...
Jonathan P. Dolan, Darren C. Machin, Simone Dedola, Robert A. Field, Robert A. Field, Michael E. Webb, W. Bruce Turnbull   +6 more
doaj   +1 more source

Sialyl-tn antigen expression in Crohn's colitis [PDF]

Inflammatory Bowel Diseases, 1997
: Expression of the mucin-associated sialyl-Tn (STn) antigen is correlated with malignant progression in the colon. In patients with longstanding ulcerative colitis (UC) who never exhibited colonic dysplasia, STn was expressed in fewer than 15% of nondysplastic surveillance colonoscopic biopsies, whereas matched patients who developed colon cancer ...
A, Ta, N, Harpaz, C, Bodian, A, Roston, L, Oberman, A, Chen, S, Itzkowitz   +6 more
openaire   +2 more sources

The GalNAc-T Activation Pathway (GALA) is not a general mechanism for regulating mucin-type O-glycosylation.

PLoS ONE, 2017
Mucin-type O-glycosylation is initiated by the UDP-GalNAc polypeptide:N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. Their activity results in the GalNAc α1-O-Thr/Ser structure, termed the Tn antigen, which is further decorated with ...
Gaetan G Herbomel, Raul E Rojas, Duy T Tran, Monica Ajinkya, Lauren Beck, Lawrence A Tabak   +5 more
doaj   +1 more source

Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer

, 2020
Colorectal cancer (CRC) cells often express Tn antigen, a tumor-associated truncated immature O-glycan (GalNAcα-O-Ser/Thr) that can promote tumor progression.
Hiroshi Nakano, Shotaro Fujita, Misato Ito, Leo Yamada, Shotaro Nakajima, Motonobu Saito, Zenichiro Saze, Eisei Endo, Naoto Yamauchi, Hirokazu Okayama, Tomoyuki Momma, Yasuyuki Kanke, Katsuharu Saito, Kosaku Mimura, Koji Kase, Koji Kono, Takuro Matsumoto, Wataru Sakamoto, Hisashi Onozawa   +18 more
core   +1 more source

Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens

Cancer Management and Research, 2020
Feng Xu,1,* Dong Wang,2,* JianXiu Cui,1 Jie Li,1 Hongchuan Jiang1 1Department of Breast Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China; 2Department of Oncology, Affiliated Hospital of ...
Xu F, Wang D, Cui J, Li J, Jiang H
doaj  

Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers

BMC Cancer, 2018
Background The Tn neoantigen (GalNAcα1-O-Ser/Thr) is an O-glycan expressed in various types of human cancers. Studies in several Tn-expressing cancer cell lines and pancreatic tumors have identified loss of Cosmc expression caused by either mutations or ...
Xiaodong Sun, Tongzhong Ju, Richard D. Cummings   +2 more
doaj   +1 more source

Truncated lubricin glycans in osteoarthritis stimulate the synoviocyte secretion of VEGFA, IL-8, and MIP-1α: Interplay between O-linked glycosylation and inflammatory cytokines

Frontiers in Molecular Biosciences, 2022
The primary aim of the study was to identify inflammatory markers relevant for osteoarthritis (OA)-related systemic (plasma) and local (synovial fluid, SF) inflammation.
Shan Huang, Kristina A. Thomsson, Chunsheng Jin, Henrik Ryberg, Nabangshu Das, Nabangshu Das, André Struglics, Ola Rolfson, Lena I. Björkman, Thomas Eisler, Tannin A. Schmidt, Gregory D. Jay, Roman Krawetz, Roman Krawetz, Niclas G. Karlsson, Niclas G. Karlsson   +15 more
doaj   +1 more source

Polymeric nanoparticles targeting Sialyl-Tn in gastric cancer: A live tracking under flow conditions

Materials Today Bio, 2022
Drug delivery using nanoparticles (NPs) represents a potential approach for therapy in cancer, such gastric cancer (GC) due to their targeting ability and controlled release properties.
Francisca Diniz, Maria Azevedo, Flávia Sousa, Hugo Osório, Diana Campos, Paula Sampaio, Joana Gomes, Bruno Sarmento, Celso A. Reis   +8 more
doaj   +1 more source

Anti-Tn Monoclonal Antibody Ameliorates Hyperoxia-Induced Kidney Injury by Suppressing Oxidative Stress and Inflammation in Neonatal Mice

Mediators of Inflammation, 2021
The Tn antigen, an N-acetylgalactosamine structure linked to serine or threonine, has been shown to induce high-specificity, high-affinity anti-Tn antibodies in mice.
Julie Chi Chow, Hsiu-Chu Chou, Jaulang Hwang, Chung-Ming Chen   +3 more
doaj   +1 more source

Amplified Detection of Breast Cancer Autoantibodies Using MUC1-Based Tn Antigen Mimics [PDF]

, 2020
In many human carcinomas, mucin-1 (MUC1) is overexpressed and aberrantly glycosylated, resulting in the exposure of previously hidden antigens. This generates new patient antibody profiles that can be used in cancer diagnosis.
Hinou, Hiroshi [0000-0003-2223-7300], Sánchez-Fernández, Elena M. [0000-0002-8617-8234], Artigas, Gerard, Ortiz Mellet, Carmen [0000-0002-7676-7721], Nishimura, Shin-Ichiro, García Fernández, José Manuel, Guillen-Poza, Pablo A., Garcia-Martin, Fayna [0000-0001-9118-3874], Hiroshi Hinou, Gerard Artigas, Shin-Ichiro Nishimura, Elena M. Sánchez-Fernández, Fayna Garcia-Martin, José Manuel García Fernández, Pablo A. Guillen-Poza, Carmen Ortiz Mellet   +15 more
core   +1 more source