Results 11 to 20 of about 583,823 (157)

Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine

European Journal of Histochemistry, 2009
Tn, sialosyl-Tn and T antigens are simple mucintype carbohydrate antigens that may be expressed in human neoplasies due to alteration of the glycoprotein biosynthetic pathway.
M Grosso, E Vitarelli, G Giuffrè, G Tuccari, G Barresi   +4 more
doaj   +3 more sources

The (Sialyl) Tn antigen: Contributions to immunosuppression in gastrointestinal cancers

Frontiers in Oncology, 2023
Cellular signaling pathways are intricately regulated to maintain homeostasis. During cancer progression, these mechanisms are manipulated to become harmful. O-glycosylation, a crucial post-translational modification, is one such pathway that can lead to
Christabelle Rajesh, Prakash Radhakrishnan   +1 more
doaj   +1 more source

Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]

, 1994
The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G., Berger, Eric G, Mechtler, Karl, Rusconi, Sandro, Wagner, Ernst, Birnstiel, Max L., Cotten, Matt, Clausen, Erik, Dinter, André, Thurnher, Martin, Berger, Erik G., Clausen, Henrik, Birnstiel, Max L, Wagner E, Cotten M, Clausen H, Mechtler K, Rusconi S, Birnstiel ML, Thurnher M, Berger EG, Dinter A   +21 more
core   +1 more source

Side population cells derived from hUCMSCs and hPMSCs could inhibit the malignant behaviors of Tn+ colorectal cancer cells from modifying their O-glycosylation status

Stem Cell Research & Therapy, 2023
Background Cosmc (C1GalT1C1) mutation could cause aberrant O-glycosylation and result in expression of Tn antigen on the surface of tumor cells (Tn+ cells), which is associated with the metastasis and prognosis of cancer progression.
Wen Hu, Ruisong Ding, Mengyang Wang, Panpan Huang, Xia Wei, Xingyou Hu, Tao Hu   +6 more
doaj   +1 more source

Effect of anticancer therapy on Tn antigen exposure on the leucocyte membranes in patients with leukemia

Regulatory Mechanisms in Biosystems, 2014
Tn-antigen (Thomsen-nouvelle antigen) is tumor-associated carbohydrate antigen with only one GalNAc residue attached to serine or threonine of polypeptide chain.
G. S. Maslak
doaj   +1 more source

Expression of tumor-associated antigens in breast cancer subtypes

Breast, 2020
Objectives: Tumor-associated antigens (TAAs) are frequently overexpressed in several cancer types. The aim of this study was to investigate the expression of TAAs in breast cancer.
Giuseppe Curigliano, Vincenzo Bagnardi, Mariacristina Ghioni, Jamila Louahed, Vincent Brichard, Frederic F. Lehmann, Antonio Marra, Dario Trapani, Carmen Criscitiello, Giuseppe Viale   +9 more
doaj   +1 more source

Oxygen by Carbon Replacement at the Glycosidic Linkage Modulates the Sugar Conformation in Tn Antigen Mimics [PDF]

, 2018
N-Acetylgalactosamine (GalNAc) α-O-linked to l-threonine (Thr) (Tn antigen) and several mimics of this Tn antigen have been synthesized to explore the impact of the underlying amino acid in the presentation mode of the carbohydrate moiety. The structural
Alberto Avenoza (1470724), Corzana, Francisco [0000-0001-5597-8127], Matías, Cristina, Iris A. Bermejo (4677730), Gonzalo Jiménez-Osés, Jesús M. Peregrina, Jesús H. Busto (1470733), Bermejo, Iris A. [0000-0001-8864-4852], Claudio D. Navo (1470727), Pablo Tovillas, Cristina Matías (6116069), Busto, Jesús H. [0000-0003-4403-4790], Francisco Corzana (1470730), Alberto Avenoza, Francisco Corzana, Pablo Tovillas (5099498), Navo, Claudio D. [0000-0003-0161-412X], Peregrina, Jesús M. [0000-0003-3778-7065], Cristina Matías, Claudio D. Navo, Companón, Ismael, Paula Oroz (5099504), Ismael Compañón, Gonzalo Jiménez-Osés (1340502), Avenoza, Alberto [0000-0002-5465-3555], Ismael Compañón (1858135), Paula Oroz, María M. Zurbano, Jiménez-Osés, Gonzalo [0000-0003-0105-4337], Oroz, Paula [0000-0003-0854-5059], Tovillas, Pablo, Zurbano, María M. [0000-0001-6370-3537], Jesús M. Peregrina (1470736), Jesús H. Busto, María M. Zurbano (1830772), Iris A. Bermejo, Busto, Jesús H., Oroz, Paula, Avenoza, Alberto, Corzana, Francisco, Peregrina, Jesús M., 0000-0003-3778-7065, 0000-0003-0105-4337, Zurbano, María M., Bermejo, Iris A., 0000-0001-5597-8127, Navo, Claudio D., Jiménez-Osés, Gonzalo   +47 more
core   +1 more source

An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8+ T cells

Frontiers in Immunology, 2023
Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells and, therefore, the quality of the T-cell response. Here we describe that the maturation of DCs via TriMix mRNA, encoding CD40 ligand, a constitutively active ...
Wout de Mey, Hanne Locy, Kirsten De Ridder, Phaedra De Schrijver, Dorien Autaers, Asma Lakdimi, Arthur Esprit, Lorenzo Franceschini, Kris Thielemans, Magali Verdonck, Karine Breckpot   +10 more
doaj   +1 more source

Synthesis of Tn Antigen Mimetics and Their Incorporation into the MUC1 Glycoprotein Sequence [PDF]

, 2022
Cancer is a disease with one of the highest mortality rates in the first world countries and its treatment today is still invasive and often ineffective.
J. M. Peregrina [0000-0003-3778-7065], C. Bretón [0000-0002-3531-6676], P. Oroz [0000-0003-0854-5059], I. Compañón, F. Corzana [0000-0001-5597-8127]   +4 more
core  

Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease

Biomolecules, 2022
The core-1 β1-3galactosyltransferase-specific chaperone 1 (Cosmc) is a unique molecular chaperone of core-1 β1-3galactosyltransferase(C1GALT1), which typically functions inside the endoplasmic reticulum (ER).
Ting Xiang, Muchuan Qiao, Jiangbo Xie, Zheng Li, Hailong Xie   +4 more
doaj   +1 more source