Results 21 to 30 of about 583,823 (157)

Expression of the Tn antigen on erythroid cells from a patient with Tn syndrome [PDF]

Japanese journal of human genetics, 1992
In order to examine expression of the Tn antigen on erythroid cells from a patient with Tn syndrome, we applied a selective two phase liquid culture system for human erythroid progenitors in peripheral blood. The cells were analyzed with flow cytometry employing an anti-Tn antibody and a lectin of Vicia villosa which recognizes only the Tn determinant.
Y, Kamitani, E, Kajii, T, Suda, S, Ikemoto   +3 more
openaire   +2 more sources

Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens [Retraction]

Cancer Management and Research, 2022
Xu F, Wang D, Cui J, Li J, Jiang H. Cancer Manag Res. 2020;12:1017–1027. At the authors request, the Editor and Publisher of Cancer Management and Research wish to retract the published article.
Xu F, Wang D, Cui J, Li J, Jiang H
doaj  

Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development

Acta Pharmaceutica Sinica B, 2022
We present a new strategy for self-adjuvanting vaccine development that has different types of covalently-linked immunostimulants as the carrier molecule.
Deying Yang, Xiang Luo, Qinghai Lian, Lingqiang Gao, Chengxin Wang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Guochao Liao   +8 more
doaj   +1 more source

Different expression of Tn and sialyl-Tn antigens between normal and diseased human gastric epithelial cells. [PDF]

, 1998
Thomsen-Friedenreich antigen (T antigen) has been supposed to be a cancer-specific carbohydrate antigen. We have previously shown that one third of the Japanese population normally expressed T antigen in gastric surface epithelia and the other two thirds
Tsuji, Takao, Nakatou, Tatsuaki, Sotozono, Masaaki, Yoshida, Atushi, Okada, Yoshio   +4 more
core   +1 more source

Targeting Tn-Antigen-Positive Human Tumors with a Recombinant Human Macrophage Galactose CType Lectin

, 2021
Alterations in glycosylation cause the emergence of tumor-associated carbohydrate antigens (TACAs) during tumorigenesis. Truncation of O-glycans reveals the Thomsen nouveau (Tn) antigen, an N-acetylgalactosamine (GalNAc) frequently attached to serine or ...
Maxime Henry (4376956), Corinne Vivès (2384077), Christine Ebel (129858), Amandine Hurbin (749682), Aline Le Roy, Franck Fieschi, François Bulteau (11857258), Jean-Luc Coll, Olivier Renaudet (363908), Amandine Hurbin, Michel Thépaut (1788882), Laetitia Vanwonterghem (11857261), Christine Ebel, Jean-Luc Coll (32116), Michel Thépaut, Franck Fieschi (296308), François Bulteau, Olivier Renaudet, Aline Le Roy (10099505), Maxime Henry, Laetitia Vanwonterghem, Corinne Vivès   +21 more
core   +1 more source

Efficient and Reproducible Synthesis of an Fmoc-protected Tn Antigen [PDF]

, 2021
The total synthesis of the Thomsen-nouveau (Tn) antigen, a tumour-associated O-linked mucin glycopeptide, was achieved through a concise route. The key glycosylation step proved challenging to reproduce from the literature precedents and was most ...
John F., Trant, Sabrina, Piazza, Fabiola A., Chapa-Villarreal, Jonathan, Chiaramonte, Michael R., Reynolds   +4 more
core   +1 more source

Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG

Scientific Reports, 2023
The aberrant expression of the Tn antigen (CD175) on surface glycoproteins of human carcinomas is associated with tumorigenesis, metastasis, and poor survival.
Yasuyuki Matsumoto, Nan Jia, Jamie Heimburg-Molinaro, Richard D. Cummings   +3 more
doaj   +1 more source

Shigella flexneri targets human colonic goblet cells by O antigen binding to Sialyl-Tn and Tn antigens via glycan-glycan interactions

, 2020
Shigella flexneri targets colonic cells in humans to initiate invasive infection processes that lead to dysentery, and direct interactions between their lipopolysaccharide O antigens and blood group A related glycans are involved in the cell adherence ...
Tran, ENH, Poole, J., Tran, E.N.H., Tse, E., Jennings, M.P., Morona, R, Poole, J, Tse, E, Day, C.J., McCartney, E., Day, CJ, Jennings, MP, McCartney, E, Morona, R.   +13 more
core   +1 more source

The Tn Antigen—Structural Simplicity and Biological Complexity [PDF]

Angewandte Chemie International Edition, 2011
AbstractGlycoproteins in animal cells contain a variety of glycan structures that are added co‐ and/or posttranslationally to proteins. Of over 20 different types of sugar–amino acid linkages known, the two major types are N‐glycans (Asn‐linked) and O‐glycans (Ser/Thr‐linked).
Ju, Tongzhong, Otto, Vivianne I., Cummings, Richard D.   +2 more
openaire   +3 more sources

Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model

Journal for ImmunoTherapy of Cancer, 2023
Background Treatment of some blood cancers with T cells that express a chimeric antigen receptor (CAR) against CD19 have shown remarkable results. In contrast, CAR-T cell efficacy against solid tumors has been difficult to achieve.Methods To examine the ...
David M Kranz, Edward J Roy, Preeti Sharma, Diana Rose E Ranoa, Claire P Schane, Amber N Lewis, Edward Valdez, Venkata V V R Marada, Marlies V Hager, Will Montgomery, Steven P Wolf, Karin Schreiber, Hans Schreiber, Keith Bailey, Timothy M Fan, Paul J Hergenrother   +15 more
doaj   +1 more source