Results 41 to 50 of about 583,823 (157)

Lung Tumor Cells with Different Tn Antigen Expression Present Distinctive Immunomodulatory Properties [PDF]

, 2022
Lung cancer is the first leading cause of cancer-related deaths in the world. Aberrant glycosylation in lung tumors leads to the expression of tumor-associated carbohydrate structures, such as the Tn antigen, consisting of N-acetyl-galactosamine (GalNAc)
Rodríguez-Zraquia, Santiago A., Lores, Pablo, Mariño, Karina V., María Florencia Festari, Mariño, Karina Valeria, Vliet, Sandra J. van, Rabinovich, Gabriel A., da Costa, Valeria, Gabriel A. Rabinovich, Monique Costa, Freire, Teresa, Karina V. Mariño, Sandra J. van Vliet, van Vliet, Sandra J., Valeria da Costa, Landeira, Mercedes, Costa, Monique, Rabinovich, Gabriel Adrián, Teresa Freire, Festari, María Florencia, Santiago A. Rodríguez-Zraquia, Pablo Lores, Mercedes Landeira, Rodríguez Zraquia, Santiago A.   +23 more
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Anti-Tn/anti-A cross-reactive IgM function is compromised by ABO(H) phenotype-determining glycosylation, as evident in SARS-CoV-2 (COVID-19) infection

, 2022
  Exposure of a human host to SARS-CoV-2 results in activation of the host trans-membrane protease serine subtype 2 (TMPRSS2) and the ontogenetic polypeptide GalNAc transferase, forming a cross-species, mucin-type molecular O-glycan bridge, the classical
Peter Arend (560469)
core   +1 more source

Tn, a carcinoma-associated antigen, reacts with anti-Tn of normal human sera [PDF]

Cancer, 1985
Tn antigen is the immediate precursor of the carcinoma (CA)-associated T antigen; both are masked in non-CA tissues. Tn antigen was detected by absorption of human anti-Tn antibody in 46 of 50 primary breast CAs and in all 6 metastases originating from Tn-positive primary CAs.
G F, Springer, C R, Taylor, D R, Howard, H, Tegtmeyer, P R, Desai, S M, Murthy, B, Felder, E F, Scanlon   +7 more
openaire   +2 more sources

Aberrant Glycosylation of Anchor-Optimized MUC1 Peptides Can Enhance Antigen Binding Affinity and Reverse Tolerance to Cytotoxic T Lymphocytes

Biomolecules, 2016
Cancer vaccines have often failed to live up to their promise, although recent results with checkpoint inhibitors are reviving hopes that they will soon fulfill their promise. Although mutation-specific vaccines are under development, there is still high
Latha B. Pathangey, Vani Lakshminarayanan, Vera J. Suman, Barbara A. Pockaj, Pinku Mukherjee, Sandra J. Gendler   +5 more
doaj   +1 more source

Evaluation of serum CA125-Tn glycoform in peritoneal dissemination and surgical completeness of high-grade serous ovarian cancer

Journal of Ovarian Research, 2022
Background Peritoneal dissemination is the predominant feature of malignant progression in ovarian cancer and is a major cause of poor surgical outcomes and clinical prognoses. Abnormal glycosylation of carbohydrate antigen 125 (CA125) may be involved in
Xiayu Jin, Ming Du, Yisheng Wang, Yuefei Wang, Yingying Lu, Congjian Xu, Xiaoyan Zhang   +6 more
doaj   +1 more source

Tuning CAR-T cells by targeting cancer-associated glycan in pancreatic cancer

Nature Communications
Chimeric antigen receptor (CAR) T cell therapy has transformed cancer treatment but its efficacy remains limited in solid tumors due to antigen heterogeneity, an immunosuppressive microenvironment, and the glycocalyx barrier.
Sangwoo Park, Cassidy E. Ho, Eli P. Darnell, Alexandra N. Wolff, Hana Takei, Filippo Birocchi, Amanda A. Bouffard, Diego Salas-Benito, Giulia Escobar, Mark B. Leick, Adele Mucci, Trisha R. Berger, Marcela V. Maus   +12 more
doaj   +1 more source

Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

, 2020
International audienceTumor associated carbohydrate antigens (TACAs), such as the Tn antigen, have emerged as key targets for the development of synthetic anticancer vaccines.
Fernandez-Tejada, Alberto, Sacristan, Nagore, Tiertant, Claire, Anguita, Juan, Berthet, Nathalie, Renaudet, Olivier, Goyard, David, Pifferi, Carlo, Ruiz-De-Angulo, Ane, Barriales, Diego   +9 more
core   +1 more source

MGL Receptor and Immunity: When the Ligand Can Make the Difference

Journal of Immunology Research, 2015
C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer.
Ilaria Grazia Zizzari, Chiara Napoletano, Federico Battisti, Hassan Rahimi, Salvatore Caponnetto, Luca Pierelli, Marianna Nuti, Aurelia Rughetti   +7 more
doaj   +1 more source

Multi-Modal Single-Cell Sequencing Identifies Cellular Immunophenotypes Associated With Juvenile Dermatomyositis Disease Activity

Frontiers in Immunology, 2022
Juvenile dermatomyositis (JDM) is a rare autoimmune condition with insufficient biomarkers and treatments, in part, due to incomplete knowledge of the cell types mediating disease.
Jessica Neely, George Hartoularos, George Hartoularos, George Hartoularos, Daniel Bunis, Daniel Bunis, Yang Sun, David Lee, David Lee, Susan Kim, Chun Jimmie Ye, Chun Jimmie Ye, Chun Jimmie Ye, Chun Jimmie Ye, Chun Jimmie Ye, Chun Jimmie Ye, Marina Sirota, Marina Sirota   +17 more
doaj   +1 more source

Structurally Constrained MUC1-Tn Mimetic Antigen as Template for Molecularly Imprinted Polymers (MIPs): A Promising Tool for Cancer Diagnostics [PDF]

, 2022
Abnormal glycoconjugates have distinctly been recognized as potential biomarkers for cancer diagnosis. A great deal of attention has been focused on Tn antigen, an oversimplified mucin-1 O-glycan, over-expressed in different cancers.
Palladino, Pasquale, Papi, Francesco, Pasquale Palladino, Scarano, Simona, Maria Minunni, Simona Scarano, Minunni, Maria, Nativi, Cristina, Francesco Papi, Cristina Nativi   +9 more
core   +1 more source