Results 131 to 140 of about 81,406 (283)

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

The Role of Primary Tumor Resection in De Novo Bone‐Only Metastatic Breast Cancer: A Propensity Score‐Matched Analysis

Journal of Surgical Oncology, EarlyView.
ABSTRACT Objective To evaluate the impact of primary tumor resection (PTR) on overall survival (OS) and cancer‐specific survival (CSS) in women with de novo bone‐only metastatic breast cancer (MBC). Methods Women diagnosed with de novo bone‐only metastatic breast cancer between 2010 and 2017 were identified from the Surveillance, Epidemiology, and End ...
Bin Wang, Shasha Liu, Zhidong Huang, Jinhui Wang, Xirui Zhou, Shuo Li, Jianan Chen, Hong Liu   +7 more
wiley   +1 more source

Circ_0006174 Drives Triple Negative Breast Cancer Progression and Immune Escape Through Regulating miR‐3139/PD‐L1 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is characterized as an aggressive malignancy with limited therapeutic options. The circular RNA circ_0006174 has been implicated in oncogenic processes across various cancers; however, its specific role in the pathogenesis of TNBC remains unclear.
Yong‐Zhe Tang, Li Yang, Ling Wang, Xiao‐Qing Zhang, Jie Wang   +4 more
wiley   +1 more source

Programmed Cell Death Ligand 1 (PD-L1) and major Histocompatibility Complex Class I (MHC Class I) Expression Patterns and Their Pathologic Associations in triple-Negative Breast Cancer

Breast Cancer: Targets and Therapy
Ponkrit Kaewkedsri,1 Piyapharom Intarawichian,1 Sirawich Jessadapattarakul,1 Waritta Kunprom,1 Supinda Koonmee,1 Malinee Thanee,1 Ongart Somintara,2 Anongporn Wongbuddha,2 Payia Chadbunchachai,3 Supajit Nawapun,3 Chaiwat Aphivatanasiri1 1Department of ...
Kaewkedsri P, Intarawichian P, Jessadapattarakul S, Kunprom W, Koonmee S, Thanee M, Somintara O, Wongbuddha A, Chadbunchachai P, Nawapun S, Aphivatanasiri C   +10 more
doaj  

Multiomics Analysis of Gene Expression and Drug Sensitivity Relationship in Breast Cancer Subtypes

Online Academic Journal of Information Technology
Breast cancer is a complex disease exhibiting distinct clinical behaviors due to its molecular heterogeneity. In this study, 30 breast cancer cell lines were categorized into two main analysis groups: 'Hormone/HER2 Positive' (n=12) and 'TNBC' (triple ...
Adem Sonuvar, Esra Tokur Sonuvar, Uğur Bilge   +2 more
doaj   +1 more source

Integrative analysis of the inter-tumoral heterogeneity of triple-negative breast cancer. [PDF]

, 2018
Triple-negative breast cancers (TNBC) lack estrogen and progesterone receptors and HER2 amplification, and are resistant to therapies that target these receptors.
Boymoushakian, Lari, Chiu, Alec M, Coller, Hilary A, Mitra, Mithun   +3 more
core  

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

TNBC and super-enhancers

This document is about the code for super-enhancer analysis in ...
openaire   +1 more source

Topological analysis of the human lymph node reticular network predicts outcome in breast cancer

The Journal of Pathology, EarlyView.
Abstract Axillary LNs (ALNs) initiate immune responses in breast cancer (BC) but how and when ALNs become dysfunctional, facilitating metastasis, is unclear. The fibroblastic reticular cell (FRC) network within ALNs provides structural support and mediates immune homeostasis, but we have yet to elucidate whether this network changes during BC ...
Amy M Llewellyn, Sharon L D'Costa, Cheun YR Lam, Jasmine A Gore, Veronika Lachina, Daniel J Shewring, Sophie E Acton, Kalnisha Naidoo   +7 more
wiley   +1 more source

Proteomic Characterization of AS1411 Reveals ATP6AP1 as a Mediator of Triple‐Negative Breast Cancer Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential, poor prognosis, and limited effective therapeutic options. In this study, we investigated the molecular mechanisms underlying the anticancer effects of the nucleolin (NCL)‐targeting DNA aptamer AS1411 using label‐free ...
Ha‐Song Bae, Yun‐Jeong Seo, Eun‐Bi Kim, Hyoung‐Min Park, I‐Hsuan Liu, J. Eugene Lee, Jae‐Young Kim   +6 more
wiley   +1 more source