Results 131 to 140 of about 51,359 (249)

The tumor microenvironment in triple negative breast cancer and a strategy to improve responses to immunotherapy using cryoablation and immunostimulants. [PDF]

Cancer Biol Ther
Illindala R, Yang Y, Mandt T, Webster N, Steinmetz N, Newton I.   +5 more
europepmc   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Computational identification of putative mRNA-miRNA signatures in chemoresistant and metastatic triple-negative breast cancer. [PDF]

Biochem Biophys Rep
Farajzadeh-Dehkordi M, Rezvani Boroujeni E, Darzi S, Jalilvand M, Rahmani B.   +4 more
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Targeting erbB Pathways in Breast Cancer: Dual Kinase Inhibition for Brain Metastasis and Prevention of p185HER2/Neu Tumor Development

Breast Cancer: Targets and Therapy
Peeyush N Goel,1,2,* Makoto Katsumata,3,* Wei Qian,4 Sunil Mathur,4 Mei Q Ji,1 Arabinda Samanta,1 Payal Grover,1 George Sgouros,5 Jenny C Chang,4 Mark I Greene1 1Department of Pathology and Laboratory Medicine, Perelman School of Medicine ...
Goel PN, Katsumata M, Qian W, Mathur S, Ji MQ, Samanta A, Grover P, Sgouros G, Chang JC, Greene MI   +9 more
doaj  

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Exploration of Traditional Chinese Medicine Comprehensive Treatment of Triple Negative Breast Cancer Based on Molecular Pathological Mechanism

Breast Cancer: Targets and Therapy
Mingya Zhu,1 Yongqin Liu,1 Zhu Wen,1 Hao Tan,1 Siman Li,1 Xinkang Yu,1 Hongping Luo,1 Delin Li,1 Jinyan Wang,1 Fangyan Qin2 1Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, People’s Republic of China; 2The Second People’s ...
Zhu M, Liu Y, Wen Z, Tan H, Li S, Yu X, Luo H, Li D, Wang J, Qin F   +9 more
doaj  

Targeting DNA Polymerase Epsilon Induces Tumor Clearance and Activates an NF-κB-Mediated Inflammatory Response in Triple-Negative Breast Cancer. [PDF]

Cancer Res
Sher EF, Fujihara KM, Tao A, Sastourne-Haletou P, Erenburg D, Sviderskiy VO, Mir H, Karakousi T, Loomis CA, Deng J, Ruggles KV, Wong KK, Possemato R.   +12 more
europepmc   +1 more source

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

AKT inhibition improves OS in TNBC [PDF]

Nature Reviews Clinical Oncology, 2020
openaire   +2 more sources