Results 151 to 160 of about 74,225 (263)
Clinical Challenges in Triple-Negative Breast Cancer (TNBC): Current Treatment Options, Their Limitations, and Emerging Perspectives. [PDF]
Cancers (Basel)Deka R, Singh TR.
europepmc +1 more source
Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles
Mass Spectrometry Reviews, EarlyView.ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág +5 more
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The Journal of Pathology, EarlyView.Abstract Fibroblast growth factor receptor 1 (FGFR1) amplification, a significant cancer alteration with both prognostic and therapeutic relevance, lacks a standardized definition. The relationship between FGFR1 copy number (CN) variations and tumour microenvironment (TME) characteristics also remains poorly understood.
Yike Gao +6 more
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SLC7A5: A Potential Molecular Target for the Diagnosis and Treatment of TNBC
TNBC is a highly heterogeneous malignant tumor with limited clinical treatment options and efficacy. Through a series of analyses and screenings, we have identified SLC7A5 as a potential biomarker for targeted therapy of TNBC.
Jincheng Wang +8 more
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PROTEOMICS, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca +7 more
wiley +1 more source
Cancer-associated fibroblasts in triple-negative breast cancer: heterogeneity, tumor-stroma crosstalk, and therapeutic resistance. [PDF]
Front OncolWei S, Xie X, Cao Y, Wei L.
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Precision Medical Sciences, EarlyView.High IL6 expression correlates with shorter relapse‐free survival in the basal‐like breast cancer subtype. Nanobacteria‐like particles (NB‐LPs) significantly reduce breast cancer cell viability and IL6 expression levels in MDA‐MB‐231 cells. Abstract Breast cancer is one of the most prevalent malignancies among women worldwide.
Fateme Nikakhtar +2 more
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Baicalin Induces Ferroptosis in Breast Cancer Through a Novel STAT3/HO‐1/GPX4 Regulatory Axis
Phytotherapy Research, EarlyView.BA inhibits STAT3 phosphorylation and activation in BC cells, accompanied by decreased expression of HO‐1 and GPX4. Reduced GPX4 activity impairs lipid peroxide clearance, promoting ROS accumulation and lipid peroxidation, which ultimately triggers ferroptosis and inhibits cell proliferation.
Tingting Guo +11 more
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Breast Cancer: Targets and TherapyPeeyush N Goel,1,2,* Makoto Katsumata,3,* Wei Qian,4 Sunil Mathur,4 Mei Q Ji,1 Arabinda Samanta,1 Payal Grover,1 George Sgouros,5 Jenny C Chang,4 Mark I Greene1 1Department of Pathology and Laboratory Medicine, Perelman School of Medicine ...
Goel PN +9 more
doaj
Plant‐Derived Extracellular Vesicles: Biogenesis, Function, and Application in Cancer Immunotherapy
Phytotherapy Research, EarlyView.This illustration shows the biogenesis pathways of edible and medicinal plant‐derived extracellular vesicles (PDEVs) and their therapeutic effects following uptake in the human body, highlighting their potential for application in cancer immunotherapy. ABSTRACT Plant‐derived extracellular vesicles (PDEVs) are nanoscale, lipid bilayer‐enclosed vesicles ...
Guosheng Li +4 more
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