Results 141 to 150 of about 74,225 (263)

Impact of Single‐Cell RNA Reference Selection for the Deconvolution of Breast Cancer Spatial Transcriptomics Datasets

International Journal of Cancer, EarlyView.
ABSTRACT Spot‐based spatial transcriptomics (ST) allows for unbiased gene expression analysis within tissue architecture, overcoming the limitations of single‐cell RNA sequencing (scRNA‐seq) by preserving spatial context. However, the high spatial resolution in ST leads to cellular heterogeneity within spots, requiring computational deconvolution to ...
Stefan Altendorfer, Scott J. Walker, Carsten O. Daub   +2 more
wiley   +1 more source

Single-cell transcriptomic analysis reveals the immunosuppressive status of NK cell subpopulations in TNBC

Triple-negative breast cancer (TNBC), lacking expression of the estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), has clinical features that include high invasiveness, limited response to current ...
Weizhen Xu, Wen-Ming Cao, Yang Liu, Ying Jin   +3 more
core   +1 more source

Cardiometabolic Health and Risk of Breast Cancer Subtypes Among US Black Women

International Journal of Cancer, EarlyView.
ABSTRACT In the United States (US), cardiometabolic conditions and aggressive breast cancers are both more common among Black women than White women. Using data from 57,453 participants in the Black Women's Health Study (BWHS), we prospectively evaluated associations of body mass index (BMI), Type 2 diabetes, hypertension, and hypercholesterolemia with
Yifei Shan, Sarah M. Rothbard, Lynn Rosenberg, Julie R. Palmer, Mollie E. Barnard   +4 more
wiley   +1 more source

Transcriptomic analysis reveals potential crosstalk genes and immune relationship between triple-negative breast cancer and depression

Discover Oncology
TNBC, the most aggressive form of breast cancer, lacks accurate and effective therapeutic targets. Immunotherapy presents a promising approach for addressing TNBC. Anxiety and depression are frequently concurrent symptoms in TNBC patients.
Zhili Zhuo, Wenping Lu, Ling Zhang, Dongni Zhang, Yongjia Cui, Xiaoqing Wu, Heting Mei, Lei Chang, Qingya Song   +8 more
doaj   +1 more source

Incidence and Predictors of Immune‐Related Hypothyroidism Under Pembrolizumab Across Gynecologic Malignancies and Melanoma: A Real‐World Cohort Study

International Journal of Cancer, EarlyView.
ABSTRACT Immune checkpoint inhibitors (ICIs) frequently cause thyroid immune‐related adverse events (irAEs). Permanent hypothyroidism, the clinically most relevant phenotype, requires lifelong hormone replacement. We investigated its incidence, course, risk factors, and prognostic relevance under pembrolizumab.
Freya Koffka, Johann Kornowski, Elena Laakmann, Barbara Schmalfeldt, Tim Zell, Glenn Geidel, Christoffer Gebhardt, Pia Roser, Volkmar Müller, Julian Kött   +9 more
wiley   +1 more source

S100A8/A9 Drives Emergency Granulopoiesis to Promote Triple‐Negative Breast Cancer Metastasis

iNew Medicine, EarlyView.
ABSTRACT Objective Triple‐negative breast cancer (TNBC) is an aggressive subtype of breast cancer characterized by high metastatic potential and limited therapeutic options. Although neutrophils contribute to tumor progression, how tumors systemically regulate neutrophil production remains poorly understood.
Hami Hemati, Dong Li, Younhee Park, Jinpeng Liu, Xueqing Wang, Xia Liu   +5 more
wiley   +1 more source

Comparison of Continuous‐Time Random Walk and Fractional Order Calculus Diffusion Models for Preoperative Breast Lesion Characterization: Diagnosis, Biomarker Prediction and Molecular Subtyping

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Accurate preoperative characterization of breast lesions is important for individualized management. The conventional monoexponential (Mono) model has limited ability to capture the complex microstructure of lesions. Non‐Gaussian diffusion models, including continuous‐time random walk (CTRW) and fractional‐order calculus (FROC), may
Yimeng Cao, Shaomin Li, Zhexuan Yang, Xueyan Liu, Shifang Tan, Tian Ren, Wenjia Wang, Haiyang Li, Xingzhi Chen, Xin Zhao, Meiying Cheng   +10 more
wiley   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Risk Factors Influencing Efficacy and Prognosis Evaluation of Neoadjuvant Systemic Therapy in Triple‐Positive Breast Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT To identify the determinants of the response to neoadjuvant systemic therapy (NST) in triple‐positive breast cancer (TPBC), we retrospectively enrolled 520 patients with human epidermal growth factor receptor 2 (HER2)‐positive breast cancer who were treated at The First Affiliated Hospital of Chongqing Medical University between January 2015 ...
Lin‐Rui Miao, Hao Liu, Hai‐Ying Yu, Jian Chen, Ming‐Yu Yang, Ya‐Lan Zhang, Gang Tu, Ling‐Feng Tang   +7 more
wiley   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source