Results 181 to 190 of about 74,225 (263)

Nano-/Nanobiotechnology-Augmented Pyroptosis in the Treatment of Triple-Negative Breast Cancer: An Updated Review. [PDF]

Int J Nanomedicine
Yang J, Guo W, Pang X, Li Z, Wu X, Gui Y, Ma D.   +6 more
europepmc   +1 more source

Multi‐Omics Integration Reveals Metabolic Reprogramming and EMT‐Driven Metastasis in Triple‐Negative Breast Cancer

Cancer Science, EarlyView.
Integrated transcriptomic, metabolomic, and spatial proteomic profiling of TNBC tumors identifies a metastatic‐associated molecular landscape characterized by EMT activation, metabolic reprogramming, and tumor microenvironment (TME) remodeling. Multi‐omics integration reveals coordinated alterations in EMT signatures, amino acid metabolism, immune ...
Yuheng Pang, Yuefeng Shang, Wenjing Wang, Tong Liu, Xiaolong Zou   +4 more
wiley   +1 more source

Metabolic targeting of ASAH1 in combination with carnosine as a therapeutic strategy for TNBC. [PDF]

Mol Metab
T Ball P, Mari A, Gupta R.
europepmc   +1 more source

Real‐World Germline Variant Landscape and Clinical Management in Korean Patients Tested for Suspected Hereditary Cancer

Cancer Science, EarlyView.
In 5829 Korean patients undergoing hereditary cancer germline testing, 987 (16.9%) carried pathogenic/likely pathogenic variants. Post‐test management varied substantially across gene groups, while variant reclassification identified 46 additional carriers, underscoring the need for gene‐specific management and structured recontact.
Min‐Chae Kang, Ha‐Eun Lee, Sang‐Yoon Park, Seeyoun Lee, So‐Youn Jung, Myong Cheol Lim, Han‐Sung Kang, Chang Ahn Seol, Jun‐Ha Jang, Sang Myung Woo, Jae Young Joung, Wonyoung Choi, Sung Chan Park, Sun‐Young Kong   +13 more
wiley   +1 more source

Precision immuno-oncology in triple-negative breast cancer: from PD-L1 to multimodal biomarkers, ADC-ICI combinations, and global real-world integration. [PDF]

Front Immunol
Wu J.
europepmc   +1 more source

Update on Menopause Hormone Therapy; Current Indications and Unanswered Questions

Clinical Endocrinology, EarlyView.
ABSTRACT Objective To provide clinicians involved in managing menopause with a summary of current evidence surrounding menopause hormone therapy (MHT). Design The authors evaluate and synthesize existing pooled evidence relating to MHT's clinical indications, efficacy, and safety and explore the limitations of existing data. Patients The review focuses
Annice Mukherjee, Susan R. Davis
wiley   +1 more source

Molecular insights into triazole-based compounds for triple-negative breast cancer treatment. [PDF]

J Enzyme Inhib Med Chem
Vilangalil A, E S SP, Bukke SPN, V S, Meha N, Thalluri C, Daniel K, Ahikiriza AA.   +7 more
europepmc   +1 more source

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Large Language Model Framework for Structured Biomarker Extraction and Triple-Negative Breast Cancer Identification From Pathology Reports: Development and Evaluation Study. [PDF]

JMIR Form Res
Jain N, Annambhotla T, Siddharthan A, Kanala H, Budhiraja A, Goutam Sinha M, Charan D, Ahmad Dar M, Patel T, C L B.   +9 more
europepmc   +1 more source