Results 181 to 190 of about 82,941 (302)

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Triple-Negative Breast Cancer: Molecular Subtypes; Immune Escape; Limitations of Current Immunotherapy; and the BTLA/HVEM/CD160 Axis as an Emerging Target. [PDF]

Curr Issues Mol Biol
Rapoport BL, Anderson R, van Tonder D, Smit T, Rossouw TM, Benn CA, Steel HC.   +6 more
europepmc   +1 more source

Calcification and tumour‐infiltrating lymphocytes predict upgrade of human epidermal growth factor 2 (HER2)‐negative ductal carcinoma in situ diagnosed on core needle biopsy

Histopathology, Volume 89, Issue 1, Page 122-135, July 2026.
With evolving paradigm in treatment of patient diagnosed with pure ductal carcinoma in situ (DCIS), it is essential to stratify patients at low risk for upgrade to invasive disease at subsequent excision to inform management decisions. When combined with adequate sampling and intrinsic tumour characteristics, tumour microenvironment (TME) features ...
Monalyn Marabi, Yuyang Li, Chaiwat Aphivatanasiri, Julia Y Tsang, Joshua JX Li, Lin‐Ying Chen, Gary M Tse   +6 more
wiley   +1 more source

Regularization Approaches for High‐Dimensional Cox Models: A Case Study in Triple‐Negative Breast Cancer

International Statistical Review, EarlyView.
Summary In high‐dimensional survival analysis, effective variable selection is crucial both for model interpretation and predictive performance. This paper investigates Cox regression with lasso and adaptive lasso penalties in genomic datasets where covariates far outnumber observations.
Pilar González‐Barquero, Rosa E. Lillo, Álvaro Méndez‐Civieta   +2 more
wiley   +1 more source

TNBC

KILIÇ ERCİYAS, Seda, TUNCER, SEREF BUGRA   +1 more
openaire   +2 more sources

Advancing collagen‐related pathology assessment through second‐harmonic generation imaging

Journal of Microscopy, EarlyView.
Abstract Collagen remodelling and dysregulation are the hallmarks of diverse pathological conditions. In this context, second‐harmonic generation (SHG) imaging has emerged as a powerful label‐free modality for assessing collagen. This offers submicron resolution, intrinsic optical sectioning, and deeper imaging capabilities without the need for ...
Jackson Rodrigues, Manikanth Karnati, Gagan Raju, Edwin Pious, Ankur Gogoi, Guan‐Yu Zhuo, Nirmal Mazumder, Fu‐Jen Kao   +7 more
wiley   +1 more source

Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Prognostic Significance, Predictive Value, and Emerging Directions for Clinical Implementation. [PDF]

Cancers (Basel)
Eiamprapaporn P, Venegas Mata C, Nandani R, Susiriwatananont T, Knutson KL, Chumsri S.   +5 more
europepmc   +1 more source

Life Course Trajectories of Body Mass Index and Risk of Cancer in Adulthood: Systematic Review and Meta‐Analysis

Obesity Reviews, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to identify common life‐course body mass index (BMI) trajectories (childhood/adulthood to adulthood) and their impact on risk of cancer overall and cancer at different sites in adulthood. Methods Observational studies were identified that assessed the association of BMI trajectories with
Samira Behboudi‐Gandevani, Tommy Haugan, Nayla Cristina Do Vale Moreira, Ellen Christin Arntzen, Moira Strand Hutchinson, Melanie Nichols, Razieh Bidhendi‐Yarandi   +6 more
wiley   +1 more source

Single-cell RNA sequencing reveals immune microenvironment heterogeneity in BRCA1-mutated and sporadic triple-negative breast cancer. [PDF]

Transl Oncol
Sun Q, Zhong Y, Sun C.
europepmc   +1 more source

An Update on Early‐Onset Breast Cancer: Incidence, Risk Factors, Genetic Testing, and Treatment

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Early‐onset breast cancer presents in patients typically under the age of 40, while very early‐onset breast cancer is usually viewed as breast cancer occurring before the age of 35. Early‐onset breast cancer demonstrates specific molecular properties and has worse outcomes compared to its late‐onset breast cancer counterpart.
Leila Jahangiri
wiley   +1 more source