Results 201 to 210 of about 74,225 (263)

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Recurrence detection in patients with triple-negative breast cancer following the current standard of care: a microsimulation model. [PDF]

BMJ Open
Samur S, Hoban O, Gu NY, Carter GC, Palomares M, Arrick B, Gursel E, Yildiz Y, Ayer T, Chhatwal J, Parsons HA.   +10 more
europepmc   +1 more source

Immunomodulatory Peptide LW‐9 Enhances Doxorubicin Efficacy by Downregulating PD‐L1 and Promoting Intratumoral T‐Cell Responses in Murine Breast Cancer

Immunology, EarlyView.
LW‐9, a peptide derived from Phoneutria nigriventer venom, enhances antitumor immunity in a murine breast cancer model by remodelling the tumour microenvironment. Treatment reduces PD‐L1 expression while increasing CD3+ and GITR+ T‐cell infiltration, resulting in delayed tumour progression, particularly when combined with doxorubicin.
Ingrid Mayara Cavalcante Trevisan, Cibele Pereira Mariano, Sabrina Carvalho Brunelli, Gabriel da Silva Cordeiro, Jessika Takaki, Valquiria Aparecida Matheus, Liana Verinaud, Catarina Rapôso   +7 more
wiley   +1 more source

Regularization Approaches for High‐Dimensional Cox Models: A Case Study in Triple‐Negative Breast Cancer

International Statistical Review, EarlyView.
Summary In high‐dimensional survival analysis, effective variable selection is crucial both for model interpretation and predictive performance. This paper investigates Cox regression with lasso and adaptive lasso penalties in genomic datasets where covariates far outnumber observations.
Pilar González‐Barquero, Rosa E. Lillo, Álvaro Méndez‐Civieta   +2 more
wiley   +1 more source

Advancing collagen‐related pathology assessment through second‐harmonic generation imaging

Journal of Microscopy, EarlyView.
Abstract Collagen remodelling and dysregulation are the hallmarks of diverse pathological conditions. In this context, second‐harmonic generation (SHG) imaging has emerged as a powerful label‐free modality for assessing collagen. This offers submicron resolution, intrinsic optical sectioning, and deeper imaging capabilities without the need for ...
Jackson Rodrigues, Manikanth Karnati, Gagan Raju, Edwin Pious, Ankur Gogoi, Guan‐Yu Zhuo, Nirmal Mazumder, Fu‐Jen Kao   +7 more
wiley   +1 more source

Identifying barriers to immunotherapy access for triple-negative breast cancer: A qualitative analysis of interviews with medical oncologists. [PDF]

PLoS One
Jutagir DR, Espinosa A, Lopez M, Claros M, Gomez T, Gilliland J, Traina TA, Petersen B, Gany F.   +8 more
europepmc   +1 more source

An Update on Early‐Onset Breast Cancer: Incidence, Risk Factors, Genetic Testing, and Treatment

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Early‐onset breast cancer presents in patients typically under the age of 40, while very early‐onset breast cancer is usually viewed as breast cancer occurring before the age of 35. Early‐onset breast cancer demonstrates specific molecular properties and has worse outcomes compared to its late‐onset breast cancer counterpart.
Leila Jahangiri
wiley   +1 more source

A real-world nomogram integrating predictive markers for disease-free survival in postmenopausal triple-negative breast cancer receiving anthracycline/taxane-based chemotherapy. [PDF]

Front Oncol
Lin Y, Yu SH, Zeng CM, Cai SL, Han L.
europepmc   +1 more source

The Evolution of Breast Cancer Detection: A Review of Imaging, Machine Learning, and Multimodal Strategies

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Breast cancer is still a serious problem in the world arena, where its early and prompt detection is the most important factor in improving patient prognosis and survival. The use of traditional diagnostic techniques, such as imaging (e.g., mammography and ultrasound) and subsequent histopathological examination, is the mainstay, which ...
Likhon Chandra Sarkar, Farida Siddiqi Prity, Farhad Hussain, Anup Talukder, Mirza Raquib, Sharmina Rahman, MD Jiabul Hoque   +6 more
wiley   +1 more source