Assessment of Anti-TNF-α Activities in Keratinocytes Expressing Inducible TNF- α: A Novel Tool for Anti-TNF-α Drug Screening. [PDF]
PLoS ONE, 2016 Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine important in normal and pathological biological processes. Newly synthesized pro-TNF-α is expressed on the plasma membrane and cleaved to release soluble TNF-α protein: both are ...
Sutthirat Udommethaporn +3 more
doaj +4 more sources
TNF-α Differentially Regulates Cell Cycle Genes in Promyelocytic and Granulocytic HL-60/S4 Cells [PDF]
G3: Genes, Genomes, Genetics, 2019 Tumor necrosis factor alpha (TNF-α) is a potent cytokine involved in systemic inflammation and immune modulation. Signaling responses that involve TNF-α are context dependent and capable of stimulating pathways promoting both cell death and survival. TNF-
Elsie C. Jacobson +6 more
doaj +3 more sources
The inflammatory cytokine tumor necrosis factor modulates the expression of
Journal of Inflammation, 2010 Tumor necrosis factor α (TNF-α)is a host inflammatory factor. Bacteria increase TNF-α expression in a variety of human diseases including infectious diseases, inflammatory bowel diseases, and cancer.
Ma Jun +3 more
doaj +3 more sources
Mechanism of inhibitory effect of atorvastatin on resistin expression induced by tumor necrosis factor-α in macrophages [PDF]
Journal of Biomedical Science, 2009 Atorvastatin has been shown to reduce resistin expression in macrophages after pro-inflammatory stimulation. However, the mechanism of reducing resistin expression by atorvastatin is not known. Therefore, we sought to investigate the molecular mechanisms
Chua Su-Kiat +3 more
doaj +5 more sources
Exhaled Volatile Organic Compounds during Inflammation Induced by TNF-α in Ventilated Rats [PDF]
Metabolites, 2020 Systemic inflammation alters the composition of exhaled breath, possibly helping clinicians diagnose conditions such as sepsis. We therefore evaluated changes in exhaled breath of rats given tumor necrosis factor-alpha (TNF-α). Thirty male Sprague-Dawley
Frederic W. Albrecht +9 more
doaj +3 more sources
Akt regulates IL-10 mediated suppression of TNFα-induced cardiomyocyte apoptosis by upregulating Stat3 phosphorylation. [PDF]
PLoS ONE, 2011 We have already reported that TNF-α increases cardiomyocyte apoptosis and IL-10 treatment prevented these effects of TNF-α. Present study investigates the role of Akt and Jak/Stat pathway in the IL-10 modulation of TNF-α induced cardiomyocyte apoptosis ...
Sanjiv Dhingra +4 more
doaj +5 more sources
Assessment of IL6 and TNF α in Chronic Lymphocytic Leukemia [PDF]
International Journal of Medical Arts, 2022 Background: Among the cytokines and inflammatory markers, Interleukin 6 [IL6] and TNF α are the most common markers in the practice of medicine. Many studies determine the values of these two markers among the patients with chronic lymphocytic leukemia ...
Mohamed Abd-El-Haleem Mousa +3 more
doaj +1 more source
IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells. [PDF]
, 2012 Connective tissue growth factor (CTGF/CCN2) is an angiogenetic and profibrotic factor, acting downstream of TGF-β, involved in both airway- and vascular remodeling.
Fehrholz, Markus +6 more
core +11 more sources
Tristetraprolin Down-Regulation Contributes to Persistent TNF-Alpha Expression Induced by Cigarette Smoke Extract through a Post-Transcriptional Mechanism. [PDF]
PLoS ONE, 2016 Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD).
Xue-Ke Zhao +20 more
doaj +1 more source
Inflammatory markers and bone mass in children with overweight/obesity: the role of muscular fitness [PDF]
, 2020 Objectives To examine which inflammatory markers are associated with bone mass and whether this association varies according to muscular fitness in children with overweight/obesity.
Adelantado-Renau, Mireia +12 more
core +1 more source