Results 91 to 100 of about 565,658 (299)

Quantitative comparison of the neutralizing capacity, immunogenicity and cross-reactivity of anti-TNF-α biologicals and an Infliximab-biosimilar.

PLoS ONE, 2018
IntroductionTNF-α-neutralizing antibodies, such as infliximab (IFX) and adalimumab (ADA), are effective in the treatment of inflammatory bowel diseases (IBD), but they are expensive and become ineffective when patients develop anti-IFX or anti-ADA ...
D J Buurman, T Blokzijl, E A M Festen, B T Pham, K N Faber, E Brouwer, G Dijkstra   +6 more
doaj   +1 more source

Vaginal Chlamydial Clearance Following Primary or Secondary Infection in Mice Occurs Independently of TNF-α

Frontiers in Cellular and Infection Microbiology, 2013
The role of TNF-α in chlamydial clearance is uncertain. Antibody-mediated depletion of TNF-α in mice and guinea pigs has been shown not to significantly affect chlamydial clearance, whereas production of TNF-α in addition to IFN-γ from T cells has been ...
Sangamithra eKamalakaran, Bharat eChaganty, Rishein eGupta, Rishein eGupta, M. Neal Guentzel, M. Neal Guentzel, James Patrick Chambers, James Patrick Chambers, Ashlesh eMurthy, Bernard eArulanandam, Bernard eArulanandam   +10 more
doaj   +1 more source

Hubungan kadar TNF-α dengan HOMA-IR pada pasien diabetes mellitus tipe-2 di Rumah Sakit Umum Pusat Haji Adam Malik, Medan, Indonesia

Intisari Sains Medis, 2019
Background: The homeostatic assessment (HOMA) of the first cell-β (B) and insulin (IR) function is used to determine insulin sensitivity and cell-β function of insulin plasma concentrations and fasting glucose. High extracellular glucose levels will trigger an increase in ROS production (which in turn will increase the formation of Reactive Oxygen ...
Poltak Poltak, Santi Syafril, Ratna Akbari Ganie   +2 more
openaire   +2 more sources

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

The effect of duration of wound skin tissue on MDA, TNF-α, IL-6, Caspase 3, VEGF levels, and granulation tissue thickness in the white rat (Rattus novergicus)

Bali Medical Journal, 2020
Introduction: Wound is the result of physical trauma that severs skin continuities. The damage typically causes an inflammatory reaction marked by increase ROS and tissue inflammation. However, this process is still needed to be further investigated. Therefore, this study aimed to evaluate plasma MDA, IL-6, TNF-α, Caspase-3 and VEGF levels, and the ...
Amru Sungkar, Danar Widyatmoko, Kristanto Yuli Yarso, Brian Wasita   +3 more
openaire   +1 more source

Self‐Immolative Activatable Nanoassembly toward Immuno‐Photodynamic Therapy in TME

Advanced Functional Materials, EarlyView.
A quinone methide‐gated, self‐immolative, H2O2‐responsive nano‐photosensitizer (Pyz/PS) is developed for targeted immuno‐photodynamic therapy. Pyz/PS selectively activates within tumor microenvironments, restores photosensitizer activity, generates ROS, and depletes intracellular GSH, enhancing oxidative stress.
Jing Li, E Pang, Snehasish Debnath, Jia Hong, Aojun Qiu, Dongeun Kim, Goeun Kim, Minhuan Lan, Min‐Goo Lee, Qian‐Yong Cao, Jong Seung Kim   +10 more
wiley   +1 more source

Circulating TNF-α levels in rheumatoid arthritis: a systematic review and meta-analysis and comparison to TNF-α levels in sepsis

Therapeutic Advances in Infectious Disease
Background: Tumor necrosis factor-alpha (TNF-α) is implicated in the pathogenesis of autoimmune conditions and sepsis. Although anti-TNF-α therapies have demonstrated clinical efficacy in rheumatoid arthritis (RA), there is no established evidence for ...
Sias Scherger, Andrés F. Henao-Martinez, Carlos Franco-Paredes, Binh T. Ngo, Alyssa Grimshaw, Ranjit Sah, Sangam Shah, Stefan Sillau, Alfonso G. Bastias, Michaele Francesco Corbisiero, Hannah M. Kyllo, Jordan Stellern, Leland Shapiro   +12 more
doaj   +1 more source

Pengaruh Pemberian Daun Ubi Jalar Ungu (Ipomoea batatas Lam) terhadap Kadar TNF-Α, Il-6 dan Nf-Κb pada Tikus yang Dipapar Asap Rokok

Jurnal Kedokteran Brawijaya, 2015
Peningkatan stres oksidatif dapat memicu inflamasi yang berperan dalam perkembangan Chronic Obstructive Pulmonary Disease (COPD). Daun ubijalarungu/Purple Sweet Potato Leaves (PSPL) memiliki kandungan polifenol yang tinggi yaitu sebesar 1805mg GEA (gallic acid eguivalent) dalam 100 gram tepung PSPL.
Inggita Kusumastuty, Prasetyo Adi, Leny Budhi Harti, Fajar Ari Nugroho   +3 more
openaire   +2 more sources

Association between Elevated TNF-α Levels and Severe Malaria

Galen Medical Journal, 2023
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openaire   +2 more sources

Light‐Responsive Enzyme‐Loaded Nanoparticles for Tunable Adhesion and Mechanical Wound Contraction

Advanced Functional Materials, EarlyView.
This study presents a photoactivatable enzyme‐loaded mesoporous nanoparticle system (MPDA_PaTy) that enables light‐triggered tunable tissue adhesion and facilitates mechanical wound contraction. Controlled enzymatic crosslinking at tissue or hydrogel interfaces allows on‐demand adhesion.
Junghyeon Ko, Hyeon‐Jin Kim, Jeong‐Uk Kim, Seh Ri Oh, Tae Hoon Kang, Junghwan Byun, Uk‐Jae Lee, Minglin Ma, Su‐Hwan Kim, Byung‐Gee Kim, Nathaniel S. Hwang   +10 more
wiley   +1 more source